Aliases for RGL1 Gene

Aliases for RGL1 Gene

  • Ral Guanine Nucleotide Dissociation Stimulator Like 1 2 3 5
  • RGL 2 3 4
  • Ral Guanine Nucleotide Dissociation Stimulator-Like 1 3 4
  • RalGDS-Like 1 3 4
  • KIAA0959 4
  • RGL1 5

External Ids for RGL1 Gene

Previous GeneCards Identifiers for RGL1 Gene

  • GC01P180845
  • GC01P180336
  • GC01P181871
  • GC01P183605
  • GC01P154841

Summaries for RGL1 Gene

GeneCards Summary for RGL1 Gene

RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1) is a Protein Coding gene. Diseases associated with RGL1 include Nutritional Optic Neuropathy and Toxic Optic Neuropathy. Among its related pathways are Ras signaling pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ral guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot Summary for RGL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGL1 Gene

Genomics for RGL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J183804 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.1 +170.5 170549 4.8 ZNF207 ZNF600 POLR2A CEBPA SIN3A TRIM22 ZNF217 CTBP1 SMAD4 CUX1 RGL1 DHX9 ENSG00000227554 SMG7 NCF2 ARPC5 piR-57134-008 RF01061-019 APOBEC4 COLGALT2
GH01J183630 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -2.1 -2084 6.8 SP1 ZNF207 IKZF1 MYC ZNF600 SSRP1 JUND ZNF580 POLR2A CEBPA ARPC5 HSALNG0008981 RGL1 lnc-APOBEC4-3 NCF2 LAMC1 MN308837
GH01J183637 Promoter 0.3 Ensembl 250.7 +1.7 1716 0.4 RGL1 ARPC5 APOBEC4 lnc-APOBEC4-2
GH01J183602 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -31.0 -30979 4.9 SP1 ZNF207 JUND ATF2 YY1 BCL11A CTCF ZNF592 TRIM22 FOXA2 NCF2 ARPC5 LAMC1 RGL1 APOBEC4 SMG7 LOC107985235 HSALNG0008978 MN296899
GH01J184036 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3 +400.8 400849 2.7 NCOR1 MYC ZNF600 IKZF1 ZNF580 ZNF592 ZNF223 ZIC2 ZBTB10 NONO COLGALT2 SMG7 TSEN15 RGL1 piR-45035-015 APOBEC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGL1

Top Transcription factor binding sites by QIAGEN in the RGL1 gene promoter:
  • AhR
  • AML1a
  • Arnt
  • C/EBPalpha
  • Cdc5
  • Ik-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT4

Genomic Locations for RGL1 Gene

Latest Assembly
292,448 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
292,423 bases
Plus strand

(GRCh37/hg19 by Ensembl)
292,446 bases
Plus strand

Genomic View for RGL1 Gene

Genes around RGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGL1 Gene

Proteins for RGL1 Gene

  • Protein details for RGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ral guanine nucleotide dissociation stimulator-like 1
    Protein Accession:
    Secondary Accessions:
    • Q5SXQ2
    • Q5SXQ6
    • Q9HBY3
    • Q9HBY4
    • Q9NZL5
    • Q9UG43
    • Q9Y2G6

    Protein attributes for RGL1 Gene

    768 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    • Interacts with Ras.
    • Sequence=BAA76803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RGL1 Gene


neXtProt entry for RGL1 Gene

Post-translational modifications for RGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGL1 Gene

Domains & Families for RGL1 Gene

Gene Families for RGL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGL1 Gene

Suggested Antigen Peptide Sequences for RGL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50518, highly similar to Ral guanine nucleotide dissociation stimulator-like 1 (B7Z2W5_HUMAN)
  • Ral guanine nucleotide dissociation stimulator-like 1, isoform CRA_b (Q5SXQ6_HUMAN)
  • Ral guanine nucleotide dissociation stimulator-like 1 (RGL1_HUMAN)
genes like me logo Genes that share domains with RGL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGL1 Gene

Function for RGL1 Gene

Molecular function for RGL1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor.

