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Aliases for RETN Gene

Aliases for RETN Gene

  • Resistin 2 3 3 5
  • C/EBP-Epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein 3 4
  • Cysteine-Rich Secreted Protein A12-Alpha-Like 2 3 4
  • Adipose Tissue-Specific Secretory Factor 3 4
  • Cysteine-Rich Secreted Protein FIZZ3 3 4
  • FIZZ3 3 4
  • ADSF 3 4
  • RSTN 3 4
  • C/EBP-Epsilon Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 1 3
  • Found In Inflammatory Zone 3 3
  • Resistin Delta2 3
  • RETN1 3
  • HXCP1 4
  • XCP1 3

External Ids for RETN Gene

Previous GeneCards Identifiers for RETN Gene

  • GC19P007838
  • GC19P007628
  • GC19P007639
  • GC19P007733
  • GC19P007403

Summaries for RETN Gene

Entrez Gene Summary for RETN Gene

  • This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for RETN Gene

RETN (Resistin) is a Protein Coding gene. Diseases associated with RETN include Diabetes Mellitus, Noninsulin-Dependent and Acquired Generalized Lipodystrophy. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Adipogenesis. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is RETNLB.

UniProtKB/Swiss-Prot for RETN Gene

  • Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).

Gene Wiki entry for RETN Gene

Additional gene information for RETN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RETN Gene

Genomics for RETN Gene

GeneHancer (GH) Regulatory Elements for RETN Gene

Promoters and enhancers for RETN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007668 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 666.2 +0.9 860 2.6 NRF1 MAX SCRT2 GLIS1 CREB1 CREM ZBTB26 MYC RETN ENSG00000268204 MCEMP1
GH19J007628 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.7 -39.5 -39457 2.7 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B XAB2 PET100 ENSG00000268400 ELAVL1 HNRNPM TRIP10 ZNF557 ENSG00000269680 RETN PCP2
GH19J008050 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 5.2 +383.4 383405 4.9 HDGF ATF1 PKNOX1 SMAD1 ARNT TCF12 POLR2B ATF7 RUNX3 SP3 CCL25 RETN MCEMP1 STXBP2 PRAM1 GC19M008058
GH19J007651 Enhancer 1.3 Ensembl ENCODE 6 -16.5 -16453 1.8 CLOCK FOXA2 MLX ARID4B DMAP1 ZNF2 IRF4 ZNF766 ZNF213 ZNF207 XAB2 RETN RPS27AP19 ENSG00000268204
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RETN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RETN gene promoter:
  • c-Jun
  • ATF-2
  • p300
  • AP-1
  • aMEF-2
  • MEF-2A
  • AML1a
  • IRF-2
  • Elk-1

Genomic Locations for RETN Gene

Genomic Locations for RETN Gene
1,411 bases
Plus strand
1,411 bases
Plus strand

Genomic View for RETN Gene

Genes around RETN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RETN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RETN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RETN Gene

Proteins for RETN Gene

  • Protein details for RETN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D6W649
    • Q540D9
    • Q76B53

    Protein attributes for RETN Gene

    108 amino acids
    Molecular mass:
    11419 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (By similarity). Interacts with DEFA1 (PubMed:15064728).

    Three dimensional structures from OCA and Proteopedia for RETN Gene

    Alternative splice isoforms for RETN Gene


neXtProt entry for RETN Gene

Post-translational modifications for RETN Gene

No Post-translational modifications

Other Protein References for RETN Gene

No data available for DME Specific Peptides for RETN Gene

Domains & Families for RETN Gene

Gene Families for RETN Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for RETN Gene


Suggested Antigen Peptide Sequences for RETN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the resistin/FIZZ family.
  • Belongs to the resistin/FIZZ family.
genes like me logo Genes that share domains with RETN: view

Function for RETN Gene

Molecular function for RETN Gene

UniProtKB/Swiss-Prot Function:
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).

