Aliases for RFPL4A Gene

Aliases for RFPL4A Gene

  • Ret Finger Protein Like 4A 2 3 5
  • RNF210 2 3 4
  • Ret Finger Protein-Like 4A 3 4
  • Ret Finger Protein-Like 4 2 3
  • RING Finger Protein 210 3 4
  • RFPL4 3 4
  • RFPL4A 5

External Ids for RFPL4A Gene

Previous HGNC Symbols for RFPL4A Gene

  • RFPL4

Previous GeneCards Identifiers for RFPL4A Gene

  • GC19P060963
  • GC19P056270
  • GC19P055759
  • GC19P055881

Summaries for RFPL4A Gene

GeneCards Summary for RFPL4A Gene

RFPL4A (Ret Finger Protein Like 4A) is a Protein Coding gene. Diseases associated with RFPL4A include Premature Menopause. An important paralog of this gene is RFPL4AL1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RFPL4A Gene

Genomics for RFPL4A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RFPL4A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055758 Enhancer 0.2 Ensembl 250.7 +1.1 1103 0.8 RFPL4A ZNF580 RFPL4AL1
GH19J055759 Enhancer 0.2 Ensembl 14.7 +2.3 2303 0.4 RFPL4A RFPL4AL1
GH19J055769 Enhancer 0.2 Ensembl 7.3 +12.5 12503 0.4 RFPL4AL1 RFPL4A RFPL4AP1 NLRP4
GH19J055768 Enhancer 0.2 Ensembl 0.4 +11.3 11303 0.4 RFPL4AL1 RFPL4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RFPL4A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RFPL4A

Top Transcription factor binding sites by QIAGEN in the RFPL4A gene promoter:
  • C/EBPbeta
  • CBF(2)
  • En-1
  • FOXD1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • NF-Y
  • Nkx2-5
  • Nkx6-1

Genomic Locations for RFPL4A Gene

Latest Assembly
6,124 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
4,035 bases
Plus strand

(GRCh37/hg19 by Ensembl)
4,162 bases
Plus strand

Genomic View for RFPL4A Gene

Genes around RFPL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFPL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFPL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFPL4A Gene

Proteins for RFPL4A Gene

  • Protein details for RFPL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ret finger protein-like 4A
    Protein Accession:

    Protein attributes for RFPL4A Gene

    287 amino acids
    Molecular mass:
    32238 Da
    Quaternary structure:
    • Interacts with PSMB1, UBE2A and CCNB1.

    Three dimensional structures from OCA and Proteopedia for RFPL4A Gene

neXtProt entry for RFPL4A Gene

Post-translational modifications for RFPL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RFPL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RFPL4A Gene

Domains & Families for RFPL4A Gene

Gene Families for RFPL4A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RFPL4A Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 210 (RFPLA_HUMAN)
genes like me logo Genes that share domains with RFPL4A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RFPL4A Gene

Function for RFPL4A Gene

Phenotypes From GWAS Catalog for RFPL4A Gene

Gene Ontology (GO) - Molecular Function for RFPL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RFPL4A: view
genes like me logo Genes that share phenotypes with RFPL4A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RFPL4A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RFPL4A Gene

Localization for RFPL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RFPL4A Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFPL4A gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RFPL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RFPL4A: view

Pathways & Interactions for RFPL4A Gene

PathCards logo

SuperPathways for RFPL4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RFPL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with RFPL4A: view

No data available for Pathways by source and SIGNOR curated interactions for RFPL4A Gene

Drugs & Compounds for RFPL4A Gene

No Compound Related Data Available

Transcripts for RFPL4A Gene

mRNA/cDNA for RFPL4A Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RFPL4A

Alternative Splicing Database (ASD) splice patterns (SP) for RFPL4A Gene

No ASD Table

Relevant External Links for RFPL4A Gene

GeneLoc Exon Structure for

Expression for RFPL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RFPL4A Gene

mRNA differential expression in normal tissues according to GTEx for RFPL4A Gene

This gene is overexpressed in Liver (x23.2) and Testis (x14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RFPL4A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RFPL4A

SOURCE GeneReport for Unigene cluster for RFPL4A Gene:


Evidence on tissue expression from TISSUES for RFPL4A Gene

  • Lung(4.9)
  • Nervous system(4.9)
  • Eye(4.9)
  • Skin(4.9)
  • Liver(4.9)
  • Pancreas(4.9)
  • Intestine(4.9)
  • Muscle(4.7)
  • Blood(4.6)
  • Bone(4.6)
  • Kidney(4.6)
  • Stomach(4.4)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with RFPL4A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFPL4A Gene

Orthologs for RFPL4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFPL4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 97 (a)
-- 30
  • 97 (a)
-- 30
  • 97 (a)
-- 30
  • 97 (a)
-- 30
  • 96 (a)
(Canis familiaris)
Mammalia -- 30
  • 61 (a)
(Mus musculus)
Mammalia Rfpl4 30
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 33 (a)
Species where no ortholog for RFPL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RFPL4A Gene

Gene Tree for RFPL4A (if available)
Gene Tree for RFPL4A (if available)
Evolutionary constrained regions (ECRs) for RFPL4A: view image
Alliance of Genome Resources:
Additional Orthologs for RFPL4A

Paralogs for RFPL4A Gene

(11) SIMAP similar genes for RFPL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RFPL4A: view

Variants for RFPL4A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RFPL4A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RFPL4A Gene

Variant ID Type Subtype PubMed ID
dgv1088e212 CNV gain 25503493
dgv1089e212 CNV loss 25503493
esv2432344 CNV deletion 19546169
esv24770 CNV loss 19812545
esv2664981 CNV deletion 23128226
esv2718988 CNV deletion 23290073
esv2758773 CNV gain 17122850
esv2760504 CNV gain 21179565
esv3329 CNV loss 18987735
esv3429690 CNV duplication 20981092
esv3575031 CNV gain 25503493
esv3575064 CNV gain 25503493
esv3583576 CNV loss 25503493
esv3583581 CNV loss 25503493
esv6309 CNV loss 19470904
nsv1057383 CNV gain 25217958
nsv1060269 CNV gain 25217958
nsv1060544 CNV gain 25217958
nsv1066324 CNV gain+loss 25217958
nsv1076471 CNV duplication 25765185
nsv1110331 CNV duplication 24896259
nsv1130739 CNV deletion 24896259
nsv1146361 CNV duplication 26484159
nsv2556 CNV insertion 18451855
nsv435699 CNV deletion 17901297
nsv442473 CNV gain 18776908
nsv482047 CNV gain 20164927
nsv509753 CNV insertion 20534489
nsv510927 OTHER complex 20534489
nsv514903 CNV gain 21397061
nsv580346 CNV gain 21841781
nsv580347 CNV gain 21841781
nsv821063 CNV duplication 20802225
nsv828645 CNV loss 20364138
nsv833882 CNV loss 17160897
nsv960876 CNV duplication 23825009
nsv9772 CNV loss 18304495

Variation tolerance for RFPL4A Gene

Gene Damage Index Score: 0.52; 11.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RFPL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RFPL4A Gene

Disorders for RFPL4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RFPL4A Gene - From: COP

Disorder Aliases PubMed IDs
premature menopause
  • menopause - premature
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RFPL4A

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RFPL4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RFPL4A Gene

Publications for RFPL4A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. (PMID: 16364311) Grütter C … Grütter MG (FEBS letters 2006) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. (PMID: 11850190) Rajkovic A … Matzuk MM (Mechanisms of development 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for RFPL4A Gene

Sources for RFPL4A Gene