Aliases for RFC1 Gene
- Replication Factor C Subunit 1 2 3 4 5
- RFC140 2 3 4
- Replication Factor C (Activator 1) 1, 145kDa 2 3
- Replication Factor C 140 KDa Subunit 3 4
- Replication Factor C Large Subunit 3 4
- Activator 1 140 KDa Subunit 3 4
- DNA-Binding Protein PO-GA 3 4
- Activator 1 Large Subunit 3 4
- Activator 1 Subunit 1 3 4
- RF-C 140 KDa Subunit 3 4
External Ids for RFC1 Gene
Previous GeneCards Identifiers for RFC1 Gene
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for RFC1 Gene
RFC1 (Replication Factor C Subunit 1) is a Protein Coding gene. Diseases associated with RFC1 include Cerebellar Ataxia, Neuropathy, And Vestibular Areflexia Syndrome and Hutchinson-Gilford Progeria Syndrome. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding.
UniProtKB/Swiss-Prot Summary for RFC1 Gene
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.
Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.