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Aliases for REXO5 Gene

Aliases for REXO5 Gene

  • RNA Exonuclease 5 2 3 3 5
  • Exonuclease NEF-Sp 3 4
  • Putative RNA Exonuclease NEF-Sp 3
  • EC 3.1.-.- 4
  • NEF-Sp 3

External Ids for REXO5 Gene

Summaries for REXO5 Gene

GeneCards Summary for REXO5 Gene

REXO5 (RNA Exonuclease 5) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

Gene Wiki entry for REXO5 Gene

Additional gene information for REXO5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO5 Gene

Genomics for REXO5 Gene

GeneHancer (GH) Regulatory Elements for REXO5 Gene

Promoters and enhancers for REXO5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J020804 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 310 3.6 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 REXO5 ERI2 SMG1P3 THUMPD1 NPIPB3 ACSM1 ACSM3 ENSG00000275908
GH16J021505 Enhancer 1.5 Ensembl ENCODE dbSUPER 20 +703.7 703720 9.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B NEUROD1 SIN3A PIR56760 PIR32900 PIR45912 REXO5 LOC646828 LOC342293 LOC105371129 MFSD13B SMG1P3 SMG1P1
GH16J021597 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +793.1 793138 4.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 METTL9 LOC101927814 IGSF6 NPIPB5 REXO5 NPIPB4 NPIPB3 THUMPD1 SMG1P3 MFSD13B
GH16J021517 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.9 +713.8 713800 4.7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SMG1P3 SLC7A5P2 THUMPD1 RRN3P1 NPIPB4 NPIPB3 NPIPB5 SMG1P1 POLR3E LOC646828
GH16J021500 Promoter/Enhancer 1.6 Ensembl ENCODE 10.8 +695.6 695567 3.6 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ENSG00000260635 SMG1P1 SMG1P4 SMG1P3 MOSMO THUMPD1 POLR3E REXO5 MFSD13B ENSG00000260306
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REXO5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for REXO5 Gene

Genomic Locations for REXO5 Gene
chr16:20,806,429-20,849,668
(GRCh38/hg38)
Size:
43,240 bases
Orientation:
Plus strand
chr16:20,817,751-20,860,990
(GRCh37/hg19)
Size:
43,240 bases
Orientation:
Plus strand

Genomic View for REXO5 Gene

Genes around REXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO5 Gene

Proteins for REXO5 Gene

  • Protein details for REXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IC2-REXO5_HUMAN
    Recommended name:
    RNA exonuclease 5
    Protein Accession:
    Q96IC2
    Secondary Accessions:
    • B2RB19
    • O60364
    • Q96MB1
    • Q9BXH9
    • Q9H0K2
    • Q9NSM2

    Protein attributes for REXO5 Gene

    Size:
    774 amino acids
    Molecular mass:
    86886 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC31668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REXO5 Gene

Post-translational modifications for REXO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for REXO5 Gene

Domains & Families for REXO5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REXO5: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for REXO5 Gene

Function for REXO5 Gene

Enzyme Numbers (IUBMB) for REXO5 Gene

Gene Ontology (GO) - Molecular Function for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with REXO5: view
genes like me logo Genes that share phenotypes with REXO5: view

Animal Model Products

miRNA for REXO5 Gene

miRTarBase miRNAs that target REXO5

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO5 Gene

Localization for REXO5 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with REXO5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for REXO5 Gene

Pathways & Interactions for REXO5 Gene

genes like me logo Genes that share pathways with REXO5: view

Pathways by source for REXO5 Gene

1 KEGG pathway for REXO5 Gene

Gene Ontology (GO) - Biological Process for REXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO5: view

No data available for SIGNOR curated interactions for REXO5 Gene

Drugs & Compounds for REXO5 Gene

No Compound Related Data Available

Transcripts for REXO5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for REXO5 Gene

No ASD Table

Relevant External Links for REXO5 Gene

GeneLoc Exon Structure for
REXO5
ECgene alternative splicing isoforms for
REXO5

Expression for REXO5 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO5 Gene

Orthologs for REXO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC453977 33
  • 99.27 (n)
-- 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479820 33
  • 89.18 (n)
-- 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC134577 33
  • 87.02 (n)
-- 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exnef 33
  • 79.69 (n)
mouse
(Mus musculus)
Mammalia 2610020H08Rik 34 33
  • 73.35 (n)
OneToOne
Rexo5 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC427001 33
  • 59.21 (n)
-- 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158551 33
  • 57.18 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:152968 34
  • 6 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8368 34
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05C8.5 34
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 34
  • 20 (a)
OneToMany
Species where no ortholog for REXO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO5 Gene

ENSEMBL:
Gene Tree for REXO5 (if available)
TreeFam:
Gene Tree for REXO5 (if available)

Paralogs for REXO5 Gene

No data available for Paralogs for REXO5 Gene

Variants for REXO5 Gene

Sequence variations from dbSNP and Humsavar for REXO5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000040819 -- 20,829,983(+) C/T intron_variant
rs1000122437 -- 20,814,607(+) G/C intron_variant
rs1000222682 -- 20,842,613(+) G/A intron_variant
rs1000234852 -- 20,822,468(+) A/T intron_variant
rs1000272691 -- 20,843,267(+) C/T intron_variant

Additional Variant Information for REXO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REXO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for REXO5 Gene

Disorders for REXO5 Gene

Additional Disease Information for REXO5

No disorders were found for REXO5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO5 Gene

Publications for REXO5 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for REXO5 Gene

Sources for REXO5 Gene

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