Aliases for RFX3 Gene
Aliases for RFX3 Gene
External Ids for RFX3 Gene
- HGNC: 9984
- Entrez Gene: 5991
- Ensembl: ENSG00000080298
- OMIM: 601337
- UniProtKB: P48380
Previous GeneCards Identifiers for RFX3 Gene
- GC09M003378
- GC09M003205
Summaries for RFX3 Gene
-
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for RFX3 Gene
RFX3 (Regulatory Factor X3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is RFX2.
UniProtKB/Swiss-Prot for RFX3 Gene
-
Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430).
Additional gene information for RFX3 Gene
- Monarch Initiative
- Search for RFX3 at DataMed
- Search for RFX3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFX3 Gene
Genomics for RFX3 Gene
GeneHancer (GH) Regulatory Elements for RFX3 Gene
Promoters and enhancers for RFX3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J003523 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | -0.7 | -687 | 6.4 | PKNOX1 FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 | RFX3 RFX3-AS1 PUM3 GC09P003267 | |
| GH09J003473 | Promoter/Enhancer | 0.9 | EPDnew ENCODE | 650.2 | +52.4 | 52393 | 0.2 | MAX SPI1 | GC09P003471 PIR60517 RFX3 GC09P003267 | |
| GH09J002630 | Enhancer | 0.5 | ENCODE | 11.9 | +895.7 | 895748 | 0.2 | ZNF316 MAFF ZNF157 MAFG EMSY MAFK | RFX3 PUM3 VLDLR PIR48978 VLDLR-AS1 | |
| GH09J004499 | Enhancer | 0.9 | ENCODE dbSUPER | 6.1 | -975.7 | -975730 | 3.8 | FOXA2 NFIB MAX RAD21 YY1 EGR1 HNF4G RXRA REST GABPA | RFX3 SLC1A1 GC09P004528 GC09P004427 | |
| GH09J003507 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 2.4 | +17.2 | 17155 | 3.1 | SMAD1 FEZF1 YBX1 ZNF2 ZNF213 ATF7 RUNX3 TSHZ1 ZNF488 ZNF592 | RFX3 GC09P003480 GC09P003267 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RFX3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RFX3 gene promoter:
-
- E2F-1
- FOXD3
- E2F
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- AREB6
- C/EBPalpha
- Nkx2-5
Regulatory Element Products
Genomic Locations for RFX3 Gene
Genomic Locations for RFX3 Gene
- chr9:3,218,297-3,526,004
- (GRCh38/hg38)
- Size:
- 307,708 bases
- Orientation:
- Minus strand
- chr9:3,218,297-3,526,004
- (GRCh37/hg19)
- Size:
- 307,708 bases
- Orientation:
- Minus strand
Genomic View for RFX3 Gene
Genes around RFX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p24.2 by Entrez Gene
- 9p24.2 by HGNC
- 9p24.2 by Ensembl
RFX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RFX3 Gene
Proteins for RFX3 Gene
-
Protein details for RFX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48380-RFX3_HUMAN
- Recommended name:
- Transcription factor RFX3
- Protein Accession:
- P48380
- A8K0H5
- D3DRH8
- D3DRH9
- Q5JTL7
- Q5JTL8
- Q6NW13
- Q8WTU4
- Q95HL5
- Q95HL6
Protein attributes for RFX3 Gene
- Size:
- 749 amino acids
- Molecular mass:
- 83530 Da
- Quaternary structure:
-
- Heterodimer; heterodimerizes with RFX1 and RFX2, and RFX6.
Protein Expression for RFX3 Gene
Post-translational modifications for RFX3 Gene
Other Protein References for RFX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_016870490.1
- XP_011516300.1
- XP_016870489.1
- XP_006716903.1
- NP_002910.1
- XP_024303399.1
- XP_006716906.1
- XP_016870491.1
- XP_011516301.1
- XP_024303403.1
- XP_006716910.1
- NP_001269046.1
- NP_602304.1
- XP_024303398.1
- XP_006716907.1
- XP_024303402.1
- XP_011516303.1
- XP_024303401.1
- XP_006716908.1
- NP_001269045.1
- XP_024303400.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RFX3
- Novus Biologicals Antibodies for RFX3
-
Abcam antibodies for RFX3
- Invitrogen Antibodies for RFX3 (AFLGC-RFX3)
- GeneTex RFX3 Antibody for RFX3
-
Boster Bio Antibodies for RFX3
Protein Products
-
OriGene Purified Proteins for RFX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RFX3
- Origene Custom Protein Services for RFX3
- antibodies-online: Search results for 4 available RFX3 Proteins ranked by validation data
- Compare Top RFX3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for RFX3
-
Abcam proteins for RFX3
Assay Products
- antibodies-online: Search results for 1 available RFX3 Elisa Kits ranked by validation data
- Compare Top RFX3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RFX3 Gene
Domains & Families for RFX3 Gene
Gene Families for RFX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RFX3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RFX3 Gene
- GenScript: Design optimal peptide antigens:
-
- Regulatory factor X, 3 (Influences HLA class II expression) (B1ANP5_HUMAN)
- Regulatory factor X, 3 (Influences HLA class II expression) (B1ANP6_HUMAN)
- Regulatory factor X, 3 (Influences HLA class II expression) (B1ANP7_HUMAN)
- Regulatory factor X, 3 (Influences HLA class II expression) (Q5JTM0_HUMAN)
- Regulatory factor X, 3 (Influences HLA class II expression) (Q5JTM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48380- Family:
-
- Belongs to the RFX family.
