Aliases for RGN Gene
External Ids for RGN Gene
Previous GeneCards Identifiers for RGN Gene
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for RGN Gene
RGN (Regucalcin) is a Protein Coding gene. Diseases associated with RGN include Aging and Hypoascorbemia. Among its related pathways are Carbon metabolism and Pentose and glucuronate interconversions. Gene Ontology (GO) annotations related to this gene include calcium ion binding and gluconolactonase activity.
UniProtKB/Swiss-Prot Summary for RGN Gene
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).