Aliases for RFC5 Gene
External Ids for RFC5 Gene
Previous GeneCards Identifiers for RFC5 Gene
This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
GeneCards Summary for RFC5 Gene
RFC5 (Replication Factor C Subunit 5) is a Protein Coding gene. Diseases associated with RFC5 include Ocular Melanoma. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include enzyme binding and DNA clamp loader activity. An important paralog of this gene is RFC4.
UniProtKB/Swiss-Prot Summary for RFC5 Gene
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.