Aliases for REN Gene
External Ids for REN Gene
Previous GeneCards Identifiers for REN Gene
This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]
GeneCards Summary for REN Gene
REN (Renin) is a Protein Coding gene. Diseases associated with REN include Tubulointerstitial Kidney Disease, Autosomal Dominant, 4 and Renal Tubular Dysgenesis. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and endopeptidase activity. An important paralog of this gene is CTSD.
UniProtKB/Swiss-Prot Summary for REN Gene
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.