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Aliases for REXO1 Gene

Aliases for REXO1 Gene

  • RNA Exonuclease 1 Homolog 2 3 5
  • Transcription Elongation Factor B Polypeptide 3-Binding Protein 1 3 4
  • Elongin-A-Binding Protein 1 3 4
  • TCEB3BP1 3 4
  • EloA-BP1 3 4
  • ELOABP1 3 4
  • Transcription Elongation Factor B Polypeptide 3 Binding Protein 1 2
  • REX1, RNA Exonuclease 1 Homolog (S. Cerevisiae) 2
  • REX1, RNA Exonuclease 1 Homolog 3
  • Elongin A Binding Protein 1 2
  • EC 3.1.-.- 4
  • KIAA1138 4
  • REX1 3

External Ids for REXO1 Gene

Previous HGNC Symbols for REXO1 Gene

  • TCEB3BP1

Previous GeneCards Identifiers for REXO1 Gene

  • GC19M001767
  • GC19M001586

Summaries for REXO1 Gene

GeneCards Summary for REXO1 Gene

REXO1 (RNA Exonuclease 1 Homolog) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is REXO5.

UniProtKB/Swiss-Prot for REXO1 Gene

  • Seems to have no detectable effect on transcription elongation in vitro.

Additional gene information for REXO1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REXO1 Gene

Genomics for REXO1 Gene

GeneHancer (GH) Regulatory Elements for REXO1 Gene

Promoters and enhancers for REXO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I001846 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.7 +0.6 643 3.7 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 ZHX2 REXO1 ATP8B3 CFD ARHGAP45 TCF3 MIDN CNN2 LOC100288123
GH19I001603 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +243.1 243071 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000267059 UQCR11 TCF3 ATP8B3 SF3A2 LOC100288123 DAZAP1 TMEM259 DOT1L PTBP1
GH19I001745 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +100.0 100037 5.8 HDGF PKNOX1 ARNT ZNF2 YY1 POLR2B ZNF766 CBX5 ZNF143 FOS ENSG00000267073 CIRBP SPPL2B AP3D1 SCAMP4 MUM1 SLC39A3 C19orf24 ATP8B3 REXO1
GH19I001667 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +180.1 180058 2.5 HDGF SMAD1 YBX1 GLI4 ZNF48 ZEB1 ZNF155 ZNF335 GLIS2 ZNF366 GC19P001669 SF3A2 TMEM259 CIRBP LOC100288123 DAZAP1 PTBP1 TCF3 RNU6-1223P ATP8B3
GH19I001939 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -93.5 -93529 5.4 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 CSNK1G2 LOC105372238 KLF16 ZNF555 SF3A2 BTBD2 CSNK1G2-AS1 PEAK3 ENSG00000267283 REXO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REXO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REXO1 gene promoter:

Genomic Locations for REXO1 Gene

Genomic Locations for REXO1 Gene
chr19:1,815,246-1,848,488
(GRCh38/hg38)
Size:
33,243 bases
Orientation:
Minus strand
chr19:1,815,245-1,848,452
(GRCh37/hg19)

Genomic View for REXO1 Gene

Genes around REXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REXO1 Gene

Proteins for REXO1 Gene

  • Protein details for REXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G1-REXO1_HUMAN
    Recommended name:
    RNA exonuclease 1 homolog
    Protein Accession:
    Q8N1G1
    Secondary Accessions:
    • Q9ULT2

    Protein attributes for REXO1 Gene

    Size:
    1221 amino acids
    Molecular mass:
    131510 Da
    Quaternary structure:
    • Interacts with TCEA2 and ELOA.
    SequenceCaution:
    • Sequence=BAA86452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REXO1 Gene

Post-translational modifications for REXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for REXO1 Gene

Domains & Families for REXO1 Gene

Gene Families for REXO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REXO1 Gene

Suggested Antigen Peptide Sequences for REXO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G1

UniProtKB/Swiss-Prot:

REXO1_HUMAN :
  • Belongs to the REXO1/REXO3 family.
Family:
  • Belongs to the REXO1/REXO3 family.
genes like me logo Genes that share domains with REXO1: view

Function for REXO1 Gene

Molecular function for REXO1 Gene

UniProtKB/Swiss-Prot Function:
Seems to have no detectable effect on transcription elongation in vitro.