Phenotypes From GWAS Catalog for RETN Gene

Gene Ontology (GO) - Molecular Function for RETN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IBA --
genes like me logo Genes that share ontologies with RETN: view
genes like me logo Genes that share phenotypes with RETN: view

Animal Models for RETN Gene

MGI Knock Outs for RETN:

Animal Model Products

  • Taconic Biosciences Mouse Models for RETN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RETN Gene

Localization for RETN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RETN Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RETN gene
Compartment Confidence
extracellular 5
lysosome 4
nucleus 3
peroxisome 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RETN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IEA --
GO:0035578 azurophil granule lumen TAS --
GO:0035580 specific granule lumen TAS --
genes like me logo Genes that share ontologies with RETN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RETN Gene

Pathways & Interactions for RETN Gene

genes like me logo Genes that share pathways with RETN: view

Pathways by source for RETN Gene

1 BioSystems pathway for RETN Gene
3 Reactome pathways for RETN Gene
1 R&D Systems pathway for RETN Gene

Interacting Proteins for RETN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9HD89-RETN_HUMAN ENSP00000221515 for RETN Gene via IID STRING

Gene Ontology (GO) - Biological Process for RETN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IEA --
GO:0008150 biological_process ND --
GO:0009612 response to mechanical stimulus IEA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0032868 response to insulin IEA --
genes like me logo Genes that share ontologies with RETN: view

No data available for SIGNOR curated interactions for RETN Gene

Drugs & Compounds for RETN Gene

(29) Drugs for RETN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(25) Additional Compounds for RETN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RETN: view

Transcripts for RETN Gene

mRNA/cDNA for RETN Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RETN Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RETN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for RETN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RETN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RETN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RETN Gene

This gene is overexpressed in Whole Blood (x44.7).

Protein differential expression in normal tissues from HIPED for RETN Gene

This gene is overexpressed in Neutrophil (26.3) and Cervix (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RETN Gene

Protein tissue co-expression partners for RETN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RETN Gene:


SOURCE GeneReport for Unigene cluster for RETN Gene:


mRNA Expression by UniProt/SwissProt for RETN Gene:

Tissue specificity: Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).

Evidence on tissue expression from TISSUES for RETN Gene

  • Nervous system(4.3)
  • Blood(3.1)
  • Bone marrow(2.5)
  • Liver(2.5)
  • Heart(2.2)
  • Lung(2.2)
  • Muscle(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with RETN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RETN Gene

Orthologs for RETN Gene

This gene was present in the common ancestor of chordates.

Orthologs for RETN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RETN 34
  • 98 (a)
(Canis familiaris)
Mammalia RETN 34 33
  • 82.77 (n)
(Bos Taurus)
Mammalia RETN 34 33
  • 82.24 (n)
(Rattus norvegicus)
Mammalia Retn 33
  • 68.89 (n)
(Mus musculus)
Mammalia Retn 16 34 33
  • 68.5 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 40 (a)
Species where no ortholog for RETN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RETN Gene

Gene Tree for RETN (if available)
Gene Tree for RETN (if available)
Evolutionary constrained regions (ECRs) for RETN: view image

Paralogs for RETN Gene

Paralogs for RETN Gene

(2) SIMAP similar genes for RETN Gene using alignment to 2 proteins:

  • Q76B53_HUMAN
genes like me logo Genes that share paralogs with RETN: view

Variants for RETN Gene

Sequence variations from dbSNP and Humsavar for RETN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000255803 -- 7,669,729(+) A/T intron_variant
rs1000609582 -- 7,667,282(+) C/T upstream_transcript_variant
rs1001611666 -- 7,668,139(+) G/A upstream_transcript_variant
rs1001642765 -- 7,667,960(+) G/A upstream_transcript_variant
rs1003252498 -- 7,668,547(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RETN Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv953959 CNV deletion 24416366
nsv960780 CNV duplication 23825009

Variation tolerance for RETN Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RETN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RETN Gene

Disorders for RETN Gene

MalaCards: The human disease database

(27) MalaCards diseases for RETN Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RETN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RETN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RETN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RETN Gene

Publications for RETN Gene

  1. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. (PMID: 19074981) Hivert MF … Florez JC (Diabetes 2009) 3 22 44 58
  2. Adiponectin and resistin gene polymorphisms in patients with anorexia nervosa and obesity and its influence on metabolic phenotype. (PMID: 17705672) Krízová J … Haluzík M (Physiological research 2008) 3 22 44 58
  3. Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. (PMID: 16670163) Menzaghi C … Trischitta V (The Journal of clinical endocrinology and metabolism 2006) 3 22 44 58
  4. The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. (PMID: 15338456) Osawa H … Makino H (American journal of human genetics 2004) 3 22 44 58
  5. Variation in resistin gene promoter not associated with polycystic ovary syndrome. (PMID: 12502516) Urbanek M … Legro RS (Diabetes 2003) 3 22 44 58

Products for RETN Gene

Sources for RETN Gene

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