Aliases for REX1BD Gene

Aliases for REX1BD Gene

  • Required For Excision 1-B Domain Containing 2 3 5
  • Required For Excision 1-B Domain-Containing Protein 3 4
  • C19orf60 3 4
  • Chromosome 19 Open Reading Frame 60 2
  • Uncharacterized Protein C19orf60 3

External Ids for REX1BD Gene

Previous HGNC Symbols for REX1BD Gene

  • C19orf60

Previous GeneCards Identifiers for REX1BD Gene

  • GC19P021345
  • GC19P021720
  • GC19P019363
  • GC19P019698
  • GC19P020075
  • GC19P020991

Summaries for REX1BD Gene

GeneCards Summary for REX1BD Gene

REX1BD (Required For Excision 1-B Domain Containing) is a Protein Coding gene.

Additional gene information for REX1BD Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REX1BD Gene

Genomics for REX1BD Gene

GeneHancer (GH) Regulatory Elements for REX1BD Gene

Promoters and enhancers for REX1BD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018587 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 762.9 +0.7 741 3.7 ZBTB40 CTCF ZBTB6 MLX RBPJ SMARCE1 POLR2A USF2 ATF1 HCFC1 REX1BD piR-57461-107 ENSG00000268030 UPF1 IQCN NR2C2AP ENSG00000268938 MAU2 ENSG00000269191 MEF2B
GH19J018492 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -93.8 -93819 5.7 CTCF ZNF362 SP1 GLIS2 ZIC2 PRDM10 GATAD2A ZNF7 ZNF692 HES1 SSBP4 ELL FKBP8 UBA52 CRTC1 REX1BD ARRDC2 JUND IL12RB1 KLHL26
GH19J018484 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -101.5 -101493 4.7 CTCF L3MBTL2 RAD21 MNT NFIB ZNF148 ZFX SP1 NCOA3 SP7 KXD1 UBA52 SSBP4 CRTC1 REX1BD piR-34822-157 ELL
GH19J018498 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.9 -84.4 -84394 11.7 ZBTB40 FOXA1 MLX NR2F1 NR2F6 NFYC RAD21 ZNF121 ZNF652 ELF3 ELL SSBP4 FKBP8 KXD1 UBA52 REX1BD SUGP2 LRRC25 JUND IL12RB1
GH19J018846 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +260.1 260075 5.2 CTCF ETV6 RELA RAD21 EGR1 IKZF1 REST ZBTB8A TRIM22 IKZF2 HSALNG0124664 COMP REX1BD ENSG00000269694 HOMER3-AS1 UPF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REX1BD on UCSC Golden Path with GeneCards custom track

Genomic Locations for REX1BD Gene

Genomic Locations for REX1BD Gene
chr19:18,588,685-18,592,337
(GRCh38/hg38)
Size:
3,653 bases
Orientation:
Plus strand
chr19:18,699,495-18,703,147
(GRCh37/hg19)
Size:
3,653 bases
Orientation:
Plus strand

Genomic View for REX1BD Gene

Genes around REX1BD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REX1BD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REX1BD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REX1BD Gene

Proteins for REX1BD Gene

  • Protein details for REX1BD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EN9-REX1B_HUMAN
    Recommended name:
    Required for excision 1-B domain-containing protein
    Protein Accession:
    Q96EN9
    Secondary Accessions:
    • E9PAS0
    • Q8NAX4
    • Q9NWI0

    Protein attributes for REX1BD Gene

    Size:
    201 amino acids
    Molecular mass:
    22599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91400.1; Type=Frameshift; Positions=107; Evidence={ECO:0000305};

    Alternative splice isoforms for REX1BD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REX1BD Gene

Post-translational modifications for REX1BD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REX1BD Gene

No data available for DME Specific Peptides for REX1BD Gene

Domains & Families for REX1BD Gene

Gene Families for REX1BD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REX1BD Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with REX1BD: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for REX1BD Gene

Function for REX1BD Gene

Phenotypes From GWAS Catalog for REX1BD Gene

Gene Ontology (GO) - Molecular Function for REX1BD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with REX1BD: view
genes like me logo Genes that share phenotypes with REX1BD: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REX1BD Gene

Localization for REX1BD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REX1BD gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 0
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for REX1BD Gene

Pathways & Interactions for REX1BD Gene

PathCards logo

SuperPathways for REX1BD Gene

No Data Available

Interacting Proteins for REX1BD Gene

Gene Ontology (GO) - Biological Process for REX1BD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for REX1BD Gene

Drugs & Compounds for REX1BD Gene

No Compound Related Data Available

Transcripts for REX1BD Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REX1BD Gene

No ASD Table

Relevant External Links for REX1BD Gene

GeneLoc Exon Structure for
REX1BD
ECgene alternative splicing isoforms for
REX1BD

Expression for REX1BD Gene

NURSA nuclear receptor signaling pathways regulating expression of REX1BD Gene:

REX1BD

Evidence on tissue expression from TISSUES for REX1BD Gene

  • Nervous system(3.2)
  • Muscle(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REX1BD Gene

Orthologs for REX1BD Gene

This gene was present in the common ancestor of chordates.

Orthologs for REX1BD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf60 32
  • 98.84 (n)
C19ORF60 33
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf60 32
  • 85.29 (n)
C19orf60 33
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf60 32
  • 84.17 (n)
C19orf60 33
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2810428I15Rik 33 32
  • 80.5 (n)
OneToOne
Rex1bd 17
rat
(Rattus norvegicus)
Mammalia RGD1566239 32
  • 76.36 (n)
zebrafish
(Danio rerio)
Actinopterygii C22H19orf60 33
  • 31 (a)
OneToOne
Species where no ortholog for REX1BD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REX1BD Gene

ENSEMBL:
Gene Tree for REX1BD (if available)
TreeFam:
Gene Tree for REX1BD (if available)

Paralogs for REX1BD Gene

No data available for Paralogs for REX1BD Gene

Variants for REX1BD Gene

Sequence variations from dbSNP and Humsavar for REX1BD Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000758766 -- 18,589,973(+) T/A intron_variant
rs1001735680 -- 18,588,405(+) G/C upstream_transcript_variant
rs1002154207 -- 18,590,735(+) G/C intron_variant
rs1002749473 -- 18,592,268(+) G/A 3_prime_UTR_variant
rs1002803966 -- 18,592,616(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for REX1BD Gene

Variant ID Type Subtype PubMed ID
esv3643841 CNV loss 21293372
nsv833776 CNV loss 17160897

Variation tolerance for REX1BD Gene

Gene Damage Index Score: 1.02; 20.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REX1BD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REX1BD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REX1BD Gene

Disorders for REX1BD Gene

Additional Disease Information for REX1BD

No disorders were found for REX1BD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REX1BD Gene

Publications for REX1BD Gene

  1. A novel human protein is able to interact with hepatitis B virus core deletion mutant but not with the wild-type protein. (PMID: 19770013) Razanskas R … Sasnauskas K (Virus research 2009) 2 3 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. REX1, a novel gene required for DNA repair. (PMID: 12697762) Cenkci B … Small GD (The Journal of biological chemistry 2003) 2 3 56
  4. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for REX1BD Gene

Sources for REX1BD Gene