Aliases for RGS1 Gene
External Ids for RGS1 Gene
Previous HGNC Symbols for RGS1 Gene
Previous GeneCards Identifiers for RGS1 Gene
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS1 Gene
RGS1 (Regulator Of G Protein Signaling 1) is a Protein Coding gene. Diseases associated with RGS1 include Griscelli Syndrome, Type 3 and Vertical Talus, Congenital. Among its related pathways are G-AlphaQ Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS3.
UniProtKB/Swiss-Prot Summary for RGS1 Gene
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).