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Aliases for REXO2 Gene

Aliases for REXO2 Gene

  • RNA Exonuclease 2 2 3 5
  • RNA Exonuclease 2 Homolog 3 4
  • Small Fragment Nuclease 3 4
  • SFN 3 4
  • REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae) 2
  • Oligoribonuclease, Mitochondrial 3
  • REX2, RNA Exonuclease 2 Homolog 3
  • EC 3.1.-.- 4
  • CGI-114 3
  • REX2 3
  • SMFN 4
  • RFN 3

External Ids for REXO2 Gene

Previous GeneCards Identifiers for REXO2 Gene

  • GC11P113816
  • GC11P114311
  • GC11P110238

Summaries for REXO2 Gene

Entrez Gene Summary for REXO2 Gene

  • This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

GeneCards Summary for REXO2 Gene

REXO2 (RNA Exonuclease 2) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity.

UniProtKB/Swiss-Prot for REXO2 Gene

  • 3-to-5 exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.

Gene Wiki entry for REXO2 Gene

Additional gene information for REXO2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO2 Gene

Genomics for REXO2 Gene

GeneHancer (GH) Regulatory Elements for REXO2 Gene

Promoters and enhancers for REXO2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I114437 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 530 4.3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 FOS REXO2 LOC100422382 ENSG00000255663
GH11I114348 Enhancer 0.8 Ensembl ENCODE 12.1 -90.6 -90570 1.5 SMARCE1 CTCF ZNF654 REST RAD21 FOS PRDM10 TCF7L2 REXO2 LOC101928940 C11orf71 ENSG00000255663 RBM7 ENSG00000256947 GC11P114340
GH11I114416 Enhancer 0.3 ENCODE 11.9 -22.8 -22792 1 FOXA2 REXO2 RBM7 ENSG00000255663
GH11I114346 Enhancer 0.4 Ensembl 4.9 -92.5 -92485 0.6 IRF2 ZNF512 MNT C11orf71 ENSG00000255663 RBM7 LOC101928940 REXO2 ENSG00000256947 GC11P114340
GH11I114447 Enhancer 0.7 ENCODE 0.4 +8.7 8716 1.8 GTF2E2 CEBPG ZNF644 ZBTB40 TRIM24 NR4A1 CEBPB HDAC8 EP300 PRDM6 C11orf71 ENSG00000255663 RBM7 LOC101928940 LOC100422382 REXO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REXO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REXO2 gene promoter:

Genomic Locations for REXO2 Gene

Genomic Locations for REXO2 Gene
10,894 bases
Plus strand

Genomic View for REXO2 Gene

Genes around REXO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO2 Gene

Proteins for REXO2 Gene

  • Protein details for REXO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oligoribonuclease, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R532
    • Q32Q18
    • Q53FT1
    • Q6FIC6
    • Q9UFY7

    Protein attributes for REXO2 Gene

    237 amino acids
    Molecular mass:
    26833 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotetramer.
    • Depletion of REXO2 by RNA interference causes a strong morphological phenotype showing disorganized network of punctate and granular mitochondria. Lack of REXO2 protein also causes a substantial decrease of mitochondrial nucleic acid content and impaired de novo mitochondrial protein synthesis.

    Alternative splice isoforms for REXO2 Gene


neXtProt entry for REXO2 Gene

Post-translational modifications for REXO2 Gene

No data available for DME Specific Peptides for REXO2 Gene

Domains & Families for REXO2 Gene

Gene Families for REXO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the oligoribonuclease family.
  • Belongs to the oligoribonuclease family.
genes like me logo Genes that share domains with REXO2: view

Function for REXO2 Gene

Molecular function for REXO2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by adenosine 3,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
3-to-5 exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.

