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This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process... See more...
Aliases for REXO2 Gene
Aliases for REXO2 Gene
External Ids for REXO2 Gene
- HGNC: 17851
- NCBI Entrez Gene: 25996
- Ensembl: ENSG00000076043
- OMIM®: 607149
- UniProtKB/Swiss-Prot: Q9Y3B8
Previous GeneCards Identifiers for REXO2 Gene
- GC11P113816
- GC11P114311
- GC11P110238
Summaries for REXO2 Gene
-
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
GeneCards Summary for REXO2 Gene
REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Diseases associated with REXO2 include Immunodeficiency 13 and Noonan Syndrome 1. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity.
UniProtKB/Swiss-Prot Summary for REXO2 Gene
-
3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.
Additional gene information for REXO2 Gene
- HGNC (17851)
- NCBI Entrez Gene (25996)
- Ensembl (ENSG00000076043)
- OMIM® (607149)
- UniProtKB/Swiss-Prot (Q9Y3B8)
- Open Targets Platform(ENSG00000076043)
- Search for REXO2 at DataMed
- Search for REXO2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REXO2 Gene
Genomics for REXO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for REXO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around REXO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REXO2
- Top Transcription factor binding sites by QIAGEN in the REXO2 gene promoter:
-
- AML1a
- AP-1
- c-Fos
- E47
- Hand1
- HNF-1
- HNF-1A
- Nkx2-5
- PPAR-alpha
Genomic Locations for REXO2 Gene
Latest Assembly
- chr11:114,439,435-114,450,279
- (GRCh38/hg38)
- Size:
- 10,845 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:114,310,189-114,321,001
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 10,813 bases
- Orientation:
- Plus strand
- chr11:114,310,108-114,321,001
- (GRCh37/hg19 by Ensembl)
- Size:
- 10,894 bases
- Orientation:
- Plus strand
Genomic View for REXO2 Gene
Genes around REXO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by HGNC
- 11q23.2 by Entrez Gene
- 11q23.2 by Ensembl
REXO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for REXO2 Gene
Proteins for REXO2 Gene
-
Protein details for REXO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3B8-ORN_HUMAN
- Recommended name:
- Oligoribonuclease, mitochondrial
- Protein Accession:
- Q9Y3B8
- B2R532
- Q32Q18
- Q53FT1
- Q6FIC6
- Q9UFY7
Protein attributes for REXO2 Gene
- Size:
- 237 amino acids
- Molecular mass:
- 26833 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Homotetramer.
- Miscellaneous:
-
- Depletion of REXO2 by RNA interference causes a strong morphological phenotype showing disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaired de novo mitochondrial protein synthesis.
Three dimensional structures from OCA and Proteopedia for REXO2 Gene
Protein Expression for REXO2 Gene
Post-translational modifications for REXO2 Gene
Other Protein References for REXO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences REXO2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for REXO2
- Novus Biologicals Antibodies for REXO2
-
Abcam antibodies for REXO2
- Invitrogen Antibodies for REXO2 (AFLGC-REXO2)
-
Biorbyt antibodies for REXO2
-
Boster Bio Antibodies for REXO2
-
Custom Antibody ServicesProSci Antibodies for REXO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for REXO2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for REXO2
- Origene Custom Protein Services for REXO2
- ProSpec Recombinant Proteins for REXO2
- antibodies-online: Show 11 available REXO2 Proteins ranked by validation data
- Compare Top REXO2 Proteins
-
Quality Products:
-
Abcam proteins for REXO2
Assay products for research
No data available for DME Specific Peptides for REXO2 Gene
Domains & Families for REXO2 Gene
Gene Families for REXO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for REXO2 Gene
- InterPro:
- Blocks:
-
- Exonuclease
- Exonuclease, RNase T and DNA polymerase III
- ProtoNet:
Suggested Antigen Peptide Sequences for REXO2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92319, highly similar to Homo sapiens REX2, RNA exonuclease 2 homolog (S. cerevisiae) (REXO2), mRNA (B2R532_HUMAN)
- Small fragment nuclease (ORN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y3B8- Family:
-
- Belongs to the oligoribonuclease family.
