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Aliases for RELB Gene
Aliases for RELB Gene
- RELB Proto-Oncogene, NF-KB Subunit 2 3 5
- V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3) 2 3
- Transcription Factor RelB 3 4
- REL-B 2 3
- V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 3
External Ids for RELB Gene
- HGNC: 9956
- Entrez Gene: 5971
- Ensembl: ENSG00000104856
- OMIM: 604758
- UniProtKB: Q01201
Previous GeneCards Identifiers for RELB Gene
- GC19P046149
- GC19P045895
- GC19P050180
- GC19P050196
- GC19P045504
- GC19P041935
Summaries for RELB Gene
GeneCards Summary for RELB Gene
RELB (RELB Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELB include Immunodeficiency 53 and Rheumatoid Arthritis. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RELA.
UniProtKB/Swiss-Prot Summary for RELB Gene
-
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).
Additional gene information for RELB Gene
- HGNC(9956)
- Entrez Gene(5971)
- Ensembl(ENSG00000104856)
- OMIM(604758)
- UniProtKB(Q01201)
- Open Targets Platform(ENSG00000104856)
- Search for RELB at DataMed
- Search for RELB at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RELB Gene
Genomics for RELB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RELB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RELB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RELB
- Top Transcription factor binding sites by QIAGEN in the RELB gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- GR
- GR-alpha
- GR-beta
- STAT3
Genomic Locations for RELB Gene
Genomic Locations for RELB Gene
- chr19:45,001,449-45,038,198
- (GRCh38/hg38)
- Size:
- 36,750 bases
- Orientation:
- Plus strand
- chr19:45,504,688-45,541,456
- (GRCh37/hg19)
- Size:
- 36,769 bases
- Orientation:
- Plus strand
Genomic View for RELB Gene
Genes around RELB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
RELB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RELB Gene
Proteins for RELB Gene
-
Protein details for RELB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01201-RELB_HUMAN
- Recommended name:
- Transcription factor RelB
- Protein Accession:
- Q01201
- Q6GTX7
- Q9UEI7
Protein attributes for RELB Gene
- Size:
- 579 amino acids
- Molecular mass:
- 62134 Da
- Quaternary structure:
-
- Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).
Protein Expression for RELB Gene
Post-translational modifications for RELB Gene
- Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RELB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RelB Antibody and Immunotag™ Phospho-RelB (Ser552) Antibody
-
Custom Antibody ServicesOriGene Antibodies for RELB
- Novus Biologicals Antibodies for RELB
-
Abcam antibodies for RELB
- Invitrogen Antibodies for RELB (AFLGC-RELB)
- antibodies-online: Show 44 available RELB Antibodies ranked by validation data
- Compare Top RELB Antibodies
-
Recommended
- 95 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 127 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 36 IF (p) Antibodies (anti-rat)
- 34 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for RELB
-
Santa Cruz Biotechnology (SCBT) Antibodies for RELB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RELB
- Origene Custom Protein Services for RELB
-
Signalway Proteins for RELB
-
Abcam proteins for RELB
Assay Products
-
Signalway ELISA kits for RELB
No data available for DME Specific Peptides for RELB Gene
Domains & Families for RELB Gene
Gene Families for RELB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RELB Gene
- InterPro:
- Blocks:
-
- Cell surface receptor IPT/TIG
- NF-kappa-B/Rel/dorsal family
- Rel homology
- ProtoNet:
Suggested Antigen Peptide Sequences for RELB Gene
- GenScript: Design optimal peptide antigens:
-
- V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (Avian) (D6R992_HUMAN)
- I-Rel (RELB_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01201UniProtKB/Swiss-Prot:
RELB_HUMAN :- Both N- and C-terminal domains are required for transcriptional activation.
- Domain:
-
- Both N- and C-terminal domains are required for transcriptional activation.
Function for RELB Gene
Molecular function for RELB Gene
- UniProtKB/Swiss-Prot Function:
- NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by mitogens and NUPR1.
