Aliases for RERE Gene
External Ids for RERE Gene
Previous HGNC Symbols for RERE Gene
Previous GeneCards Identifiers for RERE Gene
This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RERE Gene
RERE (Arginine-Glutamic Acid Dipeptide Repeats) is a Protein Coding gene. Diseases associated with RERE include Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart and Chromosome 1P36 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is ATN1.
UniProtKB/Swiss-Prot Summary for RERE Gene
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.