Aliases for RGCC Gene
External Ids for RGCC Gene
Previous HGNC Symbols for RGCC Gene
Previous GeneCards Identifiers for RGCC Gene
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGCC Gene
RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Diseases associated with RGCC include Renal Fibrosis and Retinal Cancer. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein kinase binding and R-SMAD binding.
UniProtKB/Swiss-Prot for RGCC Gene
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.