Function for REXO2 Gene
Molecular function for REXO2 Gene
- UniProtKB/Swiss-Prot Function:
- 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by adenosine 3',5'-bisphosphate.
Enzyme Numbers (IUBMB) for REXO2 Gene
Phenotypes From GWAS Catalog for REXO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000175 | 3'-5'-exoribonuclease activity | IEA,IBA | 21873635 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004527 | exonuclease activity | IEA | -- |
| GO:0008408 | 3'-5' exonuclease activity | IDA | 10851236 |
Phenotypes for REXO2 Gene
- MGI mutant phenotypes for REXO2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for REXO2:
Animal Models for REXO2 Gene
- MGI Knock Outs for REXO2:
-
- Rexo2 Rexo2<tm1b(EUCOMM)Wtsi>
Animal Models for research
-
Taconic Biosciences Mouse Models for REXO2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for REXO2 - Starting at $85 >
- * REXO2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
miRNA for REXO2 Gene
- miRTarBase miRNAs that target REXO2
-
- hsa-miR-1229-3p (MIRT036305)
- hsa-miR-92b-3p (MIRT040651)
- hsa-miR-30c-5p (MIRT047931)
- hsa-miR-218-5p (MIRT439782)
- hsa-miR-3175 (MIRT488970)
- hsa-miR-6878-5p (MIRT488971)
- hsa-miR-31-5p (MIRT488972)
- hsa-miR-650 (MIRT488973)
- hsa-miR-5703 (MIRT488974)
- hsa-miR-3612 (MIRT488975)
- hsa-miR-4516 (MIRT488976)
- hsa-miR-4434 (MIRT488977)
- hsa-miR-6133 (MIRT488978)
- hsa-miR-6130 (MIRT488979)
- hsa-miR-6129 (MIRT488980)
- hsa-miR-6127 (MIRT488981)
- hsa-miR-4510 (MIRT488982)
- hsa-miR-4756-5p (MIRT488983)
- hsa-miR-4419a (MIRT488984)
- hsa-miR-4739 (MIRT488985)
- hsa-miR-1321 (MIRT488986)
- hsa-miR-4779 (MIRT488987)
- hsa-miR-562 (MIRT488988)
- hsa-miR-362-3p (MIRT542098)
- hsa-miR-8485 (MIRT542099)
- hsa-miR-329-3p (MIRT542100)
- hsa-miR-4634 (MIRT608388)
- hsa-miR-6858-3p (MIRT608919)
- hsa-miR-6720-5p (MIRT608920)
- hsa-miR-6512-3p (MIRT608921)
- hsa-miR-210-5p (MIRT608922)
- hsa-miR-4252 (MIRT608923)
- hsa-miR-3925-3p (MIRT608924)
- hsa-miR-766-3p (MIRT608925)
- hsa-miR-6727-3p (MIRT608926)
- hsa-miR-4722-3p (MIRT608927)
- hsa-miR-6752-3p (MIRT608928)
- hsa-miR-6810-3p (MIRT608929)
- hsa-miR-6801-3p (MIRT608930)
- hsa-miR-6849-3p (MIRT608931)
- hsa-miR-6760-3p (MIRT608932)
- hsa-miR-6769a-3p (MIRT608933)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REXO2
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Clone products for research
- Applied Biological Materials (abm): Clones for REXO2 - Starting at $45 >
- * REXO2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
Cell Lines for research
-
Horizon Cell Lines for REXO2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for REXO2 Gene
Localization for REXO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for REXO2 Gene
- [Isoform 1]: Mitochondrion intermembrane space. Mitochondrion matrix.
- [Isoform 2]: Nucleus.
