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This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Diseases associated with REXO2 include Lennox-Gastaut Syndrome and Noonan Syndrome 1. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000175 | 3'-5'-exoribonuclease activity | IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0004518 | nuclease activity | IEA | -- |
GO:0004527 | exonuclease activity | IEA | -- |
GO:0008408 | 3'-5' exonuclease activity | IDA | 10851236 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IBA,IDA | -- |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ribosome biogenesis in eukaryotes |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006139 | nucleobase-containing compound metabolic process | IDA | 10851236 |
GO:0009117 | nucleotide metabolic process | TAS | 10851236 |
GO:0090305 | nucleic acid phosphodiester bond hydrolysis | IEA | -- |
GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Manganese | Approved | Nutra | 56 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP10: | - | - | |||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rexo2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rexo2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | REXO2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | REXO2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | REXO2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | REXO2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rexo2 30 |
|
||
Str.1796 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.9259 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | smfn 30 31 |
|
OneToOne | |
zgc73191 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12624 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012804 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10214 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_C08B6.8 30 |
|
||
C08B6.8 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REX2 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F08998g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR217C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G26970 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0465500 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.5073 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rex2 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15100 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
lennox-gastaut syndrome |
|
|
noonan syndrome 1 |
|
|