Function for RFX3 Gene
Molecular function for RFX3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430).
- GENATLAS Biochemistry:
- transactivating DNA binding regulator 3,involved in MHC class II expression,binding the MHC promoter box X
Phenotypes From GWAS Catalog for RFX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003677 | DNA binding | TAS | 8600444 |
| GO:0003700 | DNA binding transcription factor activity | NAS | 8600444 |
| GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | TAS | 8289803 |
Phenotypes for RFX3 Gene
- MGI mutant phenotypes for RFX3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for RFX3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RFX3
-
CRISPR Products
-
OriGene CRISPR knockouts for RFX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RFX3
- genomics-online: gRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- Applied Biological Materials CRISPR for RFX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RFX3
- GenScript: Design CRISPR guide RNA sequences for RFX3
miRNA for RFX3 Gene
- miRTarBase miRNAs that target RFX3
-
- hsa-mir-335-5p (MIRT017663)
- hsa-mir-148b-3p (MIRT019371)
- hsa-mir-128-3p (MIRT021982)
- hsa-mir-615-3p (MIRT039992)
- hsa-mir-342-3p (MIRT043701)
- hsa-mir-4698 (MIRT441716)
- hsa-mir-892c-5p (MIRT441717)
- hsa-mir-4428 (MIRT441718)
- hsa-mir-3646 (MIRT441719)
- hsa-mir-3662 (MIRT441720)
- hsa-mir-1264 (MIRT654271)
- hsa-mir-4668-5p (MIRT666589)
- hsa-mir-6738-3p (MIRT666590)
- hsa-mir-544a (MIRT666591)
- hsa-mir-3977 (MIRT666592)
- hsa-mir-6071 (MIRT666593)
- hsa-mir-6828-3p (MIRT666594)
- hsa-mir-222-5p (MIRT666595)
Targeted motifs for RFX3 Gene
HOMER Transcription Factor Regulatory Elements motif RFX3
- Consensus sequence: CGGTTGCCATGGCAAC Submotif: canonical Cell Type: K562 GEO ID: SRA012198
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RFX3
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- genomics-online: shRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RFX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RFX3
- Applied Biological Materials Clones for RFX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RFX3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for RFX3 Gene
Localization for RFX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RFX3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| cytoskeleton | 1 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 20413507 |
| GO:0005634 | nucleus | TAS,IC | 12411430 |
| GO:0005667 | transcription factor complex | IC | 20413507 |
Pathways & Interactions for RFX3 Gene
No Data Available
Interacting Proteins for RFX3 Gene
Selected Interacting proteins:
P48380-RFX3_HUMAN
ENSP00000371434
for RFX3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RFX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003309 | type B pancreatic cell differentiation | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RFX3 Gene
Transcripts for RFX3 Gene
mRNA/cDNA for RFX3 Gene
- (21) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000382004 9307 bps (uc003zhr.5)
- ENST00000358730 2971 bps (uc033ckd.1)
- ENST00000449234 633 bps (uc064rxa.1)
- ENST00000458034 814 bps (uc064rxb.1)
- ENST00000457373 822 bps (uc064rxc.1)
Unigene Clusters for RFX3 Gene
- Regulatory factor X, 3 (influences HLA class II expression):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RFX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RFX3
- genomics-online: gRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- Applied Biological Materials CRISPR for RFX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RFX3
- GenScript: Design CRISPR guide RNA sequences for RFX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RFX3
- Browse OriGene Inhibitory RNA Products For RFX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RFX3
- genomics-online: shRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RFX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RFX3
- Applied Biological Materials Clones for RFX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RFX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Blymphocyte (30.8), Testis (16.6), Fetal Brain (12.3), and CD8 Tcells (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RFX3 Gene
NURSA nuclear receptor signaling pathways regulating expression of RFX3 Gene:
RFX3SOURCE GeneReport for Unigene cluster for RFX3 Gene:
Hs.136829Evidence on tissue expression from TISSUES for RFX3 Gene
- Nervous system(4.4)
- Muscle(4.2)
Primer Products
-
OriGene qPCR primer pairs for RFX3
-
OriGene qPCR primer pairs and template standards for RFX3
- genomics-online: primer clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFX3 Gene
Orthologs for RFX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RFX3 34 |
|
OneToOne | |
