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Aliases for RETNLB Gene

Aliases for RETNLB Gene

  • Resistin Like Beta 2 3 5
  • Colon And Small Intestine-Specific Cysteine-Rich Protein 3 4
  • Cysteine-Rich Secreted Protein A12-Alpha-Like 1 3 4
  • Colon Carcinoma-Related Gene Protein 3 4
  • Cysteine-Rich Secreted Protein FIZZ2 3 4
  • RELMbeta 3 4
  • FIZZ2 3 4
  • HXCP2 3 4
  • C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 2 3
  • Cysteine-Rich Secreted A12-Alpha-Like Protein 1 3
  • Found In Inflammatory Zone 1 3
  • Resistin-Like Beta 3
  • RELM-Beta 3
  • RETNL2 4
  • FIZZ1 3
  • RELMb 3
  • XCP2 3
  • CCRG 4

External Ids for RETNLB Gene

Previous GeneCards Identifiers for RETNLB Gene

  • GC03M108001
  • GC03M109755
  • GC03M109794
  • GC03M109956
  • GC03M108462
  • GC03M105848

Summaries for RETNLB Gene

GeneCards Summary for RETNLB Gene

RETNLB (Resistin Like Beta) is a Protein Coding gene. Diseases associated with RETNLB include Barrett Esophagus. Among its related pathways are IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is RETN.

UniProtKB/Swiss-Prot for RETNLB Gene

  • Probable hormone.

Gene Wiki entry for RETNLB Gene

Additional gene information for RETNLB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RETNLB Gene

Genomics for RETNLB Gene

GeneHancer (GH) Regulatory Elements for RETNLB Gene

Promoters and enhancers for RETNLB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I108757 Promoter 0.6 EPDnew 550.8 0.0 -46 0.1 SCRT2 RETNLB TRAT1
GH03I108758 Enhancer 0.3 ENCODE 550.8 -0.2 -205 0.2 SCRT2 RETNLB TRAT1
GH03I108821 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 7.3 -66.8 -66765 5 CTBP1 POLR2A FEZF1 TRAT1 DZIP3 RETNLB MYH15 GC03P108894
GH03I108820 Enhancer 0.7 Ensembl ENCODE dbSUPER 6.1 -63.4 -63410 1.2 MNT TRAT1 RETNLB
GH03I108818 Enhancer 0.5 ENCODE 7.4 -61.4 -61379 0.5 CTCF ZNF143 REST PRDM1 RAD21 RETNLB TRAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RETNLB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RETNLB gene promoter:

Genomic Locations for RETNLB Gene

Genomic Locations for RETNLB Gene
13,961 bases
Minus strand

Genomic View for RETNLB Gene

Genes around RETNLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RETNLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RETNLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RETNLB Gene

Proteins for RETNLB Gene

  • Protein details for RETNLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Resistin-like beta
    Protein Accession:
    Secondary Accessions:
    • Q14D27

    Protein attributes for RETNLB Gene

    111 amino acids
    Molecular mass:
    11730 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for RETNLB Gene

Post-translational modifications for RETNLB Gene

No Post-translational modifications

Other Protein References for RETNLB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RETNLB Gene

Domains & Families for RETNLB Gene

Gene Families for RETNLB Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RETNLB Gene


Suggested Antigen Peptide Sequences for RETNLB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the resistin/FIZZ family.
  • Belongs to the resistin/FIZZ family.
genes like me logo Genes that share domains with RETNLB: view

Function for RETNLB Gene

Molecular function for RETNLB Gene

UniProtKB/Swiss-Prot Function:
Probable hormone.

