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Aliases for RGN Gene

Aliases for RGN Gene

  • Regucalcin 2 3 3 5
  • Gluconolactonase 2 3 4
  • Senescence Marker Protein 30 3 4
  • SMP30 3 4
  • GNL 3 4
  • RC 3 4
  • Regucalcin (Senescence Marker Protein-30) 2
  • Epididymis Secretory Protein Li 41 3
  • Senescence Marker Protein-30 2
  • EC 4
  • HEL-S-41 3
  • SMP-30 4

External Ids for RGN Gene

Previous GeneCards Identifiers for RGN Gene

  • GC0XP045740
  • GC0XP045198
  • GC0XP045983
  • GC0XP046695
  • GC0XP046822
  • GC0XP046937
  • GC0XP044651

Summaries for RGN Gene

Entrez Gene Summary for RGN Gene

  • The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for RGN Gene

RGN (Regucalcin) is a Protein Coding gene. Diseases associated with RGN include Aging. Among its related pathways are Pentose phosphate pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and gluconolactonase activity.

UniProtKB/Swiss-Prot for RGN Gene

  • Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

Gene Wiki entry for RGN Gene

Additional gene information for RGN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGN Gene

Genomics for RGN Gene

GeneHancer (GH) Regulatory Elements for RGN Gene

Promoters and enhancers for RGN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ047077 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 664.2 +1.5 1526 4.7 FOXA2 MLX ARID4B SIN3A ZNF48 YY1 RXRA SP5 NFYC REST RGN CHST7 GC0XP047088
GH0XJ047143 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 35.6 +66.9 66947 3.8 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 FOS NDUFB11 RBM10 RGN INE1 UBA1 ZNF81 ARAF
GH0XJ047297 Enhancer 0.6 ENCODE 26.3 +219.5 219545 1 SMARCE1 NEUROD1 DPF2 CEBPG E4F1 ZNF217 CTBP1 CREB1 FOS ENSG00000203402 RGN SNORA11C LOC100419232 PIR34305
GH0XJ047321 Enhancer 0.9 FANTOM5 ENCODE 8 +243.5 243514 1.7 ATF1 YY2 NRF1 SIX5 YY1 ETS1 POLR2A ZNF143 NR2C1 RUNX3 SNORA11C LOC100419232 RGN UBA1 CDK16 ELK1 PIR34305 GC0XM047351
GH0XJ047315 Enhancer 0.6 ENCODE 5.7 +238.4 238361 2.2 SCRT1 MXI1 RFX1 NANOG MAX BMI1 SP1 POLR2A RFX3 PIR34305 INE1 UBA1 SNORA11C LOC100419232 RGN ENSG00000203402
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGN gene promoter:
  • NRSF form 2
  • NRSF form 1
  • AREB6
  • FOXO1
  • FOXO1a
  • GR-alpha
  • FOXD3
  • HSF2

Genomic Locations for RGN Gene

Genomic Locations for RGN Gene
14,960 bases
Plus strand
14,938 bases
Plus strand

Genomic View for RGN Gene

Genes around RGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGN Gene

Proteins for RGN Gene

  • Protein details for RGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A4FTW1
    • A8K271
    • Q53FC9
    • Q5JRR5

    Protein attributes for RGN Gene

    299 amino acids
    Molecular mass:
    33253 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for RGN Gene

    Alternative splice isoforms for RGN Gene


neXtProt entry for RGN Gene

Post-translational modifications for RGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGN Gene

Domains & Families for RGN Gene

Gene Families for RGN Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMP-30/CGR1 family.
  • Belongs to the SMP-30/CGR1 family.
genes like me logo Genes that share domains with RGN: view

Function for RGN Gene

Molecular function for RGN Gene

UniProtKB/Swiss-Prot Function:
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
D-glucono-1,5-lactone + H(2)O = D-gluconate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.7 mM for gluconolactone (with Zn(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=0.6 mM for gluconolactone (with Mn(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=1.3 mM for gluconolactone (with Mg(2+) as cofactor) {ECO:0000269 PubMed:20329768}; KM=3.7 mM for gluconolactone (with Ca(2+) as cofactor) {ECO:0000269 PubMed:20329768};
GENATLAS Biochemistry:
rat calcium binding protein (regucalcin) homolog

Enzyme Numbers (IUBMB) for RGN Gene

Gene Ontology (GO) - Molecular Function for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004341 gluconolactonase activity IDA,IEA 20329768
GO:0005509 calcium ion binding ISS,TAS --
GO:0008270 zinc ion binding IDA 20329768
GO:0016787 hydrolase activity IEA --
GO:0030234 enzyme regulator activity IEA --
genes like me logo Genes that share ontologies with RGN: view
genes like me logo Genes that share phenotypes with RGN: view

Animal Models for RGN Gene

MGI Knock Outs for RGN:
  • Rgn Rgn<tm1Aish>

Animal Model Products

miRNA for RGN Gene

miRTarBase miRNAs that target RGN

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGN Gene

Localization for RGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGN Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGN gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RGN: view

Pathways & Interactions for RGN Gene

genes like me logo Genes that share pathways with RGN: view

Pathways by source for RGN Gene

Gene Ontology (GO) - Biological Process for RGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001889 liver development IEA --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006874 cellular calcium ion homeostasis ISS --
genes like me logo Genes that share ontologies with RGN: view