- [Isoform 3]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Mitochondria (3)
- Focal adhesion sites (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005758 | mitochondrial intermembrane space | IEA | -- |
Pathways & Interactions for REXO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes | ||
Pathways by source for REXO2 Gene
1 KEGG pathway for REXO2 Gene
Interacting Proteins for REXO2 Gene
GPS-Prot Interaction Network for REXO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | IDA | 10851236 |
| GO:0009117 | nucleotide metabolic process | TAS | 10851236 |
| GO:0090305 | nucleic acid phosphodiester bond hydrolysis | IEA | -- |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IEA | -- |
No data available for SIGNOR curated interactions for REXO2 Gene
Drugs & Compounds for REXO2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | 64 |
Transcripts for REXO2 Gene
mRNA/cDNA for REXO2 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000265881 1080 nts (view in UCSC)
- ENST00000538198 449 nts (view in UCSC)
- ENST00000538403 753 nts (view in UCSC)
- ENST00000538791 1081 nts (view in UCSC)
- ENST00000539119 664 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for REXO2 - Starting at $85 >
- * REXO2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REXO2
- Browse OriGene Inhibitory RNA Products For REXO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REXO2
Clone products for research
- Applied Biological Materials (abm): Clones for REXO2 - Starting at $45 >
- * REXO2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for REXO2 Gene
- GeneLoc Exon Structure for
- REXO2
Expression for REXO2 Gene
This gene is overexpressed in Skin (8.1), Uterus (7.7), and Peripheral blood mononuclear cells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for REXO2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REXO2
SOURCE GeneReport for Unigene cluster for REXO2 Gene:
Hs.677190Evidence on tissue expression from TISSUES for REXO2 Gene
- Nervous system(4.7)
- Muscle(4.5)
- Kidney(4.5)
- Liver(4.3)
- Pancreas(2.6)
- Skin(2.4)
- Heart(2.3)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for REXO2
-
OriGene qPCR primer pairs and template standards for REXO2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO2 Gene
Orthologs for REXO2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rexo2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rexo2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | REXO2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | REXO2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | REXO2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | REXO2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rexo2 30 |
|
||
| Str.1796 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9259 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | smfn 30 31 |
|
OneToOne | |
| zgc73191 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12624 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012804 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10214 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_C08B6.8 30 |
|
||
| C08B6.8 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REX2 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F08998g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR217C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G26970 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0465500 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.5073 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rex2 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15100 30 |
|
- Species where no ortholog for REXO2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for REXO2 Gene
- ENSEMBL:
- Gene Tree for REXO2 (if available)
- TreeFam:
- Gene Tree for REXO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for REXO2: view image
Paralogs for REXO2 Gene
No data available for Paralogs for REXO2 Gene
Variants for REXO2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.75;
15.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for REXO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- REXO2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for REXO2 Gene
Disorders for REXO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 13 |
|
|
| noonan syndrome 1 |
|
|
Search REXO2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for REXO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for REXO2 Gene
Publications for REXO2 Gene
- The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. (PMID: 10851236) Nguyen LH … Wilson DM (The Journal of biological chemistry 2000) 2 3 4 23
- REXO2 is an oligoribonuclease active in human mitochondria. (PMID: 23741365) Bruni F … Chrzanowska-Lightowlers ZM (PloS one 2013) 2 3 4
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PMID: 16682444) Mechold U … Danchin A (Nucleic acids research 2006) 4 23
ExternalLinks
Products for REXO2 Gene
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- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for REXO2
- Abcam proteins for REXO2
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- ProSpec Recombinant Proteins for REXO2
- Taconic Biosciences Mouse Models for REXO2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for REXO2 (AFLGC-REXO2)
- VectorBuilder Custom and pre-made DNA vectors for REXO2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for REXO2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for REXO2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for REXO2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for REXO2
- antibodies-online: Show 18 available REXO2 Antibodies ranked by validation data
- Compare Top REXO2 Antibodies
- antibodies-online: Search results for available REXO2 related products ranked by validation data
- antibodies-online: Show 11 available REXO2 Proteins ranked by validation data
- Compare Top REXO2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for REXO2
- Search Santa Cruz Biotechnology (SCBT) for REXO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
- Horizon Cell Lines for REXO2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for REXO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REXO2
- Boster Bio Antibodies for REXO2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for REXO2
Sources for REXO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB