RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009] See more...

Aliases for RERG Gene

Aliases for RERG Gene

  • RAS Like Estrogen Regulated Growth Inhibitor 2 3 5
  • Ras-Related And Estrogen-Regulated Growth Inhibitor 3 4
  • RAS-Like, Estrogen-Regulated, Growth Inhibitor 2
  • MGC15754 2
  • RERG 5

External Ids for RERG Gene

Previous GeneCards Identifiers for RERG Gene

  • GC12M015000
  • GC12M015405
  • GC12M015160

Summaries for RERG Gene

Entrez Gene Summary for RERG Gene

  • RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RERG Gene

RERG (RAS Like Estrogen Regulated Growth Inhibitor) is a Protein Coding gene. Diseases associated with RERG include Breast Cancer. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RIT1.

UniProtKB/Swiss-Prot Summary for RERG Gene

  • Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RERG Gene

Genomics for RERG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RERG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J015220 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.1 +127.6 127566 1.8 CTCF FOXA1 ZNF143 ZIC2 PATZ1 RAD21 ZNF501 TRIM22 EZH2 GTF2F1 lnc-ARHGDIB-4 RERG lnc-ARHGDIB-3 PTPRO PDE6H
GH12J015349 Promoter 1.1 EPDnew Ensembl 600.7 +0.3 274 1.2 MTA1 NKRF ATF1 HMBOX1 POLR2A ZSCAN29 EP400 TRIM28 ZNF644 GATA3 LOC105369673 RERG lnc-RERG-1 piR-40013 PTPRO
GH12J015151 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.4 +196.0 196042 2.3 CREB1 CTCF RFX1 RAD21 EZH2 ATF7 SP1 CEBPB FOS JUN RERG-AS1 RERG lnc-ARHGDIB-3 LOC107984506 PTPRO PDE6H
GH12J015627 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.2 -284.1 -284126 13.2 GATAD2A REST RCOR2 BACH1 PRDM1 RXRB TCF12 IRF2 IKZF2 SP1 lnc-RERG-2 RNU6-251P EPS8 RERG MN309452
GH12J015155 Enhancer 0.6 Ensembl ENCODE dbSUPER 8.5 +192.4 192374 2.6 NR2F2 RERG RERG-AS1 lnc-ARHGDIB-3 PTPRO PDE6H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RERG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RERG

Top Transcription factor binding sites by QIAGEN in the RERG gene promoter:
  • AML1a
  • COMP1
  • Lmo2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for RERG Gene

Genomic Locations for RERG Gene
chr12:15,107,783-15,348,675
(GRCh38/hg38)
Size:
240,893 bases
Orientation:
Minus strand
chr12:15,260,716-15,501,609
(GRCh37/hg19)
Size:
240,894 bases
Orientation:
Minus strand

Genomic View for RERG Gene

Genes around RERG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RERG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RERG Gene

Proteins for RERG Gene

  • Protein details for RERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A58-RERG_HUMAN
    Recommended name:
    Ras-related and estrogen-regulated growth inhibitor
    Protein Accession:
    Q96A58
    Secondary Accessions:
    • B2R9R0
    • B4DI02

    Protein attributes for RERG Gene

    Size:
    199 amino acids
    Molecular mass:
    22608 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RERG Gene

    Alternative splice isoforms for RERG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RERG Gene

Post-translational modifications for RERG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RERG Gene

Domains & Families for RERG Gene

Gene Families for RERG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RERG Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Ras type
ProtoNet:

Suggested Antigen Peptide Sequences for RERG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51854, highly similar to Ras-related and estrogen-regulated growth inhibitor (B4DI02_HUMAN)
  • Ras-related and estrogen-regulated growth inhibitor (RERG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96A58

UniProtKB/Swiss-Prot:

RERG_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RERG: view

Function for RERG Gene

Molecular function for RERG Gene

UniProtKB/Swiss-Prot Function:
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estradiol. Down-regulated by tamoxifen.