Enzyme Numbers (IUBMB) for REXO1 Gene

Phenotypes From GWAS Catalog for REXO1 Gene

Gene Ontology (GO) - Molecular Function for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with REXO1: view

Phenotypes for REXO1 Gene

genes like me logo Genes that share phenotypes with REXO1: view

Animal Model Products

miRNA for REXO1 Gene

miRTarBase miRNAs that target REXO1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REXO1 Gene

Localization for REXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REXO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REXO1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with REXO1: view

Pathways & Interactions for REXO1 Gene

genes like me logo Genes that share pathways with REXO1: view

Pathways by source for REXO1 Gene

1 KEGG pathway for REXO1 Gene

Gene Ontology (GO) - Biological Process for REXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with REXO1: view

No data available for SIGNOR curated interactions for REXO1 Gene

Drugs & Compounds for REXO1 Gene

No Compound Related Data Available

Transcripts for REXO1 Gene

Unigene Clusters for REXO1 Gene

REX1, RNA exonuclease 1 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for REXO1 Gene

GeneLoc Exon Structure for
REXO1
ECgene alternative splicing isoforms for
REXO1

Expression for REXO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REXO1 Gene

Protein differential expression in normal tissues from HIPED for REXO1 Gene

This gene is overexpressed in Monocytes (48.4) and Heart (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REXO1 Gene



Protein tissue co-expression partners for REXO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of REXO1 Gene:

REXO1

SOURCE GeneReport for Unigene cluster for REXO1 Gene:

Hs.192477

mRNA Expression by UniProt/SwissProt for REXO1 Gene:

Q8N1G1-REXO1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for REXO1 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with REXO1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for REXO1 Gene

Orthologs for REXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for REXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO1 33 34
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia REXO1 33 34
  • 82.64 (n)
cow
(Bos Taurus)
Mammalia REXO1 33 34
  • 81.76 (n)
mouse
(Mus musculus)
Mammalia Rexo1 33 16 34
  • 79.12 (n)
Gm7104 34
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rexo1 33
  • 78.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves REXO1 33
  • 61.05 (n)
-- 34
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rexo1 33
  • 54.43 (n)
Str.4225 33
zebrafish
(Danio rerio)
Actinopterygii rexo1 33 34
  • 53.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12877 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.33 34
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 34
  • 17 (a)
OneToMany
Species where no ortholog for REXO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REXO1 Gene

ENSEMBL:
Gene Tree for REXO1 (if available)
TreeFam:
Gene Tree for REXO1 (if available)

Paralogs for REXO1 Gene

Paralogs for REXO1 Gene

(3) SIMAP similar genes for REXO1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with REXO1: view

Variants for REXO1 Gene

Sequence variations from dbSNP and Humsavar for REXO1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000110872 -- 1,843,433(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000140903 -- 1,850,149(-) T/C upstream_transcript_variant
rs1000372648 -- 1,829,621(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000417486 -- 1,849,884(-) G/T upstream_transcript_variant
rs1000444525 -- 1,838,163(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for REXO1 Gene

Variant ID Type Subtype PubMed ID
dgv567n67 CNV gain 20364138
esv32942 CNV gain+loss 17666407
esv3643411 CNV loss 21293372
esv3893156 CNV loss 25118596
nsv1160560 CNV deletion 26073780
nsv470107 CNV loss 18288195
nsv520344 CNV loss 19592680
nsv578337 CNV gain 21841781
nsv578338 CNV loss 21841781
nsv828384 CNV gain 20364138
nsv953942 CNV deletion 24416366

Variation tolerance for REXO1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.73; 97.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REXO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REXO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REXO1 Gene

Disorders for REXO1 Gene

Additional Disease Information for REXO1

No disorders were found for REXO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REXO1 Gene

Publications for REXO1 Gene

  1. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PMID: 12943681) Tamura K … Aso T (Biochemical and biophysical research communications 2003) 3 4 22 58
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for REXO1 Gene

Sources for REXO1 Gene

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