Aliases for RGL2 Gene

Aliases for RGL2 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 2 2 3 5
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 2 3 4
  • Ras-Associated Protein RAB2L 3 4
  • RalGDS-Like Factor 3 4
  • RalGDS-Like 2 3 4
  • RAB2L 3 4
  • RAB2, Member RAS Oncogene Family-Like 2
  • GDS-Related Protein 3
  • HKE1.5 3
  • KE1.5 3

External Ids for RGL2 Gene

Previous HGNC Symbols for RGL2 Gene

  • RAB2L

Previous GeneCards Identifiers for RGL2 Gene

  • GC06M033307
  • GC06M033367
  • GC06M033259
  • GC06M033001

Summaries for RGL2 Gene

GeneCards Summary for RGL2 Gene

RGL2 (Ral Guanine Nucleotide Dissociation Stimulator Like 2) is a Protein Coding gene. Diseases associated with RGL2 include Tumoral Calcinosis, Normophosphatemic, Familial and Familial Tumoral Calcinosis. Among its related pathways are Ras signaling pathway and G-protein signaling_K-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot Summary for RGL2 Gene

  • Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).

Gene Wiki entry for RGL2 Gene

Additional gene information for RGL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGL2 Gene

Genomics for RGL2 Gene

GeneHancer (GH) Regulatory Elements for RGL2 Gene

Promoters and enhancers for RGL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGL2

Top Transcription factor binding sites by QIAGEN in the RGL2 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-5
  • Sp1
  • STAT3

Genomic Locations for RGL2 Gene

Genomic Locations for RGL2 Gene
chr6:33,291,654-33,299,452
(GRCh38/hg38)
Size:
7,799 bases
Orientation:
Minus strand
chr6:33,259,431-33,267,176
(GRCh37/hg19)
Size:
7,746 bases
Orientation:
Minus strand

Genomic View for RGL2 Gene

Genes around RGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL2 Gene

Proteins for RGL2 Gene

  • Protein details for RGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15211-RGL2_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 2
    Protein Accession:
    O15211
    Secondary Accessions:
    • B4DG72
    • Q5STK0
    • Q9Y3F3

    Protein attributes for RGL2 Gene

    Size:
    777 amino acids
    Molecular mass:
    83549 Da
    Quaternary structure:
    • Interacts with SAMD9.

    Alternative splice isoforms for RGL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGL2 Gene

Post-translational modifications for RGL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGL2 Gene

No data available for DME Specific Peptides for RGL2 Gene

Domains & Families for RGL2 Gene

Gene Families for RGL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RGL2 Gene

Blocks:
  • RA domain
  • Guanine-nucleotide dissociation stimulator CDC25
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGL2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53778, highly similar to Ral guanine nucleotide dissociation stimulator-like 2 (B4DG72_HUMAN)
  • RGL2 protein (Q4G0R5_HUMAN)
  • GDS-related protein (Q54AJ0_HUMAN)
  • RalGDS-like (Q92942_HUMAN)
  • RGL2 protein (Q9BSI0_HUMAN)
genes like me logo Genes that share domains with RGL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGL2 Gene

Function for RGL2 Gene

Molecular function for RGL2 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).

Phenotypes From GWAS Catalog for RGL2 Gene

Gene Ontology (GO) - Molecular Function for RGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity NAS 8976381
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGL2: view
genes like me logo Genes that share phenotypes with RGL2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGL2 Gene

Localization for RGL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RGL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL2 Gene

Pathways & Interactions for RGL2 Gene

PathCards logo

SuperPathways for RGL2 Gene

SuperPathway Contained pathways
1 Ras signaling pathway
2 Cytoskeleton remodeling_RalA regulation pathway
-
3 G-protein signaling N-RAS regulation pathway
.52
4 G-protein signaling_K-RAS regulation pathway
-
genes like me logo Genes that share pathways with RGL2: view

Pathways by source for RGL2 Gene

1 KEGG pathway for RGL2 Gene
3 GeneGo (Thomson Reuters) pathways for RGL2 Gene
  • Cytoskeleton remodeling_RalA regulation pathway
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_K-RAS regulation pathway
1 GeneTex pathway for RGL2 Gene

Gene Ontology (GO) - Biological Process for RGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007265 Ras protein signal transduction NAS 8976381
GO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
genes like me logo Genes that share ontologies with RGL2: view

No data available for SIGNOR curated interactions for RGL2 Gene

Drugs & Compounds for RGL2 Gene

(3) Drugs for RGL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGL2: view

Transcripts for RGL2 Gene

mRNA/cDNA for RGL2 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGL2 Gene

No ASD Table

Relevant External Links for RGL2 Gene

GeneLoc Exon Structure for
RGL2

Expression for RGL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGL2 Gene

This gene is overexpressed in Heart (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGL2 Gene



Protein tissue co-expression partners for RGL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGL2

SOURCE GeneReport for Unigene cluster for RGL2 Gene:

Hs.509622

Evidence on tissue expression from TISSUES for RGL2 Gene

  • Nervous system(4.7)
  • Liver(4.1)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with RGL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL2 Gene

Orthologs for RGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGL2 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RGL2 31 30
  • 91.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RGL2 31 30
  • 89.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgl2 30
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Rgl2 17 31 30
  • 87.31 (n)
oppossum
(Monodelphis domestica)
Mammalia RGL2 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RGL2 31
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgl2 30
  • 51.84 (n)
zebrafish
(Danio rerio)
Actinopterygii rgl2 31 30
  • 52.86 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rgl 31
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgl-1 31
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
OneToMany
Species where no ortholog for RGL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGL2 Gene

ENSEMBL:
Gene Tree for RGL2 (if available)
TreeFam:
Gene Tree for RGL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGL2: view image

Paralogs for RGL2 Gene

(9) SIMAP similar genes for RGL2 Gene using alignment to 8 proteins:

  • RGL2_HUMAN
  • A2AB89_HUMAN
  • B4DG72_HUMAN
  • I7H119_HUMAN
  • Q4G0R5_HUMAN
  • Q92942_HUMAN
  • Q9BSI0_HUMAN
  • Q9BWF0_HUMAN
genes like me logo Genes that share paralogs with RGL2: view

Variants for RGL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGL2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
784072 Benign: not provided 33,293,257(-) C/G MISSENSE_VARIANT
784073 Benign: not provided 33,297,068(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
rs34022110 - p.Pro598Leu
rs35273540 - p.Gly705Glu

Additional dbSNP identifiers (rs#s) for RGL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGL2 Gene

Variant ID Type Subtype PubMed ID
esv3353999 CNV duplication 20981092
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv830634 CNV loss 17160897
nsv830635 CNV loss 17160897

Variation tolerance for RGL2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL2 Gene

Human Gene Mutation Database (HGMD)
RGL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL2 Gene

Disorders for RGL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RGL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tumoral calcinosis, normophosphatemic, familial
  • nftc
familial tumoral calcinosis
calcinosis
  • pathologic calcification
- elite association - COSMIC cancer census association via MalaCards
Search RGL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGL2 Gene

Publications for RGL2 Gene