Phenotypes From GWAS Catalog for RERG Gene

Gene Ontology (GO) - Molecular Function for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IDA 11533059
GO:0005525 GTP binding IEA,IBA 21873635
GO:0019003 GDP binding IBA,TAS 11533059
GO:0030331 estrogen receptor binding NAS 11533059
genes like me logo Genes that share ontologies with RERG: view
genes like me logo Genes that share phenotypes with RERG: view

Animal Model Products

CRISPR Products

miRNA for RERG Gene

miRTarBase miRNAs that target RERG

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RERG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RERG Gene

Localization for RERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RERG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RERG gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11533059
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11533059
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RERG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RERG Gene

Pathways & Interactions for RERG Gene

PathCards logo

SuperPathways for RERG Gene

No Data Available

Gene Ontology (GO) - Biological Process for RERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction NAS 11533059
GO:0007265 Ras protein signal transduction IBA 21873635
GO:0008285 negative regulation of cell proliferation IDA 11533059
GO:0009725 response to hormone IDA 11533059
genes like me logo Genes that share ontologies with RERG: view

No data available for Pathways by source and SIGNOR curated interactions for RERG Gene

Drugs & Compounds for RERG Gene

(2) Drugs for RERG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for RERG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RERG: view

Transcripts for RERG Gene

mRNA/cDNA for RERG Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RERG

Alternative Splicing Database (ASD) splice patterns (SP) for RERG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for RERG Gene

GeneLoc Exon Structure for
RERG

Expression for RERG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RERG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RERG Gene

This gene is overexpressed in Uterus (x5.3) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for RERG Gene

This gene is overexpressed in Spleen (36.0) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RERG Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RERG

SOURCE GeneReport for Unigene cluster for RERG Gene:

Hs.199487

mRNA Expression by UniProt/SwissProt for RERG Gene:

Q96A58-RERG_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.

Evidence on tissue expression from TISSUES for RERG Gene

  • Nervous system(4.7)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with RERG: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RERG Gene

Orthologs for RERG Gene

This gene was present in the common ancestor of animals.

Orthologs for RERG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RERG 30 31
  • 99.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RERG 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RERG 30 31
  • 94.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RERG 30 31
  • 93.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rerg 30
  • 88.61 (n)
Mouse
(Mus musculus)
Mammalia Rerg 30 17 31
  • 88.11 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 27 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves RERG 30 31
  • 81.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RERG 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rerg 30
  • 78.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii CU694368.1 31
  • 79 (a)
OneToOne
LOC101882104 30
  • 72.36 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5160 31
  • 23 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for RERG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RERG Gene

ENSEMBL:
Gene Tree for RERG (if available)
TreeFam:
Gene Tree for RERG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RERG: view image

Paralogs for RERG Gene

genes like me logo Genes that share paralogs with RERG: view

Variants for RERG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RERG Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
769816 Benign: not provided 15,109,425(-) C/T SYNONYMOUS_VARIANT
781697 Benign: not provided 15,121,064(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
rs1555118541 Uncertain Significance: not provided 15,109,460(-) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for RERG Gene

Structural Variations from Database of Genomic Variants (DGV) for RERG Gene

Variant ID Type Subtype PubMed ID
esv8661 CNV gain 19470904
nsv619 CNV insertion 18451855
nsv620 CNV insertion 18451855

Variation tolerance for RERG Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RERG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RERG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RERG Gene

Disorders for RERG Gene

MalaCards: The human disease database

(1) MalaCards diseases for RERG Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RERG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RERG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RERG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RERG Gene

Publications for RERG Gene

  1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. (PMID: 11533059) Finlin BS … Perou CM (The Journal of biological chemistry 2001) 2 3 4 23
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 41
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood HD … Lan Q (Carcinogenesis 2008) 3 41

Products for RERG Gene

  • Signalway Proteins for RERG

Sources for RERG Gene