Enzyme Numbers (IUBMB) for REXO2 Gene

Gene Ontology (GO) - Molecular Function for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0008408 3-5 exonuclease activity IDA 10851236
genes like me logo Genes that share ontologies with REXO2: view

Phenotypes for REXO2 Gene

genes like me logo Genes that share phenotypes with REXO2: view

Animal Models for REXO2 Gene

MGI Knock Outs for REXO2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for REXO2 Gene

Localization for REXO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO2 Gene

Isoform 1: Mitochondrion intermembrane space. Mitochondrion matrix.
Isoform 2: Nucleus.
Isoform 3: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Focal adhesion sites (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA,IDA --
GO:0005758 mitochondrial intermembrane space IEA --
genes like me logo Genes that share ontologies with REXO2: view

Pathways & Interactions for REXO2 Gene

genes like me logo Genes that share pathways with REXO2: view

Pathways by source for REXO2 Gene

1 KEGG pathway for REXO2 Gene

Gene Ontology (GO) - Biological Process for REXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IDA 10851236
GO:0009117 nucleotide metabolic process TAS 10851236
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with REXO2: view

No data available for SIGNOR curated interactions for REXO2 Gene

Drugs & Compounds for REXO2 Gene

(1) Drugs for REXO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 37
genes like me logo Genes that share compounds with REXO2: view

Transcripts for REXO2 Gene

Unigene Clusters for REXO2 Gene

REX2, RNA exonuclease 2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - -

Relevant External Links for REXO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REXO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REXO2 Gene

Protein differential expression in normal tissues from HIPED for REXO2 Gene

This gene is overexpressed in Skin (8.1), Uterus (7.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO2 Gene

Protein tissue co-expression partners for REXO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REXO2 Gene:


SOURCE GeneReport for Unigene cluster for REXO2 Gene:


Evidence on tissue expression from TISSUES for REXO2 Gene

  • Nervous system(4.7)
  • Muscle(4.5)
  • Kidney(4.3)
  • Liver(4.2)
  • Pancreas(2.6)
genes like me logo Genes that share expression patterns with REXO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO2 Gene

Orthologs for REXO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for REXO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REXO2 33 34
  • 99.72 (n)
(Canis familiaris)
Mammalia REXO2 33 34
  • 96.2 (n)
(Bos Taurus)
Mammalia REXO2 33 34
  • 95.36 (n)
(Rattus norvegicus)
Mammalia Rexo2 33
  • 93.81 (n)
(Mus musculus)
Mammalia Rexo2 33 16 34
  • 93.11 (n)
(Monodelphis domestica)
Mammalia REXO2 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia REXO2 34
  • 89 (a)
(Gallus gallus)
Aves REXO2 33 34
  • 79.83 (n)
(Anolis carolinensis)
Reptilia REXO2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo2 33
  • 78.58 (n)
Str.1796 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9259 33
(Danio rerio)
Actinopterygii smfn 33 34
  • 74.26 (n)
zgc73191 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12624 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004759 33
  • 58.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10214 33 34
  • 52.52 (n)
(Caenorhabditis elegans)
Secernentea CELE_C08B6.8 33
  • 53.11 (n)
C08B6.8 34
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX2 33 34 36
  • 52.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08998g 33
  • 48.17 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR217C 33
  • 47.05 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26970 33
  • 54.1 (n)
(Oryza sativa)
Liliopsida Os02g0465500 33
  • 54.12 (n)
(Triticum aestivum)
Liliopsida Ta.5073 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rex2 33
  • 52.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15100 33
Species where no ortholog for REXO2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for REXO2 Gene

Gene Tree for REXO2 (if available)
Gene Tree for REXO2 (if available)

Paralogs for REXO2 Gene

No data available for Paralogs for REXO2 Gene

Variants for REXO2 Gene

Sequence variations from dbSNP and Humsavar for REXO2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000059453 -- 114,446,420(+) C/T intron_variant
rs1000076132 -- 114,443,515(+) TTCTT/TT intron_variant
rs1000407064 -- 114,439,894(+) T/G intron_variant
rs1000622071 -- 114,441,438(+) A/C intron_variant
rs1000970602 -- 114,439,294(+) C/T upstream_transcript_variant

Variation tolerance for REXO2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REXO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for REXO2 Gene

Disorders for REXO2 Gene

Additional Disease Information for REXO2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for REXO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO2 Gene

Publications for REXO2 Gene

  1. The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. (PMID: 10851236) Nguyen LH … Wilson DM (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. REXO2 is an oligoribonuclease active in human mitochondria. (PMID: 23741365) Bruni F … Chrzanowska-Lightowlers ZM (PloS one 2013) 2 3 4 58
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. (PMID: 16682444) Mechold U … Danchin A (Nucleic acids research 2006) 4 22 58

Products for REXO2 Gene

Sources for REXO2 Gene

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