This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016] See more...

Aliases for RGL4 Gene

Aliases for RGL4 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 4 2 3 5
  • RalGDS Related Oncogene 2 3
  • Ral-GDS-Related Protein 3 4
  • RalGDS-Like 4 3 4
  • Rgr 2 3
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 4 4
  • Ral-GDS Related Protein Rgr 3
  • RGL4 5
  • HRGR 4
  • RGR 4

External Ids for RGL4 Gene

Previous GeneCards Identifiers for RGL4 Gene

  • GC22P022360
  • GC22P024030
  • GC22P007020

Summaries for RGL4 Gene

Entrez Gene Summary for RGL4 Gene

  • This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]

GeneCards Summary for RGL4 Gene

RGL4 (Ral Guanine Nucleotide Dissociation Stimulator Like 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000285245.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGL4 Gene

Genomics for RGL4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGL4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGL4

Top Transcription factor binding sites by QIAGEN in the RGL4 gene promoter:
  • ARP-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LyF-1
  • Roaz
  • RORalpha2

Genomic Locations for RGL4 Gene

Genomic Locations for RGL4 Gene
chr22:23,688,136-23,699,176
(GRCh38/hg38)
Size:
11,041 bases
Orientation:
Plus strand
chr22:24,030,323-24,041,363
(GRCh37/hg19)
Size:
11,041 bases
Orientation:
Plus strand

Genomic View for RGL4 Gene

Genes around RGL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL4 Gene

Proteins for RGL4 Gene

  • Protein details for RGL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ4-RGDSR_HUMAN
    Recommended name:
    Ral-GDS-related protein
    Protein Accession:
    Q8IZJ4
    Secondary Accessions:
    • Q495L8

    Protein attributes for RGL4 Gene

    Size:
    473 amino acids
    Molecular mass:
    52346 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01109.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL4 Gene

Post-translational modifications for RGL4 Gene

  • Ubiquitination at Lys417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RGL4 Gene

Domains & Families for RGL4 Gene

Gene Families for RGL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGL4 Gene

InterPro:
Blocks:
  • Guanine-nucleotide dissociation stimulator CDC25
ProtoNet:

Suggested Antigen Peptide Sequences for RGL4 Gene

GenScript: Design optimal peptide antigens:
  • RGL4 protein (Q3ZCN2_HUMAN)
  • RGL4 protein (Q495L7_HUMAN)
  • RGL4 protein (Q495L8_HUMAN)
  • Ral guanine nucleotide dissociation stimulator-like 4 (RGDSR_HUMAN)
genes like me logo Genes that share domains with RGL4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGL4 Gene

Function for RGL4 Gene

Phenotypes From GWAS Catalog for RGL4 Gene

Gene Ontology (GO) - Molecular Function for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RGL4: view
genes like me logo Genes that share phenotypes with RGL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGL4 Gene

Localization for RGL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGL4 Gene

Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL4 gene
Compartment Confidence
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with RGL4: view

Pathways & Interactions for RGL4 Gene

PathCards logo

SuperPathways for RGL4 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with RGL4: view

Pathways by source for RGL4 Gene

1 BioSystems pathway for RGL4 Gene
1 GeneTex pathway for RGL4 Gene

Gene Ontology (GO) - Biological Process for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RGL4: view

No data available for SIGNOR curated interactions for RGL4 Gene

Drugs & Compounds for RGL4 Gene

(2) Drugs for RGL4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tramadol Approved, Investigational Pharma 345
o-desmethyltramadol Pharma 0
genes like me logo Genes that share compounds with RGL4: view

Transcripts for RGL4 Gene

mRNA/cDNA for RGL4 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL4

Alternative Splicing Database (ASD) splice patterns (SP) for RGL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for RGL4 Gene

GeneLoc Exon Structure for
RGL4

Expression for RGL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL4 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for RGL4 Gene

This gene is overexpressed in Tlymphocyte (45.5), Fetal gut (14.8), and NK cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGL4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGL4

SOURCE GeneReport for Unigene cluster for RGL4 Gene:

Hs.658997
genes like me logo Genes that share expression patterns with RGL4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL4 Gene

Orthologs for RGL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGL4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGL4 30 31
  • 96.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 39 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia RGL4 31
  • 18 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 10 (a)
ManyToMany
Species where no ortholog for RGL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RGL4 Gene

ENSEMBL:
Gene Tree for RGL4 (if available)
TreeFam:
Gene Tree for RGL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGL4: view image

Paralogs for RGL4 Gene

(7) SIMAP similar genes for RGL4 Gene using alignment to 8 proteins:

  • RGDSR_HUMAN
  • B5MCW5_HUMAN
  • E7EPT8_HUMAN
  • E9PH21_HUMAN
  • H7C063_HUMAN
  • Q3ZCN2_HUMAN
  • Q495L7_HUMAN
  • Q495L8_HUMAN

Pseudogenes.org Pseudogenes for RGL4 Gene

genes like me logo Genes that share paralogs with RGL4: view

Variants for RGL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGL4 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs1007298 - p.Val378Ala
rs17003394 - p.Arg37Cys
rs17003397 - p.Thr216Met
rs17003398 - p.Glu297Lys
rs2070446 - p.His241Tyr

Additional dbSNP identifiers (rs#s) for RGL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGL4 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv2751941 CNV gain 17911159
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for RGL4 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL4 Gene

Disorders for RGL4 Gene

No disorders were found for RGL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL4 Gene

Publications for RGL4 Gene

  1. Human rgr: transforming activity and alteration in T-cell malignancies. (PMID: 12140761) Leonardi P … Pellicer A (Oncogene 2002) 3 4
  2. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. (PMID: 10851075) Hernandez-Muñoz I … Pellicer A (Oncogene 2000) 2 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  4. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. (PMID: 9178890) D'Adamo DR … Pellicer A (Oncogene 1997) 2 3
  5. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3

Products for RGL4 Gene

Sources for RGL4 Gene