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This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process... See more...
Aliases for REXO2 Gene
Aliases for REXO2 Gene
External Ids for REXO2 Gene
- HGNC: 17851
- Entrez Gene: 25996
- Ensembl: ENSG00000076043
- OMIM: 607149
- UniProtKB: Q9Y3B8
Previous GeneCards Identifiers for REXO2 Gene
- GC11P113816
- GC11P114311
- GC11P110238
Summaries for REXO2 Gene
-
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
GeneCards Summary for REXO2 Gene
REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Diseases associated with REXO2 include Lennox-Gastaut Syndrome and Noonan Syndrome 1. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity.
UniProtKB/Swiss-Prot Summary for REXO2 Gene
-
3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.
Additional gene information for REXO2 Gene
- HGNC(17851)
- Entrez Gene(25996)
- Ensembl(ENSG00000076043)
- OMIM(607149)
- UniProtKB(Q9Y3B8)
- Open Targets Platform(ENSG00000076043)
- Search for REXO2 at DataMed
- Search for REXO2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REXO2 Gene
Genomics for REXO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for REXO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around REXO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REXO2
- Top Transcription factor binding sites by QIAGEN in the REXO2 gene promoter:
-
- AML1a
- AP-1
- c-Fos
- E47
- Hand1
- HNF-1
- HNF-1A
- Nkx2-5
- PPAR-alpha
Genomic Locations for REXO2 Gene
Genomic Locations for REXO2 Gene
- chr11:114,439,386-114,450,279
- (GRCh38/hg38)
- Size:
- 10,894 bases
- Orientation:
- Plus strand
- chr11:114,310,108-114,321,001
- (GRCh37/hg19)
- Size:
- 10,894 bases
- Orientation:
- Plus strand
Genomic View for REXO2 Gene
Genes around REXO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by HGNC
- 11q23.2 by Entrez Gene
- 11q23.2 by Ensembl
REXO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for REXO2 Gene
Proteins for REXO2 Gene
-
Protein details for REXO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3B8-ORN_HUMAN
- Recommended name:
- Oligoribonuclease, mitochondrial
- Protein Accession:
- Q9Y3B8
- B2R532
- Q32Q18
- Q53FT1
- Q6FIC6
- Q9UFY7
Protein attributes for REXO2 Gene
- Size:
- 237 amino acids
- Molecular mass:
- 26833 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Homotetramer.
- Miscellaneous:
-
- Depletion of REXO2 by RNA interference causes a strong morphological phenotype showing disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaired de novo mitochondrial protein synthesis.
Three dimensional structures from OCA and Proteopedia for REXO2 Gene
Protein Expression for REXO2 Gene
Post-translational modifications for REXO2 Gene
Other Protein References for REXO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences REXO2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for REXO2
- Novus Biologicals Antibodies for REXO2
-
Abcam antibodies for REXO2
- Invitrogen Antibodies for REXO2 (AFLGC-REXO2)
-
Biorbyt antibodies for REXO2
-
Boster Bio Antibodies for REXO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for REXO2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for REXO2
- Origene Custom Protein Services for REXO2
- ProSpec Recombinant Proteins for REXO2
- antibodies-online: Show 11 available REXO2 Proteins ranked by validation data
- Compare Top REXO2 Proteins
-
Quality Products:
-
Abcam proteins for REXO2
No data available for DME Specific Peptides for REXO2 Gene
Domains & Families for REXO2 Gene
Gene Families for REXO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for REXO2 Gene
- InterPro:
- Blocks:
-
- Exonuclease
- Exonuclease, RNase T and DNA polymerase III
- ProtoNet:
Suggested Antigen Peptide Sequences for REXO2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92319, highly similar to Homo sapiens REX2, RNA exonuclease 2 homolog (S. cerevisiae) (REXO2), mRNA (B2R532_HUMAN)
- Small fragment nuclease (ORN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y3B8- Family:
-
- Belongs to the oligoribonuclease family.
