Aliases for RGL3 Gene

Aliases for RGL3 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 3 2 3 5
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 3 3 4
  • RalGDS-Like 3 3 4
  • RalGEF-Like Protein 3, Mouse Homolog 3
  • FLJ32585 2
  • RGL3 5

External Ids for RGL3 Gene

Previous GeneCards Identifiers for RGL3 Gene

  • GC19U990227
  • GC19M011727
  • GC19M011349
  • GC19M011365
  • GC19M011356
  • GC19M011495
  • GC19M011080

Summaries for RGL3 Gene

GeneCards Summary for RGL3 Gene

RGL3 (Ral Guanine Nucleotide Dissociation Stimulator Like 3) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling_RalB regulation pathway. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000285245.

UniProtKB/Swiss-Prot Summary for RGL3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGL3 Gene

Genomics for RGL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011417 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.7 +0.5 541 2 HNRNPL RBFOX2 EZH2 GABPA ZFX TAF1 POLR2A MBD1 SREBF2 ZFHX2 NONHSAG024840.2 RGL3 lnc-CCDC151-1 lnc-CCDC151-2 EPOR
GH19J011380 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 +37.0 36959 5.6 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 TEAD4 PRDM10 ZNF629 TFE3 EPOR NONHSAG024835.2 ILF3 TIMM29 KRI1 ZNF136 ZNF844 ZNF441 RGL3 ZNF433
GH19J011360 Promoter/Enhancer 1 Ensembl ENCODE 17.4 +57.4 57350 1.7 CTCF REST ZIC2 RBFOX2 SP1 POLR2A ZNF341 SCRT2 NRF1 MGA RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19J011354 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 7.2 +63.4 63449 2.2 ARHGAP35 HNRNPL CREB1 PRDM10 KDM1A ZNF692 TARDBP MTA2 ZSCAN4 RBFOX2 PLPPR2 ZNF627 ZNF625 ZNF20 ILF3 ZNF844 ENSG00000242615 ZNF136 ZNF439 ZNF44
GH19J011386 Enhancer 0.7 ENCODE 20.8 +32.0 31982 1.1 GATAD2A CEBPA KMT2B SOX13 FOXA2 CUX1 ZNF792 SAP130 SPI1 ZGPAT RGL3 PLPPR2 KANK2 EPOR lnc-EPOR-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGL3

Top Transcription factor binding sites by QIAGEN in the RGL3 gene promoter:
  • AP-2alpha
  • CREB
  • deltaCREB
  • ER-alpha
  • GATA-3
  • Hlf
  • MRF-2
  • Pax-5
  • USF-1
  • USF1

Genomic Locations for RGL3 Gene

Genomic Locations for RGL3 Gene
chr19:11,384,341-11,419,342
(GRCh38/hg38)
Size:
35,002 bases
Orientation:
Minus strand
chr19:11,495,017-11,530,018
(GRCh37/hg19)
Size:
35,002 bases
Orientation:
Minus strand

Genomic View for RGL3 Gene

Genes around RGL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL3 Gene

Proteins for RGL3 Gene

  • Protein details for RGL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIN7-RGL3_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 3
    Protein Accession:
    Q3MIN7
    Secondary Accessions:
    • B5ME84
    • B7ZL22
    • Q0P6G0

    Protein attributes for RGL3 Gene

    Size:
    710 amino acids
    Molecular mass:
    78079 Da
    Quaternary structure:
    • Interacts with GTP-bound forms of RIT1, HRAS and MRAS.
    SequenceCaution:
    • Sequence=AAH14426.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL3 Gene

Post-translational modifications for RGL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGL3 Gene

Domains & Families for RGL3 Gene

Gene Families for RGL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGL3 Gene

InterPro:
Blocks:
  • Guanine-nucleotide dissociation stimulator CDC25
  • RA domain
ProtoNet:

Suggested Antigen Peptide Sequences for RGL3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54824, highly similar to Homo sapiens ral guanine nucleotide dissociation stimulator-like 3 (RGL3), mRNA (B4DE00_HUMAN)
  • RGL3 protein (B7ZL22_HUMAN)
  • Ral guanine nucleotide dissociation stimulator-like 3 (RGL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3MIN7