Gene Ontology (GO) - Molecular Function for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IBA --
genes like me logo Genes that share ontologies with RETNLB: view
genes like me logo Genes that share phenotypes with RETNLB: view

Animal Models for RETNLB Gene

MGI Knock Outs for RETNLB:

Animal Model Products

  • Taconic Biosciences Mouse Models for RETNLB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RETNLB Gene

Localization for RETNLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RETNLB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RETNLB gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with RETNLB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RETNLB Gene

Pathways & Interactions for RETNLB Gene

genes like me logo Genes that share pathways with RETNLB: view

Pathways by source for RETNLB Gene

1 BioSystems pathway for RETNLB Gene

Interacting Proteins for RETNLB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9BQ08-RETNB_HUMAN ENSP00000295755 for RETNLB Gene via IID STRING

Gene Ontology (GO) - Biological Process for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation NAS 11209052
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with RETNLB: view

No data available for SIGNOR curated interactions for RETNLB Gene

Drugs & Compounds for RETNLB Gene

(1) Drugs for RETNLB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RETNLB: view

Transcripts for RETNLB Gene


(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RETNLB Gene

Resistin like beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RETNLB Gene

No ASD Table

Relevant External Links for RETNLB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RETNLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RETNLB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RETNLB Gene

This gene is overexpressed in Colon - Transverse (x34.1) and Small Intestine - Terminal Ileum (x16.9).

NURSA nuclear receptor signaling pathways regulating expression of RETNLB Gene:


SOURCE GeneReport for Unigene cluster for RETNLB Gene:


mRNA Expression by UniProt/SwissProt for RETNLB Gene:

Tissue specificity: Expressed only in the gastrointestinal tract, particularly the colon.

Evidence on tissue expression from TISSUES for RETNLB Gene

  • Intestine(4.6)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with RETNLB: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RETNLB Gene

Orthologs for RETNLB Gene

This gene was present in the common ancestor of chordates.

Orthologs for RETNLB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RETNLB 33 34
  • 99.4 (n)
(Canis familiaris)
Mammalia RETNLB 33
  • 75.47 (n)
(Mus musculus)
Mammalia Retnlb 33 16 34
  • 73.4 (n)
Retnlg 34
  • 51 (a)
Retnla 34
  • 41 (a)
(Rattus norvegicus)
Mammalia Retnlb 33
  • 71.43 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
-- 34
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
-- 34
  • 38 (a)
Species where no ortholog for RETNLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RETNLB Gene

Gene Tree for RETNLB (if available)
Gene Tree for RETNLB (if available)

Paralogs for RETNLB Gene

Paralogs for RETNLB Gene

(2) SIMAP similar genes for RETNLB Gene using alignment to 1 proteins: Pseudogenes for RETNLB Gene

genes like me logo Genes that share paralogs with RETNLB: view

Variants for RETNLB Gene

Sequence variations from dbSNP and Humsavar for RETNLB Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001007992 -- 108,756,229(-) T/C intron_variant
rs1001863624 -- 108,755,663(-) C/T 3_prime_UTR_variant
rs1003019335 -- 108,759,097(-) T/C upstream_transcript_variant
rs1003481156 -- 108,758,758(-) G/A/C upstream_transcript_variant
rs1003860303 -- 108,758,214(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RETNLB Gene

Variant ID Type Subtype PubMed ID
esv2670614 CNV deletion 23128226
esv3568956 CNV loss 25503493
nsv522119 CNV gain 19592680
nsv829659 CNV gain 17160897
nsv829661 CNV gain 17160897
nsv998974 CNV gain 25217958

Variation tolerance for RETNLB Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RETNLB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RETNLB Gene

Disorders for RETNLB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RETNLB Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
barrett esophagus
  • barrett metaplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RETNLB

genes like me logo Genes that share disorders with RETNLB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RETNLB Gene

Publications for RETNLB Gene

  1. Bioinformatics-based discovery of a novel factor with apparent specificity to colon cancer. (PMID: 12224133) De Young MP … Narayanan R (In vivo (Athens, Greece) 2002) 3 4 22 58
  2. A family of tissue-specific resistin-like molecules. (PMID: 11209052) Steppan CM … Lazar MA (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58
  3. Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis. (PMID: 19967544) Zheng L … Tong Q (Virchows Archiv : an international journal of pathology 2010) 3 22 58
  4. Enhanced expression of resistin-like molecule beta in human colon cancer and its clinical significance. (PMID: 18594973) Zheng LD … Hou XH (Digestive diseases and sciences 2009) 3 22 58
  5. Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia. (PMID: 16427636) Renigunta A … Hänze J (FEBS letters 2006) 3 22 58

Products for RETNLB Gene

Sources for RETNLB Gene

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