Function for REXO2 Gene
Molecular function for REXO2 Gene
- UniProtKB/Swiss-Prot Function:
- 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by adenosine 3',5'-bisphosphate.
Enzyme Numbers (IUBMB) for REXO2 Gene
Phenotypes From GWAS Catalog for REXO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000175 | 3'-5'-exoribonuclease activity | IBA | 21873635 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004527 | exonuclease activity | IEA | -- |
| GO:0008408 | 3'-5' exonuclease activity | IDA | 10851236 |
Phenotypes for REXO2 Gene
- MGI mutant phenotypes for REXO2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for REXO2:
Animal Models for REXO2 Gene
- MGI Knock Outs for REXO2:
-
- Rexo2 Rexo2<tm1b(EUCOMM)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for REXO2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for REXO2 - Select products 50% OFF >
- * REXO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
miRNA for REXO2 Gene
- miRTarBase miRNAs that target REXO2
-
- hsa-miR-1229-3p (MIRT036305)
- hsa-miR-92b-3p (MIRT040651)
- hsa-miR-30c-5p (MIRT047931)
- hsa-miR-218-5p (MIRT439782)
- hsa-miR-3175 (MIRT488970)
- hsa-miR-6878-5p (MIRT488971)
- hsa-miR-31-5p (MIRT488972)
- hsa-miR-650 (MIRT488973)
- hsa-miR-5703 (MIRT488974)
- hsa-miR-3612 (MIRT488975)
- hsa-miR-4516 (MIRT488976)
- hsa-miR-4434 (MIRT488977)
- hsa-miR-6133 (MIRT488978)
- hsa-miR-6130 (MIRT488979)
- hsa-miR-6129 (MIRT488980)
- hsa-miR-6127 (MIRT488981)
- hsa-miR-4510 (MIRT488982)
- hsa-miR-4756-5p (MIRT488983)
- hsa-miR-4419a (MIRT488984)
- hsa-miR-4739 (MIRT488985)
- hsa-miR-1321 (MIRT488986)
- hsa-miR-4779 (MIRT488987)
- hsa-miR-562 (MIRT488988)
- hsa-miR-362-3p (MIRT542098)
- hsa-miR-8485 (MIRT542099)
- hsa-miR-329-3p (MIRT542100)
- hsa-miR-4634 (MIRT608388)
- hsa-miR-6858-3p (MIRT608919)
- hsa-miR-6720-5p (MIRT608920)
- hsa-miR-6512-3p (MIRT608921)
- hsa-miR-210-5p (MIRT608922)
- hsa-miR-4252 (MIRT608923)
- hsa-miR-3925-3p (MIRT608924)
- hsa-miR-766-3p (MIRT608925)
- hsa-miR-6727-3p (MIRT608926)
- hsa-miR-4722-3p (MIRT608927)
- hsa-miR-6752-3p (MIRT608928)
- hsa-miR-6810-3p (MIRT608929)
- hsa-miR-6801-3p (MIRT608930)
- hsa-miR-6849-3p (MIRT608931)
- hsa-miR-6760-3p (MIRT608932)
- hsa-miR-6769a-3p (MIRT608933)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REXO2
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Clone Products
- Applied Biological Materials (abm): Clones for REXO2 - Select products 50% OFF >
- * REXO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
Cell Line Products
-
Horizon Cell Lines for REXO2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for REXO2 Gene
Localization for REXO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for REXO2 Gene
- [Isoform 1]: Mitochondrion intermembrane space. Mitochondrion matrix.
- [Isoform 2]: Nucleus.
