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Aliases for RGPD1 Gene

Aliases for RGPD1 Gene

  • RANBP2-Like And GRIP Domain Containing 1 2 3 5
  • Ran-Binding Protein 2-Like 6 3 4
  • RanBP2-Like 6 3 4
  • RanBP2L6 3 4
  • RGP1 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 1/2 3
  • RANBP2-Like And GRIP Domain-Containing Protein 1 3
  • Ran-Binding Protein 2-Like 2/6 3
  • RanBP2-Like 2/6 3
  • RanBP2L2 3
  • RGPD2 3

External Ids for RGPD1 Gene

Previous GeneCards Identifiers for RGPD1 Gene

  • GC02P087013
  • GC02U900966
  • GC02P086994
  • GC02P087135

Summaries for RGPD1 Gene

GeneCards Summary for RGPD1 Gene

RGPD1 (RANBP2-Like And GRIP Domain Containing 1) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is RGPD2.

Additional gene information for RGPD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD1 Gene

Genomics for RGPD1 Gene

GeneHancer (GH) Regulatory Elements for RGPD1 Gene

Promoters and enhancers for RGPD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I086254 Enhancer 0.5 ENCODE dbSUPER 4.6 -652.6 -652607 1.3 RFX1 MRPL35 REEP1 RGPD1 GC02M086172 GC02M086283
GH02I086053 Enhancer 0.2 dbSUPER 4 -852.5 -852543 4.4 POLR1A MRPL35 LOC284950 RNU1-38P RGPD1 GC02M086068 GC02M086022
GH02I086913 Promoter 0.5 Ensembl 0.4 +6.1 6148 0.6 ENSG00000231259 CD8B PLGLB1 RGPD1 GC02M086930 GC02M086893
GH02I086930 Promoter 0.5 Ensembl 0.3 +22.8 22848 0.4 GC02M086930 LOC100420109 LOC730268 RGPD1 GC02M086893
GH02I086941 Enhancer 0.2 Ensembl 0.3 +35.0 35001 2.1 ENSG00000231259 PLGLB1 MRPL35 PIR57142 NDUFB4P5 RGPD1 GC02M086893
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGPD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGPD1 gene promoter:

Genomic Locations for RGPD1 Gene

Genomic Locations for RGPD1 Gene
106,024 bases
Plus strand

Genomic View for RGPD1 Gene

Genes around RGPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD1 Gene

Proteins for RGPD1 Gene

  • Protein details for RGPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • P0C839
    • Q68DN6
    • Q6V1X0

    Protein attributes for RGPD1 Gene

    1748 amino acids
    Molecular mass:
    196662 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

neXtProt entry for RGPD1 Gene

Post-translational modifications for RGPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGPD1 Gene

Domains & Families for RGPD1 Gene

Gene Families for RGPD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGPD1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RGPD1 Gene

Function for RGPD1 Gene

Phenotypes From GWAS Catalog for RGPD1 Gene

Phenotypes for RGPD1 Gene

genes like me logo Genes that share phenotypes with RGPD1: view

Animal Model Products

CRISPR Products

miRNA for RGPD1 Gene

miRTarBase miRNAs that target RGPD1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD1 Gene

Localization for RGPD1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGPD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RGPD1 Gene

Pathways & Interactions for RGPD1 Gene

SuperPathways for RGPD1 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD1: view

Pathways by source for RGPD1 Gene

1 KEGG pathway for RGPD1 Gene

Gene Ontology (GO) - Biological Process for RGPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046907 intracellular transport IEA --
genes like me logo Genes that share ontologies with RGPD1: view

No data available for SIGNOR curated interactions for RGPD1 Gene

Drugs & Compounds for RGPD1 Gene

No Compound Related Data Available

Transcripts for RGPD1 Gene

mRNA/cDNA for RGPD1 Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD1 Gene

RANBP2-like and GRIP domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD1 Gene

No ASD Table

Relevant External Links for RGPD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGPD1 Gene

mRNA differential expression in normal tissues according to GTEx for RGPD1 Gene

This gene is overexpressed in Testis (x16.4), Cervix - Endocervix (x13.6), and Pituitary (x5.5).

Protein differential expression in normal tissues from HIPED for RGPD1 Gene

This gene is overexpressed in Nasal epithelium (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGPD1 Gene

Protein tissue co-expression partners for RGPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGPD1 Gene:


SOURCE GeneReport for Unigene cluster for RGPD1 Gene:

genes like me logo Genes that share expression patterns with RGPD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGPD1 Gene

Orthologs for RGPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
(Mus musculus)
Mammalia Ranbp2 33
  • 87.81 (n)
(Bos Taurus)
Mammalia RANBP2 33
  • 85.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
-- 34
  • 75 (a)
(Gallus gallus)
Aves RANBP2 33
  • 71.13 (n)
-- 34
  • 58 (a)
-- 34
  • 48 (a)
-- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 33
  • 66.51 (n)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 33
  • 56.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y17G9B.4 34
  • 13 (a)
T22F3.12 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 4 (a)
Species where no ortholog for RGPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD1 Gene

Gene Tree for RGPD1 (if available)
Gene Tree for RGPD1 (if available)

Paralogs for RGPD1 Gene

(8) SIMAP similar genes for RGPD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD1: view

Variants for RGPD1 Gene

Sequence variations from dbSNP and Humsavar for RGPD1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000031346 -- 86,929,788(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000092262 -- 86,940,166(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000145615 -- 86,918,781(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000146035 -- 86,940,640(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000228908 -- 86,944,183(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD1 Gene

Variant ID Type Subtype PubMed ID
dgv1141e212 CNV loss 25503493
dgv3886n100 CNV gain 25217958
dgv3887n100 CNV gain 25217958
dgv3889n100 CNV loss 25217958
dgv3893n100 CNV gain 25217958
dgv3901n100 CNV gain+loss 25217958
dgv3908n100 CNV gain 25217958
dgv61n16 CNV deletion 17901297
dgv6947n54 CNV gain 21841781
dgv714e214 CNV gain 21293372
esv1743470 CNV deletion 17803354
esv25494 CNV gain 19812545
esv27348 CNV gain 19812545
esv2759073 CNV gain+loss 17122850
esv2763649 CNV gain+loss 21179565
esv33176 CNV loss 17666407
esv3559780 CNV deletion 23714750
esv3892915 CNV gain 25118596
nsv10064 CNV gain 18304495
nsv10070 CNV gain 18304495
nsv10071 CNV gain 18304495
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1141341 CNV duplication 24896259
nsv1148611 CNV deletion 26484159
nsv2815 CNV deletion 18451855
nsv498927 CNV loss 21111241
nsv508849 CNV insertion 20534489
nsv516958 CNV gain+loss 19592680
nsv519198 CNV loss 19592680
nsv582382 CNV gain 21841781
nsv582383 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv820913 CNV deletion 20802225
nsv829493 CNV gain 20364138
nsv829494 CNV gain 20364138
nsv834287 CNV gain 17160897
nsv834288 CNV gain 17160897
nsv955219 CNV duplication 24416366
nsv955226 CNV duplication 24416366
nsv956666 CNV deletion 24416366
nsv961581 CNV duplication 23825009
nsv961808 CNV duplication 23825009
nsv961809 CNV duplication 23825009
nsv961810 CNV duplication 23825009
nsv963632 CNV duplication 23825009
nsv963633 CNV duplication 23825009
nsv979033 CNV duplication 23825009
nsv979034 CNV duplication 23825009
nsv979040 CNV duplication 23825009

Variation tolerance for RGPD1 Gene

Gene Damage Index Score: 1.84; 34.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD1 Gene

Disorders for RGPD1 Gene

Additional Disease Information for RGPD1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD1 Gene

Publications for RGPD1 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli FD … Bork P (Genome research 2005) 2 3 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for RGPD1 Gene

Sources for RGPD1 Gene

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