Phenotypes From GWAS Catalog for RGL1 Gene

Gene Ontology (GO) - Molecular Function for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity NAS 10760592
GO:0005515 protein binding IPI 20936779
GO:0008321 Ral guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RGL1: view
genes like me logo Genes that share phenotypes with RGL1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGL1 Gene

Localization for RGL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGL1 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RGL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGL1 Gene

Pathways & Interactions for RGL1 Gene

genes like me logo Genes that share pathways with RGL1: view

Pathways by source for RGL1 Gene

3 GeneGo (Thomson Reuters) pathways for RGL1 Gene
  • Cytoskeleton remodeling_RalA regulation pathway
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_K-RAS regulation pathway
1 GeneTex pathway for RGL1 Gene

Gene Ontology (GO) - Biological Process for RGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction NAS 10760592
GO:0019216 regulation of lipid metabolic process TAS --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with RGL1: view

No data available for SIGNOR curated interactions for RGL1 Gene

Drugs & Compounds for RGL1 Gene

(3) Drugs for RGL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for RGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGL1: view

Transcripts for RGL1 Gene

mRNA/cDNA for RGL1 Gene

17 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGL1

Alternative Splicing Database (ASD) splice patterns (SP) for RGL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -

Relevant External Links for RGL1 Gene

GeneLoc Exon Structure for

Expression for RGL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGL1 Gene

This gene is overexpressed in Blymphocyte (53.5) and Gallbladder (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGL1 Gene

Protein tissue co-expression partners for RGL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGL1

SOURCE GeneReport for Unigene cluster for RGL1 Gene:


mRNA Expression by UniProt/SwissProt for RGL1 Gene:

Tissue specificity: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis.

Evidence on tissue expression from TISSUES for RGL1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with RGL1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGL1 Gene

Orthologs for RGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGL1 29 30
  • 97.14 (n)
(Canis familiaris)
Mammalia RGL1 29 30
  • 93.57 (n)
(Bos Taurus)
Mammalia RGL1 29 30
  • 92.28 (n)
(Monodelphis domestica)
Mammalia RGL1 30
  • 91 (a)
(Mus musculus)
Mammalia Rgl1 29 16 30
  • 89.86 (n)
(Rattus norvegicus)
Mammalia Rgl1 29
  • 89.01 (n)
(Ornithorhynchus anatinus)
Mammalia RGL1 30
  • 82 (a)
(Gallus gallus)
Aves RGL1 29 30
  • 81.56 (n)
(Anolis carolinensis)
Reptilia -- 30
  • 72 (a)
-- 30
  • 60 (a)
(Danio rerio)
Actinopterygii rgl1 29 30
  • 66.53 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rgl 29 30
  • 48.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010782 29
  • 47.22 (n)
(Caenorhabditis elegans)
Secernentea rgl-1 29 30
  • 46.52 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 25 (a)
Species where no ortholog for RGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RGL1 Gene

Gene Tree for RGL1 (if available)
Gene Tree for RGL1 (if available)
Evolutionary constrained regions (ECRs) for RGL1: view image
Alliance of Genome Resources:
Additional Orthologs for RGL1

Paralogs for RGL1 Gene

(10) SIMAP similar genes for RGL1 Gene using alignment to 3 proteins:

  • B7Z2W5_HUMAN
  • F5H6U6_HUMAN
genes like me logo Genes that share paralogs with RGL1: view

Variants for RGL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs16861381 Benign: not provided 183,647,883(+) T/C
NM_203454.3(APOBEC4):c.899A>G (p.Asp300Gly)
rs16861392 Benign: not provided 183,648,236(+) C/T
NM_203454.3(APOBEC4):c.546G>A (p.Pro182=)
rs73049207 Benign: not provided 183,912,275(+) A/G
rs76778886 Benign: not provided 183,647,821(+) T/C
NM_203454.3(APOBEC4):c.961A>G (p.Asn321Asp)
rs79543078 Benign: not provided 183,648,195(+) G/C
NM_203454.3(APOBEC4):c.587C>G (p.Ser196Cys)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RGL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RGL1 Gene

Variant ID Type Subtype PubMed ID
esv1709028 CNV insertion 17803354
esv2720140 CNV deletion 23290073
esv3302732 CNV tandem duplication 20981092
esv3588116 CNV loss 21293372
esv3588117 CNV gain 21293372
nsv1133030 OTHER inversion 24896259
nsv441723 CNV gain 18776908
nsv477962 CNV novel sequence insertion 20440878
nsv478839 CNV novel sequence insertion 20440878
nsv525878 CNV gain 19592680
nsv825598 CNV gain 20364138
nsv832015 CNV gain 17160897
nsv832026 CNV gain+loss 17160897

Variation tolerance for RGL1 Gene

Residual Variation Intolerance Score: 6.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGL1 Gene

Disorders for RGL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RGL1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search RGL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGL1

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGL1 Gene

Publications for RGL1 Gene

  1. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PMID: 10760592) Sood R … Bonner TI (Biochimica et biophysica acta 2000) 2 3 4 22
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R … McGuffin P (The American journal of psychiatry 2010) 3 40
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 40

Products for RGL1 Gene

Sources for RGL1 Gene