| LOC538070 33 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | RFX3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RFX3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RFX3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RFX3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rfx3 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | RFX3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RFX3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rfx3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rfx3 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003943 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rfx 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-19 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.4580 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4580 33 |
|
- Species where no ortholog for RFX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RFX3 Gene
- ENSEMBL:
- Gene Tree for RFX3 (if available)
- TreeFam:
- Gene Tree for RFX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RFX3: view image
Paralogs for RFX3 Gene
(3) SIMAP similar genes for RFX3 Gene using alignment to 9 proteins:
- RFX3_HUMAN
- A9Z1Z2_HUMAN
- F6UGA0_HUMAN
- F6USP3_HUMAN
- F6UV76_HUMAN
- F6XM74_HUMAN
- H0Y790_HUMAN
- H0Y7W5_HUMAN
- H0Y7Z4_HUMAN
Variants for RFX3 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006808 | -- | 3,428,113(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000010243 | -- | 3,221,010(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000035033 | -- | 3,254,534(-) | C/A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000035398 | -- | 3,526,635(-) | T/C | upstream_transcript_variant | |
| rs1000053327 | -- | 3,396,539(-) | C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1255308 | CNV | insertion | 17803354 |
| esv2477708 | CNV | deletion | 19546169 |
| esv2659402 | CNV | deletion | 23128226 |
| esv2762782 | CNV | loss | 21179565 |
| esv3331489 | CNV | insertion | 20981092 |
| esv3544440 | CNV | deletion | 23714750 |
| esv3619307 | CNV | loss | 21293372 |
| esv3619310 | CNV | loss | 21293372 |
| esv3619312 | CNV | loss | 21293372 |
| nsv1017474 | CNV | gain | 25217958 |
| nsv1077086 | CNV | deletion | 25765185 |
| nsv1136013 | CNV | deletion | 24896259 |
| nsv1148671 | CNV | deletion | 26484159 |
| nsv415859 | CNV | insertion | 16902084 |
| nsv416089 | CNV | insertion | 16902084 |
| nsv466091 | CNV | loss | 19166990 |
| nsv522711 | CNV | gain | 19592680 |
| nsv613145 | CNV | loss | 21841781 |
| nsv613146 | CNV | loss | 21841781 |
| nsv613147 | CNV | loss | 21841781 |
| nsv950831 | CNV | duplication | 24416366 |
| nsv956145 | CNV | deletion | 24416366 |
| nsv972292 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
5.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.92;
19.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RFX3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFX3 Gene
Disorders for RFX3 Gene
Additional Disease Information for RFX3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RFX3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFX3 Gene
Publications for RFX3 Gene
- RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. (PMID: 8289803) Reith W … Mach B (Molecular and cellular biology 1994) 2 3 4 58
- Rfx6 directs islet formation and insulin production in mice and humans. (PMID: 20148032) Smith SB … German MS (Nature 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for RFX3 Gene
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- Sino Biological Human cDNA Clone for RFX3
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RFX3
- Novus Biologicals proteins and lysates for RFX3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for RFX3
- Abcam proteins for RFX3
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Invitrogen Antibodies for RFX3 (AFLGC-RFX3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for RFX3
- antibodies-online: Search results for 47 available RFX3 Antibodies ranked by validation data
- Compare Top RFX3 Antibodies
- antibodies-online: Search results for 1 available RFX3 Elisa Kits ranked by validation data
- Compare Top RFX3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available RFX3 Proteins ranked by validation data
- Compare Top RFX3 Proteins
- Quality Products:
- GeneTex RFX3 Antibody for RFX3
- Search GeneTex for Proteins for RFX3
- Horizon Cell Lines for RFX3
- genomics-online: cdna clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- orf clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- genomics-online: gRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- genomics-online: primer clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- genomics-online: shRNA clones - Search results for 114 available RFX3 gene related products
- Overview of 114 available RFX3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RFX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RFX3
- GeneCopoeia miRNA 3'UTR Target clone products for RFX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RFX3
- Boster Bio Antibodies for RFX3
- Browse Boster Bio ELISA Kits
Sources for RFX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt