Aliases for RETNLB Gene

Aliases for RETNLB Gene

  • Resistin Like Beta 2 3 5
  • FIZZ2 2 3 4
  • HXCP2 2 3 4
  • Colon And Small Intestine-Specific Cysteine-Rich Protein 3 4
  • Cysteine-Rich Secreted Protein A12-Alpha-Like 1 3 4
  • Colon Carcinoma-Related Gene Protein 3 4
  • Cysteine-Rich Secreted Protein FIZZ2 3 4
  • Resistin-Like Beta 3 4
  • RELMbeta 3 4
  • RELMb 2 3
  • C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 2 3
  • Cysteine-Rich Secreted A12-Alpha-Like Protein 1 3
  • Found In Inflammatory Zone 1 3
  • RELM-Beta 3
  • RETNLB 5
  • RETNL2 4
  • FIZZ1 3
  • XCP2 3
  • CCRG 4

External Ids for RETNLB Gene

Previous GeneCards Identifiers for RETNLB Gene

  • GC03M108001
  • GC03M109755
  • GC03M109794
  • GC03M109956
  • GC03M108462
  • GC03M105848

Summaries for RETNLB Gene

GeneCards Summary for RETNLB Gene

RETNLB (Resistin Like Beta) is a Protein Coding gene. Diseases associated with RETNLB include Ileitis and Parasitic Helminthiasis Infectious Disease. Among its related pathways are IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is RETN.

UniProtKB/Swiss-Prot Summary for RETNLB Gene

Gene Wiki entry for RETNLB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RETNLB Gene

Genomics for RETNLB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RETNLB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J108757 Promoter 0.4 EPDnew 250.7 0.0 -20 0.1 SCRT2 RETNLB lnc-RETNLB-1 HSALNG0027918 TRAT1
GH03J108758 Enhancer 0.3 ENCODE 250.7 -0.2 -179 0.2 SCRT2 RETNLB lnc-RETNLB-1 HSALNG0027918 TRAT1
GH03J108820 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 7.3 -67.0 -66984 8.4 FEZF1 ZNF384 L3MBTL2 PKNOX1 CTBP1 POLR2A MNT HSALNG0027923 TRAT1 DZIP3 RETNLB MYH15 CIP2A HSALNG0027924 GUCA1C
GH03J108818 Enhancer 0.6 Ensembl ENCODE 7.4 -61.3 -61291 1 REST CTCF PRDM1 SMC3 RAD21 ZNF143 DZIP3 RETNLB MYH15 HSALNG0027923 TRAT1 HSALNG0027919
GH03J108805 Enhancer 0.6 Ensembl ENCODE dbSUPER 6.1 -49.2 -49190 2 YY1 DZIP3 RETNLB MYH15 TRAT1 HSALNG0027923 HSALNG0027919
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RETNLB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RETNLB

Top Transcription factor binding sites by QIAGEN in the RETNLB gene promoter:
  • C/EBPalpha
  • E47
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MyoD
  • p53
  • RORalpha1
  • Sox5
  • Tal-1beta

Genomic Locations for RETNLB Gene

Latest Assembly
13,987 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,773 bases
Minus strand

(GRCh37/hg19 by Ensembl)
13,961 bases
Minus strand

Genomic View for RETNLB Gene

Genes around RETNLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RETNLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RETNLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RETNLB Gene

Proteins for RETNLB Gene

  • Protein details for RETNLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Resistin-like beta
    Protein Accession:
    Secondary Accessions:
    • Q14D27

    Protein attributes for RETNLB Gene

    111 amino acids
    Molecular mass:
    11730 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for RETNLB Gene

Post-translational modifications for RETNLB Gene

No Post-translational modifications

Other Protein References for RETNLB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RETNLB Gene

Domains & Families for RETNLB Gene

Gene Families for RETNLB Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RETNLB Gene

  • Resistin

Suggested Antigen Peptide Sequences for RETNLB Gene

GenScript: Design optimal peptide antigens:
  • RELM-beta protein (Q2UXL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the resistin/FIZZ family.
  • Belongs to the resistin/FIZZ family.
genes like me logo Genes that share domains with RETNLB: view

Function for RETNLB Gene

Molecular function for RETNLB Gene

UniProtKB/Swiss-Prot Function:
Probable hormone.

