Aliases for REXO5 Gene

Aliases for REXO5 Gene

  • RNA Exonuclease 5 2 3 4 5
  • Exonuclease NEF-Sp 3 4
  • NEF-Sp 2 3
  • Putative RNA Exonuclease NEF-Sp 3
  • EC 3.1.-.- 4
  • REXO5 5

External Ids for REXO5 Gene

Summaries for REXO5 Gene

GeneCards Summary for REXO5 Gene

REXO5 (RNA Exonuclease 5) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. An important paralog of this gene is REXO1.

Gene Wiki entry for REXO5 Gene

Additional gene information for REXO5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REXO5 Gene

Genomics for REXO5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for REXO5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REXO5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REXO5

Genomic Locations for REXO5 Gene

Genomic Locations for REXO5 Gene
chr16:20,806,429-20,849,682
(GRCh38/hg38)
Size:
43,254 bases
Orientation:
Plus strand
chr16:20,817,751-20,860,990
(GRCh37/hg19)
Size:
43,240 bases
Orientation:
Plus strand

Genomic View for REXO5 Gene

Genes around REXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO5 Gene

Proteins for REXO5 Gene

  • Protein details for REXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IC2-REXO5_HUMAN
    Recommended name:
    RNA exonuclease 5
    Protein Accession:
    Q96IC2
    Secondary Accessions:
    • B2RB19
    • O60364
    • Q96MB1
    • Q9BXH9
    • Q9H0K2
    • Q9NSM2

    Protein attributes for REXO5 Gene

    Size:
    774 amino acids
    Molecular mass:
    86886 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC31668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REXO5 Gene

Post-translational modifications for REXO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for REXO5 Gene

Domains & Families for REXO5 Gene

Gene Families for REXO5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REXO5 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Exonuclease
  • Exonuclease, RNase T and DNA polymerase III
ProtoNet:
genes like me logo Genes that share domains with REXO5: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for REXO5 Gene

Function for REXO5 Gene

Enzyme Numbers (IUBMB) for REXO5 Gene

Phenotypes From GWAS Catalog for REXO5 Gene

Gene Ontology (GO) - Molecular Function for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with REXO5: view
genes like me logo Genes that share phenotypes with REXO5: view

miRNA for REXO5 Gene

miRTarBase miRNAs that target REXO5

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO5 Gene

Localization for REXO5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO5 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005730 nucleolus IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with REXO5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for REXO5 Gene

Pathways & Interactions for REXO5 Gene

PathCards logo

SuperPathways for REXO5 Gene

genes like me logo Genes that share pathways with REXO5: view

Pathways by source for REXO5 Gene

1 KEGG pathway for REXO5 Gene

Gene Ontology (GO) - Biological Process for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO5: view

No data available for SIGNOR curated interactions for REXO5 Gene

Drugs & Compounds for REXO5 Gene

No Compound Related Data Available

Transcripts for REXO5 Gene

mRNA/cDNA for REXO5 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO5 Gene

No ASD Table

Relevant External Links for REXO5 Gene

GeneLoc Exon Structure for
REXO5

Expression for REXO5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REXO5

Evidence on tissue expression from TISSUES for REXO5 Gene

  • Lung(4.1)
  • Nervous system(2.8)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO5 Gene

Orthologs for REXO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC453977 30
  • 99.27 (n)
-- 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC479820 30
  • 89.18 (n)
-- 31
  • 84 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MGC134577 30
  • 87.02 (n)
-- 31
  • 81 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Exnef 30
  • 79.69 (n)
Mouse
(Mus musculus)
Mammalia 2610020H08Rik 30 31
  • 73.35 (n)
OneToOne
Rexo5 17
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 53 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC427001 30
  • 59.21 (n)
-- 31
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100158551 30
  • 57.18 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:152968 31
  • 6 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG8368 31
  • 20 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C05C8.5 31
  • 21 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 31
  • 20 (a)
OneToMany
Species where no ortholog for REXO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for REXO5 Gene

ENSEMBL:
Gene Tree for REXO5 (if available)
TreeFam:
Gene Tree for REXO5 (if available)

Paralogs for REXO5 Gene

Paralogs for REXO5 Gene

genes like me logo Genes that share paralogs with REXO5: view

Variants for REXO5 Gene

Additional dbSNP identifiers (rs#s) for REXO5 Gene

Structural Variations from Database of Genomic Variants (DGV) for REXO5 Gene

Variant ID Type Subtype PubMed ID
esv3638158 CNV loss 21293372
nsv1050009 CNV loss 25217958
nsv436835 CNV insertion 17901297
nsv833165 CNV loss 17160897

Variation tolerance for REXO5 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REXO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REXO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REXO5 Gene

Disorders for REXO5 Gene

No disorders were found for REXO5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO5 Gene

Publications for REXO5 Gene

  1. Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease. (PMID: 28539487) Silva S … Pillai RS (RNA (New York, N.Y.) 2017) 2 3
  2. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. (PMID: 29045842) Gerstberger S … Tuschl T (Cell reports 2017) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4

Products for REXO5 Gene

Sources for REXO5 Gene