Aliases for RGS1 Gene
External Ids for RGS1 Gene
Previous HGNC Symbols for RGS1 Gene
Previous GeneCards Identifiers for RGS1 Gene
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS1 Gene
RGS1 (Regulator Of G Protein Signaling 1) is a Protein Coding gene. Diseases associated with RGS1 include Hemorrhoid and Griscelli Syndrome, Type 3. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS3.
UniProtKB/Swiss-Prot Summary for RGS1 Gene
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).