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Aliases for REM2 Gene

Aliases for REM2 Gene

  • RRAD And GEM Like GTPase 2 2 3 5
  • Rad And Gem-Like GTP-Binding Protein 2 4
  • RAS (RAD And GEM) Like GTP Binding 2 2

External Ids for REM2 Gene

Previous GeneCards Identifiers for REM2 Gene

  • GC14U990398
  • GC14P022423
  • GC14P023352
  • GC14P003469

Summaries for REM2 Gene

GeneCards Summary for REM2 Gene

REM2 (RRAD And GEM Like GTPase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RRAD.

UniProtKB/Swiss-Prot for REM2 Gene

  • Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

Additional gene information for REM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REM2 Gene

Genomics for REM2 Gene

GeneHancer (GH) Regulatory Elements for REM2 Gene

Promoters and enhancers for REM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022882 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.2 202 1.4 ATF1 NFIB ZSCAN4 MZF1 SIN3A YBX1 ZNF366 ATF7 CREM EGR2 REM2 MMP14 PRMT5 MRPL52 SLC7A7 ABHD4 HAUS4 PRMT5-AS1
GH14I022844 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12 -33.9 -33884 9.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 PIR54043 NGDN LRP10 REM2 OXA1L PABPN1 RBM23 DAD1 PRMT5-AS1 THTPA
GH14I022795 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 -85.6 -85614 3.8 PKNOX1 ATF1 FOXA2 IRF4 TCF12 ATF7 RUNX3 JUNB ZNF592 SSRP1 CDH24 PABPN1 OXA1L SLC7A7 MRPL52 MMP14 ENSG00000199716 LRP10 REM2 ENSG00000258458
GH14I022689 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.3 -192.6 -192565 3 ELF3 INSM2 RARA ZEB1 SCRT2 ZNF350 ATF7 FOS HMG20B CEBPB OXA1L SLC7A7 ACIN1 RBM23 OR6J1 MRPL52 MMP14 ENSG00000199716 LRP10 REM2
GH14I022903 Enhancer 1 ENCODE 12.8 +20.5 20451 0.9 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 HAUS4 REM2 LRP10 ENSG00000199716 PRMT5 MMP14 MRPL52 SLC7A7 PSMB11 PSMB5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REM2 gene promoter:

Genomic Locations for REM2 Gene

Genomic Locations for REM2 Gene
4,522 bases
Plus strand

Genomic View for REM2 Gene

Genes around REM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM2 Gene

Proteins for REM2 Gene

  • Protein details for REM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein REM 2
    Protein Accession:
    Secondary Accessions:
    • B7Z5P1
    • Q8N8R8

    Protein attributes for REM2 Gene

    340 amino acids
    Molecular mass:
    37139 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35663.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04746.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REM2 Gene

    Alternative splice isoforms for REM2 Gene


neXtProt entry for REM2 Gene

Post-translational modifications for REM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM2 Gene

No data available for DME Specific Peptides for REM2 Gene

Domains & Families for REM2 Gene

Gene Families for REM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for REM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. RGK family.
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM2: view

Function for REM2 Gene

Molecular function for REM2 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

Phenotypes From GWAS Catalog for REM2 Gene

Gene Ontology (GO) - Molecular Function for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with REM2: view
genes like me logo Genes that share phenotypes with REM2: view

miRNA for REM2 Gene

miRTarBase miRNAs that target REM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REM2 Gene

Localization for REM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REM2 Gene

Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REM2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with REM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for REM2 Gene

Pathways & Interactions for REM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:1901842 negative regulation of high voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with REM2: view

No data available for Pathways by source and SIGNOR curated interactions for REM2 Gene

Drugs & Compounds for REM2 Gene

(1) Drugs for REM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with REM2: view

Transcripts for REM2 Gene

mRNA/cDNA for REM2 Gene

Unigene Clusters for REM2 Gene

RAS (RAD and GEM)-like GTP binding 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for REM2 Gene

No ASD Table

Relevant External Links for REM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REM2 Gene

This gene is overexpressed in Whole Blood (x21.9).

Protein differential expression in normal tissues from HIPED for REM2 Gene

This gene is overexpressed in Fetal Brain (38.1), Frontal cortex (24.0), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REM2 Gene

Protein tissue co-expression partners for REM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of REM2 Gene:


SOURCE GeneReport for Unigene cluster for REM2 Gene:


Evidence on tissue expression from TISSUES for REM2 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with REM2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REM2 Gene

Orthologs for REM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REM2 33 34
  • 99.51 (n)
(Bos Taurus)
Mammalia REM2 33 34
  • 91.76 (n)
(Canis familiaris)
Mammalia REM2 33 34
  • 89.61 (n)
(Mus musculus)
Mammalia Rem2 33 16 34
  • 87.65 (n)
(Rattus norvegicus)
Mammalia Rem2 33
  • 87.35 (n)
(Ornithorhynchus anatinus)
Mammalia REM2 34
  • 85 (a)
(Monodelphis domestica)
Mammalia REM2 34
  • 81 (a)
(Anolis carolinensis)
Reptilia REM2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rem2 33
  • 61.48 (n)
(Danio rerio)
Actinopterygii rem2 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgk3 34
  • 19 (a)
Rgk1 34
  • 17 (a)
Rgk2 34
  • 12 (a)
CG42541 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea Y52B11A.4 34
  • 17 (a)
Species where no ortholog for REM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for REM2 Gene

Gene Tree for REM2 (if available)
Gene Tree for REM2 (if available)

Paralogs for REM2 Gene

Paralogs for REM2 Gene

(22) SIMAP similar genes for REM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REM2: view

Variants for REM2 Gene

Sequence variations from dbSNP and Humsavar for REM2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000301415 -- 22,887,831(+) A/G downstream_transcript_variant
rs1000373201 -- 22,884,458(+) G/A 5_prime_UTR_variant, intron_variant
rs1000526895 -- 22,883,027(+) G/T upstream_transcript_variant
rs1000741557 -- 22,886,315(+) T/C intron_variant
rs1001308106 -- 22,881,252(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for REM2 Gene

Variant ID Type Subtype PubMed ID
nsv1214 CNV deletion 18451855

Variation tolerance for REM2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM2 Gene

Disorders for REM2 Gene

Additional Disease Information for REM2

No disorders were found for REM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REM2 Gene

Publications for REM2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. (PMID: 10727423) Finlin BS … Andres DA (The Biochemical journal 2000) 2 3 58
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  5. A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity. (PMID: 23991227) Moore AR … Paradis S (PloS one 2013) 3 58

Products for REM2 Gene

Sources for REM2 Gene

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