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This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Diseases associated with REXO2 include Immunodeficiency 13 and Noonan Syndrome 1. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000175 | 3'-5'-exoribonuclease activity | IEA,IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0004518 | nuclease activity | IEA | -- |
GO:0004527 | exonuclease activity | IEA | -- |
GO:0008408 | 3'-5' exonuclease activity | IDA | 10851236 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IDA | -- |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ribosome biogenesis in eukaryotes |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006139 | nucleobase-containing compound metabolic process | IDA | 10851236 |
GO:0009117 | nucleotide metabolic process | TAS | 10851236 |
GO:0090305 | nucleic acid phosphodiester bond hydrolysis | IEA | -- |
GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Manganese | Approved | Nutra | 64 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP10: | - | - | |||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rexo2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rexo2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | REXO2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | REXO2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | REXO2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | REXO2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rexo2 30 |
|
||
Str.1796 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.9259 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | smfn 30 31 |
|
OneToOne | |
zgc73191 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12624 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012804 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10214 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_C08B6.8 30 |
|
||
C08B6.8 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REX2 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F08998g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR217C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G26970 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0465500 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.5073 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rex2 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15100 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 13 |
|
|
noonan syndrome 1 |
|
|