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RFPL1 (Ret Finger Protein Like 1) is a Protein Coding gene. An important paralog of this gene is RFPL3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22J029401 | Enhancer | 0.5 | Ensembl | 250.7 | -1.3 | -1330 | 0.2 | SPI1 ATF2 ATF1 ATF3 CREB1 ATF7 | RFPL1 FJ601684-297 AP1B1 ENSG00000285697 L13304-023 | |
GH22J029403 | Enhancer | 0.2 | Ensembl | 250.7 | +0.7 | 670 | 0.2 | RFPL1 HSALNG0134828 ENSG00000285697 NEFH L13304-023 | ||
GH22J029479 | Promoter/Enhancer | 1.7 | EPDnew FANTOM5 Ensembl ENCODE | 11.8 | +78.4 | 78352 | 3.2 | TBP MNT IKZF1 MBD2 ZNF395 REST CTCF HCFC1 ZNF341 ZBTB33 | NEFH ENSG00000282816 LOC107985541 THOC5 RFPL1 RASL10A NIPSNAP1 RF00017-3793 L13304-023 | |
GH22J029470 | Enhancer | 0.9 | ENCODE | 12.6 | +67.6 | 67560 | 1.1 | ZBTB10 ETS1 ZNF217 CTCF ELF1 SIN3A REST TRIM22 SMAD4 SAP130 | RFPL1 THOC5 RFPL1S NIPSNAP1 piR-52788 NEFH LOC107985541 L13304-023 | |
GH22J029423 | Promoter/Enhancer | 0.6 | EPDnew Ensembl | 12.7 | +20.3 | 20270 | 0.6 | CBFA2T3 | ENSG00000242156 AP1B1 RFPL1 RFPL1S THOC5 RFPL4AP6 NEFH L13304-023 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IBA | 21873635 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IBA | 21873635 |
GO:0005737 | cytoplasm | IEA,IDA | 20725088 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IDA | 20725088 |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | IDA | 20725088 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | 20725088 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RFPL3 30 |
|
||
RFPL1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16987627 | - |
p.Trp94Arg |
|||
rs3804076 | - |
p.Met127Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1059994 | CNV | gain | 25217958 |
nsv1060197 | CNV | gain | 25217958 |
nsv1110864 | OTHER | inversion | 24896259 |
nsv964618 | CNV | duplication | 23825009 |
nsv979667 | CNV | duplication | 23825009 |
No disorders were found for RFPL1 Gene.