Aliases for RFX4 Gene
External Ids for RFX4 Gene
Previous GeneCards Identifiers for RFX4 Gene
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
GeneCards Summary for RFX4 Gene
RFX4 (Regulatory Factor X4) is a Protein Coding gene. Diseases associated with RFX4 include Cellular Ependymoma. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is RFX6.
UniProtKB/Swiss-Prot Summary for RFX4 Gene
Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development.