No data available for SIGNOR curated interactions for RGN Gene

Drugs & Compounds for RGN Gene

(7) Drugs for RGN Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
Gluconic acid Approved Pharma 0
Gluconolactone Approved, Experimental Pharma 0

(9) Additional Compounds for RGN Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Hydroxyhexanoic acid
  • 5-Carboxypentanol
  • 5-Hydroxypentanecarboxylic acid
  • 6-Hydroxy caproic acid
  • 6-Hydroxycaproic acid
  • 6-Hydroxyhexanoate
  • 1,6-Hexanolide
  • 1-Oxa-2-oxocycloheptane
  • 2-Oxacycloheptanone
  • 2-Oxepanone
  • 2-Oxohexamethylene oxide
Gulonic acid
  • D-Gulonate
  • D-Gulonic acid
  • Gulonate
  • L-Gulonate
  • L-Gulonic acid
  • gamma-Gulonolactone
  • L-Gulonic acid gamma-lactone
  • L-gulono-gamma-Lactone
  • g-Gulonolactone
  • γ-gulonolactone
genes like me logo Genes that share compounds with RGN: view

Transcripts for RGN Gene

Unigene Clusters for RGN Gene

Regucalcin (senescence marker protein-30):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: -
SP3: - - - - -

Relevant External Links for RGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGN Gene

This gene is overexpressed in Adrenal Gland (x10.0) and Liver (x8.9).

Protein differential expression in normal tissues from HIPED for RGN Gene

This gene is overexpressed in Liver, secretome (27.1) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGN Gene

Protein tissue co-expression partners for RGN Gene

NURSA nuclear receptor signaling pathways regulating expression of RGN Gene:


SOURCE GeneReport for Unigene cluster for RGN Gene:


Evidence on tissue expression from TISSUES for RGN Gene

  • Liver(4.8)
  • Nervous system(4.5)
  • Intestine(4.3)
  • Adrenal gland(2.9)
  • Kidney(2.9)
genes like me logo Genes that share expression patterns with RGN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGN Gene

Orthologs for RGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RGN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGN 34 33
  • 91.19 (n)
(Canis familiaris)
Mammalia RGN 34 33
  • 89.63 (n)
(Pan troglodytes)
Mammalia RGN 34 33
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Rgn 33
  • 86.85 (n)
(Mus musculus)
Mammalia Rgn 16 34 33
  • 86.51 (n)
(Monodelphis domestica)
Mammalia RGN 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia RGN 34
  • 60 (a)
(Gallus gallus)
Aves RGN 34 33
  • 73.47 (n)
(Anolis carolinensis)
Reptilia RGN 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgn 33
  • 69.23 (n)
Str.11947 33
African clawed frog
(Xenopus laevis)
Amphibia rgn-A 33
(Danio rerio)
Actinopterygii rgn 34 33
  • 65.08 (n)
Dr.27166 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9879 33
fruit fly
(Drosophila melanogaster)
Insecta regucalcin 34 35 33
  • 48.68 (n)
smp-30 34
  • 33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04301g 33
  • 41.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBR053C 33
  • 40.95 (n)
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL098W 33
  • 39.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00326 33
  • 44.24 (n)
Species where no ortholog for RGN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGN Gene

Gene Tree for RGN (if available)
Gene Tree for RGN (if available)
Evolutionary constrained regions (ECRs) for RGN: view image

Paralogs for RGN Gene

No data available for Paralogs for RGN Gene

Variants for RGN Gene

Sequence variations from dbSNP and Humsavar for RGN Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000470853 -- 47,077,694(+) G/A upstream_transcript_variant
rs1000606111 -- 47,078,119(+) G/A upstream_transcript_variant
rs1000794627 -- 47,085,523(+) A/T intron_variant
rs1001101222 -- 47,085,285(+) C/T intron_variant
rs1001529586 -- 47,079,923(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGN Gene

Variant ID Type Subtype PubMed ID
esv1734378 CNV insertion 17803354
esv3448339 CNV duplication 20981092
nsv1132239 CNV deletion 24896259
nsv508767 CNV insertion 20534489
nsv513604 CNV insertion 21212237

Variation tolerance for RGN Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGN Gene

Disorders for RGN Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGN Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search RGN in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGN Gene

Publications for RGN Gene

  1. Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. (PMID: 7548213) Fujita T … Maruyama N (Biochimica et biophysica acta 1995) 2 3 4 22 58
  2. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . (PMID: 20329768) Chakraborti S … Bahnson BJ (Biochemistry 2010) 3 4 22 58
  3. Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin. (PMID: 10677570) Misawa H … Yamaguchi M (International journal of molecular medicine 2000) 3 4 22 58
  4. Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase. (PMID: 23349732) Aizawa S … Senda T (PloS one 2013) 3 4 58
  5. A strategy for the production of soluble human senescence marker protein-30 in Escherichia coli. (PMID: 20152811) Choi MS … Chilukuri N (Biochemical and biophysical research communications 2010) 3 22 58

Products for RGN Gene

Sources for RGN Gene

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