Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RENBP Gene

Aliases for RENBP Gene

  • Renin Binding Protein 2 3 5
  • N-Acetyl-D-Glucosamine 2-Epimerase 2 3 4
  • GlcNAc 2-Epimerase 2 3 4
  • N-Acylglucosamine 2-Epimerase 2 3
  • Renin-Binding Protein 2 4
  • EC 5.1.3.8 4 56
  • RNBP 3 4
  • AGE 3 4
  • RBP 3

External Ids for RENBP Gene

Previous GeneCards Identifiers for RENBP Gene

  • GC0XM147338
  • GC0XM149655
  • GC0XM150786
  • GC0XM151668
  • GC0XM152721
  • GC0XM152853
  • GC0XM153200
  • GC0XM141853

Summaries for RENBP Gene

Entrez Gene Summary for RENBP Gene

  • The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for RENBP Gene

RENBP (Renin Binding Protein) is a Protein Coding gene. Diseases associated with RENBP include Hypertension, Essential. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for RENBP Gene

  • Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Gene Wiki entry for RENBP Gene

Additional gene information for RENBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RENBP Gene

Genomics for RENBP Gene

GeneHancer (GH) Regulatory Elements for RENBP Gene

Promoters and enhancers for RENBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI153943 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.3 254 1.2 HDAC1 TFAP4 ZNF146 PKNOX1 USF1 ATF1 NFXL1 CCNT2 GLIS2 POLR2A RENBP SNORA70 HCFC1 SNORA56 PLXNA3 DKC1 NAA10
GH0XI153884 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 18.7 +58.7 58675 3 CTCF KLF1 MAX KLF17 ZIC2 RAD21 HIC1 ZFHX2 GATA3 GLIS2 L1CAM RENBP TMEM187 PDZD4 SSR4 IDH3G SRPK3 PLXNB3 ARHGAP4 NAA10
GH0XI153900 Enhancer 1.4 FANTOM5 Ensembl ENCODE 8.2 +42.3 42275 4.2 HDGF GLI4 TCF12 ZNF766 GLIS2 GATA2 ZNF143 FOS REST ATF4 AVPR2 HCFC1 SNORA70 DKC1 PLXNA3 TMEM187 SNORA56 EMD LOC105373383 SLC10A3
GH0XI154135 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 4.5 -191.8 -191843 2.1 HDAC1 ATF1 RB1 SIN3A ZBTB7B ZNF48 RAD21 ZNF335 ZNF121 GLIS2 MECP2 SNORA56 HCFC1 DKC1 IRAK1 TMEM187 PLXNA3 RENBP ARHGAP4 TAZ
GH0XI154123 Enhancer 1.4 FANTOM5 Ensembl ENCODE 4.7 -179.2 -179160 1.4 PKNOX1 SMAD1 ATF1 ARNT FEZF1 TCF12 ZNF766 GATA2 E2F8 ATF7 RENBP MECP2 ARHGAP4 IKBKG PIR60620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RENBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RENBP gene promoter:

Genomic Locations for RENBP Gene

Genomic Locations for RENBP Gene
chrX:153,935,263-153,944,780
(GRCh38/hg38)
Size:
9,518 bases
Orientation:
Minus strand
chrX:153,200,716-153,210,232
(GRCh37/hg19)

Genomic View for RENBP Gene

Genes around RENBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RENBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RENBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RENBP Gene

Proteins for RENBP Gene

  • Protein details for RENBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51606-RENBP_HUMAN
    Recommended name:
    N-acylglucosamine 2-epimerase
    Protein Accession:
    P51606
    Secondary Accessions:
    • B4DNZ3
    • Q96BI6

    Protein attributes for RENBP Gene

    Size:
    427 amino acids
    Molecular mass:
    48831 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH15558.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA01082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA01082.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for RENBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RENBP Gene

Selected DME Specific Peptides for RENBP Gene

P51606:
  • EAMIAFLMGY
  • MAVPMMLL
  • YAELGDWC

Post-translational modifications for RENBP Gene

No Post-translational modifications

Other Protein References for RENBP Gene

Domains & Families for RENBP Gene

Gene Families for RENBP Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RENBP Gene

Suggested Antigen Peptide Sequences for RENBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51606

UniProtKB/Swiss-Prot:

RENBP_HUMAN :
  • Belongs to the N-acylglucosamine 2-epimerase family.
Family:
  • Belongs to the N-acylglucosamine 2-epimerase family.
genes like me logo Genes that share domains with RENBP: view

Function for RENBP Gene

Molecular function for RENBP Gene

GENATLAS Biochemistry:
renin binding protein,involved in the regulation of the renin-angiotensin system
UniProtKB/Swiss-Prot CatalyticActivity:
N-acyl-D-glucosamine = N-acyl-D-mannosamine.
UniProtKB/Swiss-Prot Function:
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Enzyme Numbers (IUBMB) for RENBP Gene

