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Aliases for REXO4 Gene

Aliases for REXO4 Gene

  • REX4 Homolog, 3'-5' Exonuclease 2
  • REX4 Homolog, 3-5 Exonuclease 2 3 5
  • Exonuclease XPMC2 3 4
  • XPMC2H 3 4
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog (Xenopus Laevis) 2
  • REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) 2
  • Xenopus Prevents Mitotic Catastrophe 2 Homolog 3
  • Prevents Mitotic Catastrophe 2 Protein Homolog 4
  • Xenopus Prevents Mitotic Catatrophe 2 Homolog 2
  • XPMC2 Prevents Mitotic Catastrophe 2 Homolog 3
  • REX4, RNA Exonuclease 4 Homolog 3
  • RNA Exonuclease 4 3
  • EC 3.1.-.- 4
  • XPMC2 3
  • HPMC2 4
  • REX4 3
  • PMC2 4

External Ids for REXO4 Gene

Previous HGNC Symbols for REXO4 Gene

  • XPMC2H

Previous GeneCards Identifiers for REXO4 Gene

  • GC09M133301
  • GC09M135261
  • GC09M136271
  • GC09M105773

Summaries for REXO4 Gene

GeneCards Summary for REXO4 Gene

REXO4 (REX4 Homolog, 3'-5' Exonuclease) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ISG20L2.

Gene Wiki entry for REXO4 Gene

Additional gene information for REXO4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO4 Gene

Genomics for REXO4 Gene

GeneHancer (GH) Regulatory Elements for REXO4 Gene

Promoters and enhancers for REXO4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I133416 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.2 195 3.5 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 REXO4 SURF1 SURF6 MED22 RPL7A ENSG00000273473 GTF3C5 DDX31 BRD3OS ADAMTS13
GH09I133029 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18 +387.5 387465 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTF3C5 LOC105376306 SETX TTF1 MED22 DDX31 TSC1 GTF3C4 BRD3OS SPACA9
GH09I134162 Promoter/Enhancer 1.6 Ensembl ENCODE 21.2 -746.3 -746313 3.6 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GC09P134164 GC09M134165 RNU6ATAC WDR5 BRD3 LOC100130548 REXO4 SURF6 ENSG00000273249 MED22
GH09I133333 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 +82.9 82889 4.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SURF6 WDR5 LOC100130548 TSC1 SURF1 BRD3 GTF3C5 GTF3C4 DDX31 TTF1
GH09I133112 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 +289.2 289200 33.8 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 RALGDS GTF3C5 SETX RPL7A GBGT1 BRD3 EEF1A1P5 DDX31 SLC2A6 GTF3C4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REXO4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REXO4 gene promoter:

Genomic Locations for REXO4 Gene

Genomic Locations for REXO4 Gene
12,115 bases
Minus strand

Genomic View for REXO4 Gene

Genes around REXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO4 Gene

Proteins for REXO4 Gene

  • Protein details for REXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA exonuclease 4
    Protein Accession:
    Secondary Accessions:
    • B2RAT2
    • Q5T8S4
    • Q5T8S5
    • Q5T8S6
    • Q9GZW3

    Protein attributes for REXO4 Gene

    422 amino acids
    Molecular mass:
    46672 Da
    Quaternary structure:
    • Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.
    • Sequence=CAI12845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12847.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for REXO4 Gene


neXtProt entry for REXO4 Gene

Post-translational modifications for REXO4 Gene

No Post-translational modifications

Other Protein References for REXO4 Gene

No data available for DME Specific Peptides for REXO4 Gene

Domains & Families for REXO4 Gene

Gene Families for REXO4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REXO4 Gene

Suggested Antigen Peptide Sequences for REXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the REXO4 family.
  • Belongs to the REXO4 family.
genes like me logo Genes that share domains with REXO4: view