- [Isoform 3]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Mitochondria (3)
- Focal adhesion sites (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IBA,IDA | -- |
| GO:0005758 | mitochondrial intermembrane space | IEA | -- |
Pathways & Interactions for REXO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes | ||
Pathways by source for REXO2 Gene
1 KEGG pathway for REXO2 Gene
Interacting Proteins for REXO2 Gene
GPS-Prot Interaction Network for REXO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | IDA | 10851236 |
| GO:0009117 | nucleotide metabolic process | TAS | 10851236 |
| GO:0090305 | nucleic acid phosphodiester bond hydrolysis | IEA | -- |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IEA | -- |
No data available for SIGNOR curated interactions for REXO2 Gene
Drugs & Compounds for REXO2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | 56 |
Transcripts for REXO2 Gene
mRNA/cDNA for REXO2 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000265881 1080 nts (view in UCSC)
- ENST00000538198 449 nts (view in UCSC)
- ENST00000538403 753 nts (view in UCSC)
- ENST00000538791 1081 nts (view in UCSC)
- ENST00000539119 664 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for REXO2 - Select products 50% OFF >
- * REXO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REXO2
- Browse OriGene Inhibitory RNA Products For REXO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REXO2
Clone Products
- Applied Biological Materials (abm): Clones for REXO2 - Select products 50% OFF >
- * REXO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for REXO2 Gene
- GeneLoc Exon Structure for
- REXO2
Expression for REXO2 Gene
This gene is overexpressed in Skin (8.1), Uterus (7.7), and Peripheral blood mononuclear cells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for REXO2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REXO2
SOURCE GeneReport for Unigene cluster for REXO2 Gene:
Hs.677190Evidence on tissue expression from TISSUES for REXO2 Gene
- Nervous system(4.7)
- Muscle(4.6)
- Kidney(4.5)
- Liver(4.4)
- Skin(2.7)
- Pancreas(2.6)
- Heart(2.6)
- Lung(2.2)
- Bone marrow(2.1)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for REXO2
-
OriGene qPCR primer pairs and template standards for REXO2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO2 Gene
Orthologs for REXO2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | REXO2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rexo2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rexo2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | REXO2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | REXO2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | REXO2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | REXO2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rexo2 30 |
|
||
| Str.1796 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9259 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | smfn 30 31 |
|
OneToOne | |
| zgc73191 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12624 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012804 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10214 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_C08B6.8 30 |
|
||
| C08B6.8 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REX2 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F08998g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR217C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G26970 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0465500 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.5073 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rex2 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.15100 30 |
|
- Species where no ortholog for REXO2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for REXO2 Gene
- ENSEMBL:
- Gene Tree for REXO2 (if available)
- TreeFam:
- Gene Tree for REXO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for REXO2: view image
Paralogs for REXO2 Gene
No data available for Paralogs for REXO2 Gene
Variants for REXO2 Gene
Residual Variation Intolerance Score:
60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.75;
15.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for REXO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- REXO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for REXO2 Gene
Disorders for REXO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lennox-gastaut syndrome |
|
|
| noonan syndrome 1 |
|
|
Search REXO2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for REXO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for REXO2 Gene
Publications for REXO2 Gene
- The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. (PMID: 10851236) Nguyen LH … Wilson DM (The Journal of biological chemistry 2000) 2 3 4 23
- REXO2 is an oligoribonuclease active in human mitochondria. (PMID: 23741365) Bruni F … Chrzanowska-Lightowlers ZM (PloS one 2013) 2 3 4
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
- Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PMID: 16682444) Mechold U … Danchin A (Nucleic acids research 2006) 4 23
ExternalLinks
Products for REXO2 Gene
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for REXO2
- Taconic Biosciences Mouse Models for REXO2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for REXO2 (AFLGC-REXO2)
- VectorBuilder Custom and pre-made DNA vectors for REXO2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for REXO2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for REXO2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for REXO2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for REXO2
- antibodies-online: Show 18 available REXO2 Antibodies ranked by validation data
- Compare Top REXO2 Antibodies
- antibodies-online: Search results for available REXO2 related products ranked by validation data
- antibodies-online: Show 11 available REXO2 Proteins ranked by validation data
- Compare Top REXO2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for REXO2
- Search Santa Cruz Biotechnology (SCBT) for REXO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for REXO2
- Horizon Cell Lines for REXO2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REXO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REXO2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for REXO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REXO2
- Boster Bio Antibodies for REXO2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for REXO2
Sources for REXO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB