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Aliases for RFESD Gene

Aliases for RFESD Gene

  • Rieske Fe-S Domain Containing 2 3 5
  • Rieske (Fe-S) Domain Containing 2

External Ids for RFESD Gene

Previous GeneCards Identifiers for RFESD Gene

  • GC05P095009
  • GC05P094982
  • GC05P090172

Summaries for RFESD Gene

GeneCards Summary for RFESD Gene

RFESD (Rieske Fe-S Domain Containing) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 2 iron, 2 sulfur cluster binding.

Additional gene information for RFESD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RFESD Gene

Genomics for RFESD Gene

GeneHancer (GH) Regulatory Elements for RFESD Gene

Promoters and enhancers for RFESD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I095645 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.1 1070 4.9 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 RFESD SPATA9 RHOBTB3 ENSG00000250240 GPR150 LINC01554 LOC105379090
GH05I095643 Enhancer 1 Ensembl ENCODE 0.8 -2.3 -2256 1.2 HDAC1 ELF3 HDGF ZSCAN4 ZNF133 ARID4B ZNF2 RAD21 RFX5 YY1 RFESD GC05M095620
GH05I095619 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.3 -25.4 -25422 2.9 RING1 ELF3 CTCF TFAP4 MXI1 FOXA2 BACH1 MAX SIN3A EBF1 GPR150 GC05M095611 GC05M095620 SPATA9 RFESD
GH05I095640 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.4 -5.1 -5127 2.3 FOXA2 TAF1 MAX ZNF644 RAD21 YY1 TEAD3 GATA3 RXRA REST SPATA9 GPR150 LINC01554 RHOBTB3 ENSG00000250240 ENSG00000251409 GLRX LOC105379091 RFESD GC05M095620
GH05I095630 Enhancer 1 Ensembl ENCODE 0.4 -15.2 -15200 2.6 PKNOX1 MZF1 ZBTB40 TCF12 ZNF143 CREM THAP11 HCFC1 SMAD5 GTF2B SPATA9 RHOBTB3 ENSG00000251409 LINC01554 ENSG00000250240 GC05M095620 RFESD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RFESD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RFESD gene promoter:

Genomic Locations for RFESD Gene

Genomic Locations for RFESD Gene
38,033 bases
Plus strand

Genomic View for RFESD Gene

Genes around RFESD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RFESD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RFESD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RFESD Gene

Proteins for RFESD Gene

  • Protein details for RFESD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rieske domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • J3KPH1

    Protein attributes for RFESD Gene

    157 amino acids
    Molecular mass:
    17762 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RFESD Gene


neXtProt entry for RFESD Gene

Post-translational modifications for RFESD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RFESD Gene

Domains & Families for RFESD Gene

Gene Families for RFESD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RFESD Gene

Suggested Antigen Peptide Sequences for RFESD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RFESD: view

No data available for UniProtKB/Swiss-Prot for RFESD Gene

Function for RFESD Gene

Phenotypes From GWAS Catalog for RFESD Gene

Gene Ontology (GO) - Molecular Function for RFESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with RFESD: view
genes like me logo Genes that share phenotypes with RFESD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RFESD Gene

Localization for RFESD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RFESD gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RFESD Gene

Pathways & Interactions for RFESD Gene

SuperPathways for RFESD Gene

No Data Available

Interacting Proteins for RFESD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8TAC1-RFESD_HUMAN ENSP00000369341 for RFESD Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for RFESD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RFESD: view

No data available for Pathways by source and SIGNOR curated interactions for RFESD Gene

Drugs & Compounds for RFESD Gene

No Compound Related Data Available

Transcripts for RFESD Gene

Unigene Clusters for RFESD Gene

Rieske (Fe-S) domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RFESD Gene

No ASD Table

Relevant External Links for RFESD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RFESD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RFESD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RFESD Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for RFESD Gene

This gene is overexpressed in Fetal Liver (16.6), Cerebral cortex (12.8), Spleen (12.8), Skin (11.1), and Ovary (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RFESD Gene

NURSA nuclear receptor signaling pathways regulating expression of RFESD Gene:


SOURCE GeneReport for Unigene cluster for RFESD Gene:


Evidence on tissue expression from TISSUES for RFESD Gene

  • Pancreas(4.2)
  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with RFESD: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RFESD Gene

Orthologs for RFESD Gene

This gene was present in the common ancestor of chordates.

Orthologs for RFESD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RFESD 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia RFESD 33 34
  • 93.12 (n)
(Bos Taurus)
Mammalia RFESD 33 34
  • 91.03 (n)
(Mus musculus)
Mammalia Rfesd 33 16 34
  • 87.26 (n)
(Rattus norvegicus)
Mammalia Rfesd 33
  • 85.06 (n)
(Monodelphis domestica)
Mammalia RFESD 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia RFESD 34
  • 68 (a)
(Gallus gallus)
Aves RFESD 33 34
  • 64.86 (n)
(Anolis carolinensis)
Reptilia RFESD 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rfesd 33
  • 65.99 (n)
(Danio rerio)
Actinopterygii LOC559859 33
  • 61.87 (n)
RFESD (2 of 4) 34
  • 50 (a)
RFESD (4 of 4) 34
  • 38 (a)
rfesd 34
  • 35 (a)
RFESD (1 of 4) 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2103 34
  • 27 (a)
Species where no ortholog for RFESD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RFESD Gene

Gene Tree for RFESD (if available)
Gene Tree for RFESD (if available)

Paralogs for RFESD Gene Pseudogenes for RFESD Gene

genes like me logo Genes that share paralogs with RFESD: view

No data available for Paralogs for RFESD Gene

Variants for RFESD Gene

Sequence variations from dbSNP and Humsavar for RFESD Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000009269 -- 95,645,378(+) C/T upstream_transcript_variant
rs1000510938 -- 95,655,104(+) C/G intron_variant
rs1000616537 -- 95,653,531(+) T/C intron_variant
rs1000920590 -- 95,649,376(+) C/G intron_variant
rs1001157923 -- 95,646,668(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RFESD Gene

Variant ID Type Subtype PubMed ID
esv2659181 CNV deletion 23128226
esv3605834 CNV loss 21293372
nsv598955 CNV gain 21841781
nsv598960 CNV loss 21841781

Variation tolerance for RFESD Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RFESD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RFESD Gene

Disorders for RFESD Gene

Additional Disease Information for RFESD

No disorders were found for RFESD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RFESD Gene

Publications for RFESD Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58

Products for RFESD Gene

Sources for RFESD Gene

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