Aliases for RFK Gene
External Ids for RFK Gene
Previous GeneCards Identifiers for RFK Gene
Riboflavin kinase (RFK; EC 184.108.40.206) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
GeneCards Summary for RFK Gene
RFK (Riboflavin Kinase) is a Protein Coding gene. Diseases associated with RFK include Riboflavin Deficiency. Among its related pathways are Selenium Micronutrient Network and Metabolism. Gene Ontology (GO) annotations related to this gene include riboflavin kinase activity.
UniProtKB/Swiss-Prot Summary for RFK Gene
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.