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This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Diseases associated with RGCC include Renal Fibrosis and Hyper Ige Syndrome. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein kinase binding and R-SMAD binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19162005 |
GO:0019901 | protein kinase binding | IEA,ISS | -- |
GO:0030295 | protein kinase activator activity | IDA | 11687586 |
GO:0070412 | R-SMAD binding | IPI | 21307346 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 11687586 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 11687586 |
GO:0005813 | centrosome | IDA | 17146433 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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2 | TP53 Regulates Transcription of Cell Cycle Genes | ||
3 | Regulation of TP53 Activity | ||
4 | Direct p53 effectors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001100 | negative regulation of exit from mitosis | IDA | 17146433 |
GO:0001937 | negative regulation of endothelial cell proliferation | IDA | 19652095 |
GO:0003331 | positive regulation of extracellular matrix constituent secretion | IDA | 19158077 |
GO:0006956 | complement activation | IMP | 19162005 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RGCC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGC148992 31 |
|
OneToOne | |
RGCC 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Rgcc 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rgcc 30 |
|
||
Dog (Canis familiaris) |
Mammalia | RGCC 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RGCC 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RGCC 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | C1H13ORF15 30 |
|
||
RGCC 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | RGCC 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rgcc 30 |
|
||
Str.17679 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | rgcc 30 31 |
|
OneToOne | |
sbcb658 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1634n100 | CNV | gain | 25217958 |
esv3580617 | CNV | loss | 25503493 |
nsv509504 | CNV | insertion | 20534489 |
Disorder | Aliases | PubMed IDs |
---|---|---|
renal fibrosis |
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|
hyper ige syndrome |
|
|
ovarian cancer |
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