Phenotypes From GWAS Catalog for RELB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IBA | 21873635 |
Phenotypes for RELB Gene
- MGI mutant phenotypes for RELB:
-
inferred from 4 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for RELB:
Animal Models for RELB Gene
- MGI Knock Outs for RELB:
-
- Relb Relb<tm1Brv>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RELB - Select products 50% OFF >
- * RELB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RELB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RELB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELB
miRNA for RELB Gene
- miRTarBase miRNAs that target RELB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RELB
- Browse OriGene Inhibitory RNA Products For RELB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RELB
Clone Products
- Applied Biological Materials (abm): Clones for RELB - Select products 50% OFF >
- * RELB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RELB
- Addgene plasmids for RELB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RELB
Cell Line Products
-
Horizon Cell Lines for RELB
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RELB Gene
Localization for RELB Gene
Subcellular locations from UniProtKB/Swiss-Prot for RELB Gene
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IDA | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | colocalizes_with centrosome | IDA | 20873783 |
Pathways & Interactions for RELB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
| 2 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
| 3 | CLEC7A (Dectin-1) signaling | ||
| 4 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
| 5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
Pathways by source for RELB Gene
4 Sino Biological pathways for RELB Gene
8 BioSystems pathways for RELB Gene
9 Reactome pathways for RELB Gene
1 PharmGKB pathway for RELB Gene
47 GeneGo (Thomson Reuters) pathways for RELB Gene
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
- Apoptosis and survival APRIL and BAFF signaling
- Apoptosis and survival Lymphotoxin-beta receptor signaling
- Apoptosis and survival TNFR1 signaling pathway
8 R&D Systems pathways for RELB Gene
2 Qiagen pathways for RELB Gene
- LT-BetaR Pathway
- NF-KappaB Family Pathway
1 Cell Signaling Technology pathway for RELB Gene
Interacting Proteins for RELB Gene
Selected Interacting proteins:
Q01201-RELB_HUMAN
ENSP00000221452
for RELB Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RELB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006954 | inflammatory response | IBA | 21873635 |
Drugs & Compounds for RELB Gene
(3) ApexBio Compounds for RELB Gene
| Compound | Action | Cas Number |
|---|---|---|
| JSH-23 | NF-κB inhibitor | 749886-87-1 |
| QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Transcripts for RELB Gene
mRNA/cDNA for RELB Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000221452 2258 nts (view in UCSC)
- ENST00000505236 2219 nts (view in UCSC)
- ENST00000509229 775 nts (view in UCSC)
- ENST00000509480 840 nts (view in UCSC)
- ENST00000510184 546 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RELB - Select products 50% OFF >
- * RELB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RELB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RELB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RELB
- Browse OriGene Inhibitory RNA Products For RELB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RELB
Clone Products
- Applied Biological Materials (abm): Clones for RELB - Select products 50% OFF >
- * RELB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RELB
- Addgene plasmids for RELB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RELB
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | - | - |
Relevant External Links for RELB Gene
- GeneLoc Exon Structure for
- RELB
Expression for RELB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for RELB Gene
This gene is overexpressed in Whole Blood (x5.3).
This gene is overexpressed in Heart (27.2), Blymphocyte (19.2), and Peripheral blood mononuclear cells (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RELB Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RELB
SOURCE GeneReport for Unigene cluster for RELB Gene:
Hs.654402Evidence on tissue expression from TISSUES for RELB Gene
- Blood(4.6)
- Lymph node(3.2)
- Spleen(3.1)
- Bone marrow(3)
- Intestine(2.8)
- Liver(2.6)
- Kidney(2.6)
- Skin(2.5)
- Heart(2.5)
- Nervous system(2.5)
- Lung(2.5)
- Muscle(2.3)
- Stomach(2.2)
- Pancreas(2.2)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for RELB
-
OriGene qPCR primer pairs and template standards for RELB
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RELB Gene
Orthologs for RELB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RELB 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RELB 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RELB 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Relb 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Relb 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RELB 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RELB 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | relb 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | relb-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | relb 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | dl 31 32 |
|
ManyToMany | |
| Dif 31 32 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for RELB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RELB Gene
- ENSEMBL:
- Gene Tree for RELB (if available)
- TreeFam:
- Gene Tree for RELB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RELB: view image
Paralogs for RELB Gene
Variants for RELB Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RELB Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708621 | Benign: not provided | 45,012,129(+) | G/A | SYNONYMOUS_VARIANT | |
| 709499 | Benign: not provided | 45,012,177(+) | G/A | SYNONYMOUS_VARIANT | |
| 714790 | Benign: not provided | 45,037,541(+) | A/G | SYNONYMOUS_VARIANT | |
| 798850 | Likely Benign: not provided | 45,032,598(+) | C/T | SYNONYMOUS_VARIANT | |
| 872128 | Likely Pathogenic: not provided | 45,022,211(+) | G/T | SPLICE_DONOR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1071536 | CNV | deletion | 25765185 |
| nsv1116334 | CNV | deletion | 24896259 |
| nsv1121553 | CNV | deletion | 24896259 |
| nsv1127688 | CNV | deletion | 24896259 |
| nsv1151982 | CNV | deletion | 26484159 |
| nsv954658 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.59;
12.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RELB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELB Gene
Disorders for RELB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 53 |
|
|
| rheumatoid arthritis |
|
|
| skin disease |
|
|
| prostate cancer |
|
|
| lymphoma, mucosa-associated lymphoid type |
|
|
Search RELB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RELB_HUMAN- Immunodeficiency 53 (IMD53) [MIM:617585]: An autosomal recessive primary immunodeficiency apparent from early infancy and resulting in recurrent infections, severe autoimmune skin disease rheumatoid arthritis, and failure to thrive. Immunologic workup shows increased CD4+/CD8+ ratio, impaired T-cell proliferative response to multiple antigen, T-cell developmental and functional defects, and impaired ability to produce specific immunoglobulins. {ECO:0000269 PubMed:26385063}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RELB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for RELB Gene
Publications for RELB Gene
- Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PMID: 8441398) Dobrzanski P … Bravo R (Molecular and cellular biology 1993) 3 4 23
- The effects of RelB deficiency on lymphocyte development and function. (PMID: 26385063) Sharfe N … Roifman CM (Journal of autoimmunity 2015) 3 4
- Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4
- Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio. (PMID: 20353939) de Jong SJ … Biesinger B (The Journal of biological chemistry 2010) 3 23
- p52-Independent nuclear translocation of RelB promotes LPS-induced attachment. (PMID: 19903458) Saito T … Longo DL (Biochemical and biophysical research communications 2010) 3 23
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