Function for REXO4 Gene

Enzyme Numbers (IUBMB) for REXO4 Gene

Phenotypes From GWAS Catalog for REXO4 Gene

Gene Ontology (GO) - Molecular Function for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity NAS 10908561
GO:0003723 RNA binding HDA,IDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0008408 3-5 exonuclease activity IEA --
genes like me logo Genes that share ontologies with REXO4: view
genes like me logo Genes that share phenotypes with REXO4: view

Animal Model Products

miRNA for REXO4 Gene

miRTarBase miRNAs that target REXO4

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO4 Gene

Localization for REXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 10908561
GO:0005730 nucleolus IDA,IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with REXO4: view

Pathways & Interactions for REXO4 Gene

SuperPathways for REXO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 10908561
GO:0006364 rRNA processing IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO4: view

No data available for Pathways by source and SIGNOR curated interactions for REXO4 Gene

Drugs & Compounds for REXO4 Gene

No Compound Related Data Available

Transcripts for REXO4 Gene

Unigene Clusters for REXO4 Gene

REX4, RNA exonuclease 4 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for REXO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REXO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REXO4 Gene

Protein differential expression in normal tissues from HIPED for REXO4 Gene

This gene is overexpressed in Lung (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of REXO4 Gene:


SOURCE GeneReport for Unigene cluster for REXO4 Gene:


Evidence on tissue expression from TISSUES for REXO4 Gene

  • Liver(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with REXO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO4 Gene

Orthologs for REXO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REXO4 33 34
  • 98.89 (n)
(Canis familiaris)
Mammalia REXO4 33 34
  • 80.2 (n)
(Rattus norvegicus)
Mammalia Rexo4 33
  • 76.86 (n)
(Mus musculus)
Mammalia Rexo4 33 16 34
  • 76.23 (n)
(Bos Taurus)
Mammalia REXO4 33 34
  • 74.26 (n)
(Monodelphis domestica)
Mammalia REXO4 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia REXO4 34
  • 43 (a)
(Gallus gallus)
Aves REXO4 33 34
  • 63.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo4 33
  • 60.16 (n)
Str.8400 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52582 33
(Danio rerio)
Actinopterygii si:ch73-209e20.4 33
  • 57.53 (n)
REXO4 34
  • 36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13999 33
fruit fly
(Drosophila melanogaster)
Insecta CG6833 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y17G7B.12 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 34 36
  • 28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4479 33
Species where no ortholog for REXO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO4 Gene

Gene Tree for REXO4 (if available)
Gene Tree for REXO4 (if available)

Paralogs for REXO4 Gene

Paralogs for REXO4 Gene

(1) SIMAP similar genes for REXO4 Gene using alignment to 1 proteins: Pseudogenes for REXO4 Gene

genes like me logo Genes that share paralogs with REXO4: view

Variants for REXO4 Gene

Sequence variations from dbSNP and Humsavar for REXO4 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000072422 -- 133,414,106(-) C/T intron_variant
rs1000486126 -- 133,408,399(-) C/A intron_variant
rs1000586973 -- 133,415,624(-) C/T intron_variant
rs1000673228 -- 133,410,743(-) C/T intron_variant
rs1000966775 -- 133,419,270(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for REXO4 Gene

Variant ID Type Subtype PubMed ID
nsv433408 CNV gain 18776910
nsv1125319 OTHER inversion 24896259
esv2739138 CNV deletion 23290073

Variation tolerance for REXO4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REXO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO4 Gene

Disorders for REXO4 Gene

Additional Disease Information for REXO4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for REXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO4 Gene

Publications for REXO4 Gene

  1. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. (PMID: 9325058) Kwiatkowska J … Kwiatkowski DJ (Genomics 1997) 2 3 4 22 58
  2. The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. (PMID: 21602889) Krishnamurthy N … Montano MM (Oncogene 2011) 2 3 58
  3. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PMID: 20098615) Wooten EC … Huggins GS (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for REXO4 Gene

Sources for REXO4 Gene

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