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This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
RGMA (Repulsive Guidance Molecule BMP Co-Receptor A) is a Protein Coding gene. Diseases associated with RGMA include Amusia and Hemochromatosis Type 2. Among its related pathways are Signaling by BMP and Axon guidance. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is RGMB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0015026 | coreceptor activity | IBA | 21873635 |
GO:1990459 | transferrin receptor binding | IPI | 22728873 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IDA | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology |
.51
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|
2 | Axon guidance | ||
3 | TGF-beta signaling pathway (KEGG) | ||
4 | Netrin-1 signaling | ||
5 | Signaling by BMP |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001843 | neural tube closure | IEA | -- |
GO:0010975 | regulation of neuron projection development | IEA | -- |
GO:0010976 | positive regulation of neuron projection development | IEA | -- |
GO:0010977 | negative regulation of neuron projection development | IEA | -- |
GO:0030509 | BMP signaling pathway | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||
SP8: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RGMA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RGMA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RGMA 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rgma 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rgma 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RGMA 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RGMA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RGMA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RGMA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rgma 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | rgma-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rgma 30 31 |
|
OneToOne | |
wufb36g11 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | drag-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3942115 | Benign: not provided | 93,073,717(-) |
A/G NM_001166283.1(RGMA):c.38+2T>C |
SPLICE_DONOR_VARIANT,INTRON | |
rs61733836 | Benign: not provided | 93,045,427(-) |
G/A NM_001166283.1(RGMA):c.948C>T (p.Asp316=) |
SYNONYMOUS | |
rs4238485 | - |
p.Asp415Glu |
|||
rs4778078 | - |
p.Ala431Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
amusia |
|
|
hemochromatosis type 2 |
|
|