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Aliases for RGL3 Gene

Aliases for RGL3 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 3 2 3 5
  • RalGDS-Like 3 4

External Ids for RGL3 Gene

Previous GeneCards Identifiers for RGL3 Gene

  • GC19U990227
  • GC19M011727
  • GC19M011349
  • GC19M011365
  • GC19M011356
  • GC19M011495
  • GC19M011080

Summaries for RGL3 Gene

GeneCards Summary for RGL3 Gene

RGL3 (Ral Guanine Nucleotide Dissociation Stimulator Like 3) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling_RalB regulation pathway. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RGL3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Additional gene information for RGL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGL3 Gene

Genomics for RGL3 Gene

GeneHancer (GH) Regulatory Elements for RGL3 Gene

Promoters and enhancers for RGL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I011417 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.5 532 1.9 SREBF2 ARID4B SIN3A PPARG GABPA E2F1 ZFHX2 ZGPAT POLR2A ETV4 RGL3 ENSG00000202357
GH19I011379 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.1 +37.0 36976 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 EPOR KRI1 ILF3 TIMM29 ZNF44 ZNF136 ZNF433 ZNF878 ZNF20 ZNF563
GH19I011386 Enhancer 0.8 Ensembl ENCODE 20.8 +32.0 31982 1.1 SOX13 GATAD2A TFAP4 PKNOX1 FOXA2 SAP130 NFIL3 CEBPA CUX1 ZBTB33 RGL3 PLPPR2 KANK2 EPOR GC19P011409
GH19I011360 Enhancer 0.9 Ensembl ENCODE 17.4 +57.6 57620 2.2 CTCF KLF1 MAX SIN3A ZIC2 HIC1 GLIS2 MTA3 POLR2A SCRT2 RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19I011354 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.2 +63.6 63631 1.9 HDGF PKNOX1 ARNT SIN3A GLI4 ZNF2 ZBTB7B ZNF48 TCF12 ZNF302 PLPPR2 ZNF627 ZNF625 ZNF441 ZNF20 ILF3 RPL18AP13 ZNF844 ZNF491 ENSG00000242615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGL3 gene promoter:

Genomic Locations for RGL3 Gene

Genomic Locations for RGL3 Gene
chr19:11,384,341-11,419,342
(GRCh38/hg38)
Size:
35,002 bases
Orientation:
Minus strand
chr19:11,495,017-11,530,018
(GRCh37/hg19)

Genomic View for RGL3 Gene

Genes around RGL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL3 Gene

Proteins for RGL3 Gene

  • Protein details for RGL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIN7-RGL3_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 3
    Protein Accession:
    Q3MIN7
    Secondary Accessions:
    • B5ME84
    • B7ZL22
    • Q0P6G0

    Protein attributes for RGL3 Gene

    Size:
    710 amino acids
    Molecular mass:
    78079 Da
    Quaternary structure:
    • Interacts with GTP-bound forms of RIT1, HRAS and MRAS.
    SequenceCaution:
    • Sequence=AAH14426.1; Type=Frameshift; Positions=323; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL3 Gene

Post-translational modifications for RGL3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RGL3 Gene

Domains & Families for RGL3 Gene

Gene Families for RGL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q3MIN7

UniProtKB/Swiss-Prot:

RGL3_HUMAN :
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
Domain:
  • The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.
genes like me logo Genes that share domains with RGL3: view

Function for RGL3 Gene

Molecular function for RGL3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).

Phenotypes From GWAS Catalog for RGL3 Gene

Gene Ontology (GO) - Molecular Function for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008321 Ral guanyl-nucleotide exchange factor activity IEA --
GO:0017016 Ras GTPase binding IEA --
GO:0031267 small GTPase binding IEA --
genes like me logo Genes that share ontologies with RGL3: view
genes like me logo Genes that share phenotypes with RGL3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGL3 Gene

Localization for RGL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL3 gene
Compartment Confidence
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL3 Gene

Pathways & Interactions for RGL3 Gene

genes like me logo Genes that share pathways with RGL3: view

Pathways by source for RGL3 Gene

1 GeneGo (Thomson Reuters) pathway for RGL3 Gene

Gene Ontology (GO) - Biological Process for RGL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGL3: view

No data available for SIGNOR curated interactions for RGL3 Gene

Drugs & Compounds for RGL3 Gene

(3) Drugs for RGL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGL3: view

Transcripts for RGL3 Gene

Unigene Clusters for RGL3 Gene

Ral guanine nucleotide dissociation stimulator-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGL3 Gene

No ASD Table

Relevant External Links for RGL3 Gene

GeneLoc Exon Structure for
RGL3
ECgene alternative splicing isoforms for
RGL3

Expression for RGL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGL3 Gene

This gene is overexpressed in Thyroid (x8.3) and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for RGL3 Gene

This gene is overexpressed in Urine (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGL3 Gene



Protein tissue co-expression partners for RGL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGL3 Gene:

RGL3

SOURCE GeneReport for Unigene cluster for RGL3 Gene:

Hs.375142

Evidence on tissue expression from TISSUES for RGL3 Gene

  • Kidney(4.3)
  • Lung(4.2)
  • Heart(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RGL3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL3 Gene

Orthologs for RGL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGL3 33 34
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia RGL3 33 34
  • 84.17 (n)
cow
(Bos Taurus)
Mammalia RGL3 33 34
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Rgl3 33 16 34
  • 80.31 (n)
rat
(Rattus norvegicus)
Mammalia Rgl3 33
  • 79.56 (n)
oppossum
(Monodelphis domestica)
Mammalia RGL3 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGL3 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGL3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rgl3a 34
  • 34 (a)
OneToMany
RGL3 (1 of 2) 34
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rgl 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgl-1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for RGL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGL3 Gene

ENSEMBL:
Gene Tree for RGL3 (if available)
TreeFam:
Gene Tree for RGL3 (if available)

Paralogs for RGL3 Gene

genes like me logo Genes that share paralogs with RGL3: view

Variants for RGL3 Gene

Sequence variations from dbSNP and Humsavar for RGL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs544310246 benign, Ciliary dyskinesia, primary, 30 11,420,918(-) C/A/T upstream_transcript_variant
rs1000279978 -- 11,408,890(-) G/A intron_variant
rs1000471249 -- 11,408,584(-) C/A intron_variant
rs1000538774 -- 11,395,367(-) G/A intron_variant
rs1000614110 -- 11,407,725(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGL3 Gene

Variant ID Type Subtype PubMed ID
nsv953975 CNV deletion 24416366
nsv833752 CNV loss 17160897
nsv519802 CNV loss 19592680
esv3643672 CNV loss 21293372
esv3643671 CNV loss 21293372
esv3556030 CNV deletion 23714750
esv2673946 CNV deletion 23128226
esv1464086 CNV deletion 17803354

Variation tolerance for RGL3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.14; 97.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL3 Gene

Disorders for RGL3 Gene

Additional Disease Information for RGL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGL3 Gene

Publications for RGL3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 58
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 58

Products for RGL3 Gene

Sources for RGL3 Gene

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