The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008] See more...

Aliases for REM1 Gene

Aliases for REM1 Gene

  • RRAD And GEM Like GTPase 1 2 3 5
  • GES 2 3 4
  • GTPase-Regulating Endothelial Cell Sprouting 3 4
  • GTP-Binding Protein REM 1 3 4
  • Rad And Gem-Like GTP-Binding Protein 1 4
  • RAS (RAD And GEM)-Like GTP-Binding 1 3
  • RAS (RAD And GEM)-Like GTP-Binding 2
  • GTPase GES 2
  • GD:REM 3
  • REM1 5
  • REM 4

External Ids for REM1 Gene

Previous HGNC Symbols for REM1 Gene

  • REM

Previous GeneCards Identifiers for REM1 Gene

  • GC20P030809
  • GC20P029526
  • GC20P030063
  • GC20P026851

Summaries for REM1 Gene

Entrez Gene Summary for REM1 Gene

  • The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for REM1 Gene

REM1 (RRAD And GEM Like GTPase 1) is a Protein Coding gene. Diseases associated with REM1 include Mobitz Type Ii Atrioventricular Block and Mental Retardation, Autosomal Dominant 10. Gene Ontology (GO) annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity. An important paralog of this gene is RRAD.

UniProtKB/Swiss-Prot Summary for REM1 Gene

  • Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REM1 Gene

Genomics for REM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for REM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J031474 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 +0.2 203 1.4 PRDM10 CREB1 PKNOX1 PRDM4 FOS ZNF24 EZH2 DEFB124 REM1 DEFB123 lnc-DEFB124-2
GH20J031475 Promoter 0.5 Ensembl 600.7 -1.2 -1172 0.2 NR3C1 ATF4 MG828730-041 REM1 piR-36393-306 piR-50417-027 piR-43583-325 DEFB124 lnc-DEFB124-2 DEFB123
GH20J031513 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +40.6 40628 4.6 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 ZNF512 RFX1 IKZF1 NFKBIZ HM13 ASXL1 DEFB124 TM9SF4 MCTS2P REM1 PLAGL2 piR-33614-174 LOC107985416
GH20J031894 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 +420.0 420028 2.2 SP1 CREB1 ZNF629 RFX5 ZNF143 SMAD5 IKZF2 POLR2A EED ZNF140 piR-50443-237 ASXL1 TM9SF4 MCTS2P DNMT3B TSPY26P BAK1P1 REM1 C20orf203 POFUT1
GH20J032336 Enhancer 1.2 Ensembl ENCODE dbSUPER 10 +865.0 865028 7.4 GATAD2A CTCF ATF7 RCOR2 JUND ZNF143 RXRB REST RAD21 IRF2 ASXL1 ENSG00000236772 MIR1825 RSL24D1P6 REM1 TSPY26P MYLK2 NOL4L ENSG00000277692 piR-57133-361
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REM1

Top Transcription factor binding sites by QIAGEN in the REM1 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • Elk-1
  • Evi-1
  • HEN1
  • Meis-1
  • Meis-1a

Genomic Locations for REM1 Gene

Genomic Locations for REM1 Gene
chr20:31,475,273-31,484,895
(GRCh38/hg38)
Size:
9,623 bases
Orientation:
Plus strand
chr20:30,063,096-30,072,708
(GRCh37/hg19)
Size:
9,613 bases
Orientation:
Plus strand

Genomic View for REM1 Gene

Genes around REM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REM1 Gene

Proteins for REM1 Gene

  • Protein details for REM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75628-REM1_HUMAN
    Recommended name:
    GTP-binding protein REM 1
    Protein Accession:
    O75628
    Secondary Accessions:
    • E1P5L1
    • Q5TZR7
    • Q5TZR8
    • Q9NP57

    Protein attributes for REM1 Gene

    Size:
    298 amino acids
    Molecular mass:
    32947 Da
    Quaternary structure:
    • In vitro, interacts with calmodulin in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for REM1 Gene

neXtProt entry for REM1 Gene

Post-translational modifications for REM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for REM1 Gene

No data available for DME Specific Peptides for REM1 Gene

Domains & Families for REM1 Gene

Gene Families for REM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REM1 Gene

Suggested Antigen Peptide Sequences for REM1 Gene

GenScript: Design optimal peptide antigens:
  • Rad and Gem-like GTP-binding protein 1 (REM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75628

UniProtKB/Swiss-Prot:

