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Aliases for RGL4 Gene

Aliases for RGL4 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 4 2 3 5
  • RalGDS Related Oncogene 2 3
  • RalGDS-Like 4 3 4
  • Rgr 3 4
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 4 4
  • Ral-GDS Related Protein Rgr 3
  • Ral-GDS-Related Protein 3
  • HRGR 4

External Ids for RGL4 Gene

Previous GeneCards Identifiers for RGL4 Gene

  • GC22P022360
  • GC22P024030
  • GC22P007020

Summaries for RGL4 Gene

Entrez Gene Summary for RGL4 Gene

  • This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]

GeneCards Summary for RGL4 Gene

RGL4 (Ral Guanine Nucleotide Dissociation Stimulator Like 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

Additional gene information for RGL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL4 Gene

Genomics for RGL4 Gene

GeneHancer (GH) Regulatory Elements for RGL4 Gene

Promoters and enhancers for RGL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I023690 Promoter 0.5 EPDnew 550.8 +2.9 2860 0.1 RGL4 ENSG00000272578 ENSG00000273000 GUSBP11
GH22I023772 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +86.4 86414 4.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ETS1 GLIS2 RXRA MMP11 VPREB3 ZNF70 SMARCB1 GUSBP11 RGL4 CHCHD10 ENSG00000273295
GH22I023716 Promoter/Enhancer 1.6 Ensembl ENCODE 11.5 +29.0 29036 1.5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ENSG00000272578 GUSBP11 ENSG00000273000 ZNF70 ENSG00000234353 SPECC1L VPREB3 C22orf15 RGL4 MMP11
GH22I023518 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -166.6 -166570 6.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 GLIS2 ATF7 SP5 LINC02557 RGL4 GUSBP11 ENSG00000227755 DDT LINC01659 ENSG00000272787 RSPH14 BCR GNAZ
GH22I023511 Enhancer 0.7 dbSUPER 10.7 -174.7 -174715 4.7 CTCF BCOR ZMYM3 ZFHX2 ZNF23 POLR2A SCRT2 EGR2 SCRT1 ZNF623 LINC02557 RGL4 GUSBP11 ZDHHC8P1 ENSG00000227755 DDT LINC01659 LINC01658
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGL4 gene promoter:

Genomic Locations for RGL4 Gene

Genomic Locations for RGL4 Gene
11,570 bases
Plus strand

Genomic View for RGL4 Gene

Genes around RGL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL4 Gene

Proteins for RGL4 Gene

  • Protein details for RGL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral-GDS-related protein
    Protein Accession:
    Secondary Accessions:
    • Q495L8

    Protein attributes for RGL4 Gene

    473 amino acids
    Molecular mass:
    52346 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01109.1; Type=Frameshift; Positions=61; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL4 Gene


neXtProt entry for RGL4 Gene

Post-translational modifications for RGL4 Gene

No data available for DME Specific Peptides for RGL4 Gene

Domains & Families for RGL4 Gene

Gene Families for RGL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for RGL4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGL4: view

No data available for UniProtKB/Swiss-Prot for RGL4 Gene

Function for RGL4 Gene

Gene Ontology (GO) - Molecular Function for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RGL4: view
genes like me logo Genes that share phenotypes with RGL4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGL4 Gene

Localization for RGL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGL4 Gene

Cytoplasmic vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL4 gene
Compartment Confidence
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with RGL4: view

Pathways & Interactions for RGL4 Gene

genes like me logo Genes that share pathways with RGL4: view

Pathways by source for RGL4 Gene

1 GeneTex pathway for RGL4 Gene
1 BioSystems pathway for RGL4 Gene

Gene Ontology (GO) - Biological Process for RGL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with RGL4: view

No data available for SIGNOR curated interactions for RGL4 Gene

Drugs & Compounds for RGL4 Gene

No Compound Related Data Available

Transcripts for RGL4 Gene

Unigene Clusters for RGL4 Gene

Ral guanine nucleotide dissociation stimulator-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - -
SP7: -

Relevant External Links for RGL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL4 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for RGL4 Gene

This gene is overexpressed in Tlymphocyte (45.5), Fetal gut (14.8), and NK cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGL4 Gene:


SOURCE GeneReport for Unigene cluster for RGL4 Gene:

genes like me logo Genes that share expression patterns with RGL4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL4 Gene

Orthologs for RGL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGL4 33 34
  • 96.48 (n)
(Canis familiaris)
Mammalia -- 34
  • 39 (a)
-- 34
  • 38 (a)
-- 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia RGL4 34
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 10 (a)
Species where no ortholog for RGL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RGL4 Gene

Gene Tree for RGL4 (if available)
Gene Tree for RGL4 (if available)

Paralogs for RGL4 Gene Pseudogenes for RGL4 Gene

genes like me logo Genes that share paralogs with RGL4: view

Variants for RGL4 Gene

Sequence variations from dbSNP and Humsavar for RGL4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000397086 -- 23,691,627(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000608932 -- 23,690,629(+) G/C upstream_transcript_variant
rs1000739896 -- 23,695,445(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000760817 -- 23,695,102(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000791273 -- 23,695,615(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RGL4 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855
nsv526567 CNV gain 19592680
nsv1110863 OTHER inversion 24896259
nsv1066891 CNV gain 25217958
nsv1062411 CNV gain 25217958
esv3893461 CNV gain 25118596
esv3893457 CNV gain 25118596
esv3575443 CNV gain 25503493
esv2751941 CNV gain 17911159
esv2724041 CNV deletion 23290073
dgv8039n54 CNV gain 21841781
dgv4528n100 CNV gain 25217958

Variation tolerance for RGL4 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL4 Gene

Disorders for RGL4 Gene

Additional Disease Information for RGL4

No disorders were found for RGL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL4 Gene

Publications for RGL4 Gene

  1. Human rgr: transforming activity and alteration in T-cell malignancies. (PMID: 12140761) Leonardi P … Pellicer A (Oncogene 2002) 3 4 58
  2. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. (PMID: 10851075) Hernandez-Muñoz I … Pellicer A (Oncogene 2000) 2 3 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  4. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. (PMID: 9178890) D'Adamo DR … Pellicer A (Oncogene 1997) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RGL4 Gene

Sources for RGL4 Gene

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