Phenotypes From GWAS Catalog for RENBP Gene

Gene Ontology (GO) - Molecular Function for RENBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0004866 endopeptidase inhibitor activity TAS 9285790
GO:0005524 ATP binding IEA --
GO:0016853 isomerase activity IEA --
GO:0017076 purine nucleotide binding IEA --
genes like me logo Genes that share ontologies with RENBP: view
genes like me logo Genes that share phenotypes with RENBP: view

Animal Models for RENBP Gene

MGI Knock Outs for RENBP:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RENBP Gene

Localization for RENBP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RENBP gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RENBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with RENBP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RENBP Gene

Pathways & Interactions for RENBP Gene

genes like me logo Genes that share pathways with RENBP: view

UniProtKB/Swiss-Prot P51606-RENBP_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.

Gene Ontology (GO) - Biological Process for RENBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IBA,IEA --
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006051 N-acetylmannosamine metabolic process IEA --
GO:0008217 regulation of blood pressure TAS 9285790
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with RENBP: view

No data available for SIGNOR curated interactions for RENBP Gene

Drugs & Compounds for RENBP Gene

(8) Drugs for RENBP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved, Investigational Nutra Target 0
ATP Investigational Nutra Agonist 0
N-acetylmannosamine Investigational Pharma 0

(1) Additional Compounds for RENBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RENBP: view

Transcripts for RENBP Gene

Unigene Clusters for RENBP Gene

Renin binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RENBP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: - -
SP3:

Relevant External Links for RENBP Gene

GeneLoc Exon Structure for
RENBP
ECgene alternative splicing isoforms for
RENBP

Expression for RENBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RENBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RENBP Gene

This gene is overexpressed in Spleen (x5.9) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for RENBP Gene

This gene is overexpressed in Serum (33.8), Peripheral blood mononuclear cells (8.8), and Spleen (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RENBP Gene



NURSA nuclear receptor signaling pathways regulating expression of RENBP Gene:

RENBP

SOURCE GeneReport for Unigene cluster for RENBP Gene:

Hs.158331

Evidence on tissue expression from TISSUES for RENBP Gene

  • Lung(4.3)
  • Skin(4.1)
  • Kidney(3.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RENBP Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
genes like me logo Genes that share expression patterns with RENBP: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RENBP Gene

Orthologs for RENBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for RENBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RENBP 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia RENBP 33 34
  • 87.48 (n)
cow
(Bos Taurus)
Mammalia RENBP 33 34
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Renbp 33
  • 84.75 (n)
mouse
(Mus musculus)
Mammalia Renbp 33 16 34
  • 84.63 (n)
oppossum
(Monodelphis domestica)
Mammalia RENBP 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RENBP 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RENBP 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia renbp 33
  • 65.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23759 33
zebrafish
(Danio rerio)
Actinopterygii renbp 33 34
  • 63.87 (n)
Species where no ortholog for RENBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RENBP Gene

ENSEMBL:
Gene Tree for RENBP (if available)
TreeFam:
Gene Tree for RENBP (if available)

Paralogs for RENBP Gene

(4) SIMAP similar genes for RENBP Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RENBP Gene

genes like me logo Genes that share paralogs with RENBP: view

No data available for Paralogs for RENBP Gene

Variants for RENBP Gene

Sequence variations from dbSNP and Humsavar for RENBP Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1064796346 uncertain-significance, not specified 153,934,894(-) C/A downstream_transcript_variant
rs1000447894 -- 153,943,771(-) C/T intron_variant
rs1000757603 -- 153,937,589(-) C/T intron_variant
rs1000986627 -- 153,936,747(-) C/T intron_variant
rs1002014393 -- 153,942,519(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RENBP Gene

Variant ID Type Subtype PubMed ID
nsv469867 CNV loss 16826518
nsv1144325 CNV deletion 24896259
esv33199 CNV gain+loss 17666407

Variation tolerance for RENBP Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RENBP Gene

Human Gene Mutation Database (HGMD)
RENBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RENBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RENBP Gene

Disorders for RENBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for RENBP Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards
Search RENBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RENBP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RENBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RENBP Gene

Publications for RENBP Gene

  1. Angiotensin converting enzyme DD genotype is associated with hypertensive crisis. (PMID: 12394950) Sunder-Plassmann G … Födinger M (Critical care medicine 2002) 3 22 44 58
  2. Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase. (PMID: 9990133) Takahashi S … Kobayashi M (Journal of biochemistry 1999) 3 4 22 58
  3. Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males. (PMID: 9285790) Knöll A … Rosenthal A (Human molecular genetics 1997) 3 22 44 58
  4. The human gene for renin-binding protein. (PMID: 1618798) Takahashi S … Miyake Y (The Journal of biological chemistry 1992) 2 3 22 58
  5. Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif. (PMID: 1723410) Inoue H … Miyake Y (Journal of biochemistry 1991) 3 4 22 58

Products for RENBP Gene

Sources for RENBP Gene

Content
Loading form....