REM1_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with REM1: view

Function for REM1 Gene

Molecular function for REM1 Gene

UniProtKB/Swiss-Prot Function:
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Gene Ontology (GO) - Molecular Function for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005246 calcium channel regulator activity IBA 21873635
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with REM1: view

Phenotypes for REM1 Gene

genes like me logo Genes that share phenotypes with REM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REM1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REM1 Gene

Localization for REM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REM1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with REM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for REM1 Gene

Pathways & Interactions for REM1 Gene

PathCards logo

SuperPathways for REM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for REM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:1901842 negative regulation of high voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with REM1: view

No data available for Pathways by source and SIGNOR curated interactions for REM1 Gene

Drugs & Compounds for REM1 Gene

(1) Drugs for REM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556

(1) Additional Compounds for REM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REM1: view

Transcripts for REM1 Gene

mRNA/cDNA for REM1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REM1

Alternative Splicing Database (ASD) splice patterns (SP) for REM1 Gene

No ASD Table

Relevant External Links for REM1 Gene

GeneLoc Exon Structure for
REM1

Expression for REM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REM1 Gene

This gene is overexpressed in Pancreatic juice (25.7), Uterus (24.0), and Heart (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REM1 Gene



Protein tissue co-expression partners for REM1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REM1

SOURCE GeneReport for Unigene cluster for REM1 Gene:

Hs.247729

mRNA Expression by UniProt/SwissProt for REM1 Gene:

O75628-REM1_HUMAN
Tissue specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Evidence on tissue expression from TISSUES for REM1 Gene

  • Nervous system(4.5)
  • Lymph node(4.3)
  • Kidney(2.6)
  • Skin(2.5)
  • Blood(2.4)
  • Heart(2.3)
  • Muscle(2.3)
  • Intestine(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with REM1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for REM1 Gene

Orthologs for REM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for REM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia REM1 30 31
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia REM1 30 31
  • 89.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia REM1 30 31
  • 87.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rem1 30
  • 87.09 (n)
Mouse
(Mus musculus)
Mammalia Rem1 30 17 31
  • 85.19 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia REM1 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves REM1 30 31
  • 67.92 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia REM1 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rem1 30
  • 60.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii rem1 30 31
  • 64.63 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Rgk2 30 31
  • 50.41 (n)
ManyToMany
Rgk3 31
  • 19 (a)
ManyToMany
Rgk1 31
  • 19 (a)
ManyToMany
CG42541 31
  • 7 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007615 30
  • 47.9 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 31
  • 15 (a)
OneToMany
Species where no ortholog for REM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for REM1 Gene

ENSEMBL:
Gene Tree for REM1 (if available)
TreeFam:
Gene Tree for REM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for REM1: view image

Paralogs for REM1 Gene

(18) SIMAP similar genes for REM1 Gene using alignment to 1 proteins:

  • REM1_HUMAN
genes like me logo Genes that share paralogs with REM1: view

Variants for REM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REM1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
729544 Benign: not provided 31,484,290(+) A/G MISSENSE_VARIANT
rs550409143 Likely Benign: Long QT syndrome 31,482,440(+) G/A MISSENSE_VARIANT
rs1006459 - p.His28Arg
rs2233829 - p.Pro59Ala
rs59730832 - p.Arg45Trp

Additional dbSNP identifiers (rs#s) for REM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for REM1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
esv2763228 CNV gain 21179565
nsv458961 CNV gain 19166990
nsv470546 CNV gain 18288195
nsv585911 CNV gain 21841781

Variation tolerance for REM1 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.39; 92.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REM1 Gene

Disorders for REM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for REM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mobitz type ii atrioventricular block
  • mobitz ii atrioventricular block
mental retardation, autosomal dominant 10
  • mrd10
syndromic x-linked intellectual disability snyder type
  • mental retardation, x-linked, syndromic, snyder-robinson type
long qt syndrome
  • romano-ward syndrome
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search REM1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with REM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REM1 Gene

Publications for REM1 Gene

  1. Ges, A human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. (PMID: 10831614) Pan JY … Silberstein DS (The Journal of cell biology 2000) 2 3 4 23
  2. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. (PMID: 14623965) Finlin BS … Andres DA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 23
  3. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. (PMID: 22076634) Jhun BS … Jin ZG (Circulation research 2012) 2 3
  4. L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. (PMID: 16648185) Crump SM … Satin J (American journal of physiology. Heart and circulatory physiology 2006) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for REM1 Gene

Sources for REM1 Gene