Aliases for RFC3 Gene
External Ids for RFC3 Gene
Previous GeneCards Identifiers for RFC3 Gene
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for RFC3 Gene
RFC3 (Replication Factor C Subunit 3) is a Protein Coding gene. Diseases associated with RFC3 include Childhood Apraxia Of Speech. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include ATPase activity and DNA clamp loader activity. An important paralog of this gene is RFC5.
UniProtKB/Swiss-Prot Summary for RFC3 Gene
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.