UniProtKB/Swiss-Prot:

RGL3_HUMAN :
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
Domain:
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
genes like me logo Genes that share domains with RGL3: view

Function for RGL3 Gene

Molecular function for RGL3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Phenotypes From GWAS Catalog for RGL3 Gene

Gene Ontology (GO) - Molecular Function for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0008321 Ral guanyl-nucleotide exchange factor activity IEA --
GO:0017016 Ras GTPase binding IEA --
GO:0031267 small GTPase binding IEA --
genes like me logo Genes that share ontologies with RGL3: view
genes like me logo Genes that share phenotypes with RGL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGL3 Gene

Localization for RGL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL3 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGL3 Gene

Pathways & Interactions for RGL3 Gene

PathCards logo

SuperPathways for RGL3 Gene

SuperPathway Contained pathways
1 Cytoskeleton remodeling_RalB regulation pathway
-
genes like me logo Genes that share pathways with RGL3: view

Pathways by source for RGL3 Gene

1 GeneGo (Thomson Reuters) pathway for RGL3 Gene
  • Cytoskeleton remodeling_RalB regulation pathway

Gene Ontology (GO) - Biological Process for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for SIGNOR curated interactions for RGL3 Gene

Drugs & Compounds for RGL3 Gene

(3) Drugs for RGL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGL3: view

Transcripts for RGL3 Gene

mRNA/cDNA for RGL3 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL3

Alternative Splicing Database (ASD) splice patterns (SP) for RGL3 Gene

No ASD Table

Relevant External Links for RGL3 Gene

GeneLoc Exon Structure for
RGL3

Expression for RGL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL3 Gene

This gene is overexpressed in Thyroid (x8.3) and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for RGL3 Gene

This gene is overexpressed in Urine (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGL3 Gene



Protein tissue co-expression partners for RGL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGL3

SOURCE GeneReport for Unigene cluster for RGL3 Gene:

Hs.375142

Evidence on tissue expression from TISSUES for RGL3 Gene

  • Kidney(4.4)
  • Liver(4.2)
  • Lung(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with RGL3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL3 Gene

Orthologs for RGL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGL3 30 31
  • 99.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGL3 30 31
  • 84.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGL3 30 31
  • 83.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgl3 30 17 31
  • 80.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgl3 30
  • 79.56 (n)
Oppossum
(Monodelphis domestica)
Mammalia RGL3 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGL3 31
  • 53 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGL3 31
  • 45 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rgl3a 31
  • 34 (a)
OneToMany
RGL3 (1 of 2) 31
  • 31 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Rgl 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rgl-1 31
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for RGL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RGL3 Gene

ENSEMBL:
Gene Tree for RGL3 (if available)
TreeFam:
Gene Tree for RGL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGL3: view image

Paralogs for RGL3 Gene

(7) SIMAP similar genes for RGL3 Gene using alignment to 6 proteins:

  • RGL3_HUMAN
  • H3BN42_HUMAN
  • H3BQS8_HUMAN
  • H3BRW0_HUMAN
  • K7EIS7_HUMAN
  • K7EMV7_HUMAN
genes like me logo Genes that share paralogs with RGL3: view

Variants for RGL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGL3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs160838 - p.Ala164Val
rs167479 - p.Pro162His
rs2291516 - p.Arg615Cys

Additional dbSNP identifiers (rs#s) for RGL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGL3 Gene

Variant ID Type Subtype PubMed ID
esv1464086 CNV deletion 17803354
esv2673946 CNV deletion 23128226
esv3556030 CNV deletion 23714750
esv3643671 CNV loss 21293372
esv3643672 CNV loss 21293372
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897
nsv953975 CNV deletion 24416366

Variation tolerance for RGL3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.14; 97.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL3 Gene

Disorders for RGL3 Gene

Additional Disease Information for RGL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RGL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL3 Gene

Publications for RGL3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4

Products for RGL3 Gene

Sources for RGL3 Gene