Phenotypes From GWAS Catalog for RETNLB Gene

Gene Ontology (GO) - Molecular Function for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with RETNLB: view
genes like me logo Genes that share phenotypes with RETNLB: view

Animal Models for RETNLB Gene

MGI Knock Outs for RETNLB:

Animal Models for research

  • Taconic Biosciences Mouse Models for RETNLB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RETNLB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RETNLB Gene

Localization for RETNLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RETNLB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RETNLB gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with RETNLB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RETNLB Gene

Pathways & Interactions for RETNLB Gene

PathCards logo

SuperPathways for RETNLB Gene

SuperPathway Contained pathways
1 IL4-mediated signaling events
genes like me logo Genes that share pathways with RETNLB: view

Pathways by source for RETNLB Gene

1 BioSystems pathway for RETNLB Gene

Interacting Proteins for RETNLB Gene

Selected Interacting proteins: Q9BQ08-RETNB_HUMAN for RETNLB Gene via IID

Gene Ontology (GO) - Biological Process for RETNLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0050673 epithelial cell proliferation IEP 11209052
genes like me logo Genes that share ontologies with RETNLB: view

No data available for SIGNOR curated interactions for RETNLB Gene

Drugs & Compounds for RETNLB Gene

(1) Drugs for RETNLB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RETNLB: view

Transcripts for RETNLB Gene


7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RETNLB

Alternative Splicing Database (ASD) splice patterns (SP) for RETNLB Gene

No ASD Table

Relevant External Links for RETNLB Gene

GeneLoc Exon Structure for

Expression for RETNLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RETNLB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RETNLB Gene

This gene is overexpressed in Colon - Transverse (x34.1) and Small Intestine - Terminal Ileum (x16.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RETNLB

SOURCE GeneReport for Unigene cluster for RETNLB Gene:


mRNA Expression by UniProt/SwissProt for RETNLB Gene:

Tissue specificity: Expressed only in the gastrointestinal tract, particularly the colon.

Evidence on tissue expression from TISSUES for RETNLB Gene

  • Intestine(4.6)
  • Muscle(2.4)
  • Liver(2.4)
  • Heart(2.3)
  • Lung(2.3)
  • Blood(2.1)
  • Nervous system(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RETNLB: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RETNLB Gene

Orthologs for RETNLB Gene

This gene was present in the common ancestor of chordates.

Orthologs for RETNLB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RETNLB 29 30
  • 99.4 (n)
(Canis familiaris)
Mammalia RETNLB 29
  • 75.47 (n)
(Mus musculus)
Mammalia Retnlb 29 16 30
  • 73.4 (n)
Retnlg 30
  • 51 (a)
Retnla 30
  • 41 (a)
(Rattus norvegicus)
Mammalia Retnlb 29
  • 71.43 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 49 (a)
-- 30
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 39 (a)
-- 30
  • 38 (a)
Species where no ortholog for RETNLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RETNLB Gene

Gene Tree for RETNLB (if available)
Gene Tree for RETNLB (if available)
Evolutionary constrained regions (ECRs) for RETNLB: view image
Alliance of Genome Resources:
Additional Orthologs for RETNLB

Paralogs for RETNLB Gene

Paralogs for RETNLB Gene

(2) SIMAP similar genes for RETNLB Gene using alignment to 1 proteins:

  • RETNB_HUMAN Pseudogenes for RETNLB Gene

genes like me logo Genes that share paralogs with RETNLB: view

Variants for RETNLB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RETNLB Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11708527 -- p.Pro20Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RETNLB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RETNLB Gene

Variant ID Type Subtype PubMed ID
esv2670614 CNV deletion 23128226
esv3568956 CNV loss 25503493
nsv522119 CNV gain 19592680
nsv829659 CNV gain 17160897
nsv829661 CNV gain 17160897
nsv998974 CNV gain 25217958

Variation tolerance for RETNLB Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RETNLB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RETNLB Gene

Disorders for RETNLB Gene

MalaCards: The human disease database

(2) MalaCards diseases for RETNLB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • crohn's ileitis
parasitic helminthiasis infectious disease
  • helminth infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RETNLB

genes like me logo Genes that share disorders with RETNLB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RETNLB Gene

Publications for RETNLB Gene

  1. Bioinformatics-based discovery of a novel factor with apparent specificity to colon cancer. (PMID: 12224133) De Young MP … Narayanan R (In vivo (Athens, Greece) 2002) 3 4 22
  2. A family of tissue-specific resistin-like molecules. (PMID: 11209052) Steppan CM … Lazar MA (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22
  3. Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis. (PMID: 19967544) Zheng L … Tong Q (Virchows Archiv : an international journal of pathology 2010) 3 22
  4. Enhanced expression of resistin-like molecule beta in human colon cancer and its clinical significance. (PMID: 18594973) Zheng LD … Hou XH (Digestive diseases and sciences 2009) 3 22
  5. Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia. (PMID: 16427636) Renigunta A … Hänze J (FEBS letters 2006) 3 22

Products for RETNLB Gene

Sources for RETNLB Gene