Aliases for RETN Gene
External Ids for RETN Gene
Previous GeneCards Identifiers for RETN Gene
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]
GeneCards Summary for RETN Gene
RETN (Resistin) is a Protein Coding gene. Diseases associated with RETN include Type 2 Diabetes Mellitus and Acquired Generalized Lipodystrophy. Among its related pathways are Innate Immune System and Adipogenesis. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is RETNLB.
UniProtKB/Swiss-Prot Summary for RETN Gene
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).