Aliases for RFNG Gene
- RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 2 3 5
- Beta-1,3-N-Acetylglucosaminyltransferase Radical Fringe 3 4
- O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 3 4
- EC 220.127.116.11 4 51
- Radical Fringe (Drosophila) Homolog 2
- Radical Fringe Homolog (Drosophila) 2
- Radical Fringe Homolog 3
- RFNG 5
External Ids for RFNG Gene
Previous GeneCards Identifiers for RFNG Gene
GeneCards Summary for RFNG Gene
RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with RFNG include Congenital Muscular Dystrophy-Dystroglycanopathy Type A11 and Dowling-Degos Disease. Among its related pathways are Signaling by GPCR and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.
UniProtKB/Swiss-Prot Summary for RFNG Gene
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.