Aliases for RELB Gene
Aliases for RELB Gene
- RELB Proto-Oncogene, NF-KB Subunit 2 3 5
- V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3) 2 3
- I-REL 3 4
- V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 3
- Transcription Factor RelB 3
- IMD53 3
- REL-B 3
- IREL 3
External Ids for RELB Gene
- HGNC: 9956
- Entrez Gene: 5971
- Ensembl: ENSG00000104856
- OMIM: 604758
- UniProtKB: Q01201
Previous GeneCards Identifiers for RELB Gene
- GC19P046149
- GC19P045895
- GC19P050180
- GC19P050196
- GC19P045504
- GC19P041935
Summaries for RELB Gene
GeneCards Summary for RELB Gene
RELB (RELB Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELB include Immunodeficiency 53 and Reticuloendotheliosis. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RELA.
UniProtKB/Swiss-Prot for RELB Gene
-
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RELB Gene
Genomics for RELB Gene
GeneHancer (GH) Regulatory Elements for RELB Gene
Promoters and enhancers for RELB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RELB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RELB Gene
Genomic Locations for RELB Gene
- chr19:45,001,430-45,038,198
- (GRCh38/hg38)
- Size:
- 36,769 bases
- Orientation:
- Plus strand
- chr19:45,504,688-45,541,456
- (GRCh37/hg19)
Genomic View for RELB Gene
Genes around RELB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.32 by Entrez Gene
- 19q13.32 by HGNC
RELB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RELB Gene
Proteins for RELB Gene
-
Protein details for RELB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01201-RELB_HUMAN
- Recommended name:
- Transcription factor RelB
- Protein Accession:
- Q01201
- Q6GTX7
- Q9UEI7
Protein attributes for RELB Gene
- Size:
- 579 amino acids
- Molecular mass:
- 62134 Da
- Quaternary structure:
-
- Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).
Protein Expression for RELB Gene
Post-translational modifications for RELB Gene
- Phosphorylation at Thr-103 and Ser-573 is followed by proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RELB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RELB (RelB)
-
Custom Antibody ServicesOriGene Antibodies for RELB
- Novus Biologicals Antibodies for RELB
-
Abcam antibodies for RELB
-
Cloud-Clone Corp. Antibodies for RELB
- Invitrogen Antibodies for RELB
- antibodies-online: Search results for 166 available RELB Antibodies ranked by validation data
- Compare Top RELB Antibodies
-
Recommended
- 2 IHC Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 38 WB Antibodies (anti-rat)
- 1 PLA Antibody (anti-human)
- 1 FACS Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 111 WB Antibodies (anti-human)
- 2 IHC Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 84 WB Antibodies (anti-mouse)
- GeneTex RELB antibody for RELB
-
Santa Cruz Biotechnology (SCBT) Antibodies for RELB
Protein Products
-
OriGene Purified Proteins for RELB
- Search Origene for MassSpec and Protein Over-expression Lysates for RELB
- Origene Custom Protein Services for RELB
-
Cloud-Clone Corp. Proteins for RELB
- Search GeneTex for Proteins for RELB
-
Abcam proteins for RELB
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for RELB (RelB)
-
Cloud-Clone Corp. Assay Kits for RELB
No data available for DME Specific Peptides for RELB Gene
Domains & Families for RELB Gene
Gene Families for RELB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RELB Gene
Suggested Antigen Peptide Sequences for RELB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q01201UniProtKB/Swiss-Prot:
RELB_HUMAN :- Both N- and C-terminal domains are required for transcriptional activation.
- Domain:
-
- Both N- and C-terminal domains are required for transcriptional activation.
Function for RELB Gene
Molecular function for RELB Gene
- UniProtKB/Swiss-Prot Function:
- NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by mitogens and NUPR1.
Phenotypes From GWAS Catalog for RELB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0001047 | core promoter binding | ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IBA | -- |
Phenotypes for RELB Gene
- MGI mutant phenotypes for RELB:
-
inferred from 4 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for RELB:
Animal Models for RELB Gene
- MGI Knock Outs for RELB:
-
- Relb tm1Brv
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RELB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RELB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RELB gene
- Search ViGene Biosciences for RELB
CRISPR Products
-
OriGene CRISPR knockouts for RELB
- genomics-online: gRNA clones - Search results for available RELB gene related products
- Applied Biological Materials CRISPR for RELB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELB
- GenScript: Design CRISPR guide RNA sequences for RELB
miRNA for RELB Gene
- miRTarBase miRNAs that target RELB
miRNA Products
- Search ViGene Biosciences for RELB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RELB
- Browse OriGene Inhibitory RNA Products For RELB
- genomics-online: shRNA clones - Search results for available RELB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RELB gene
Clone Products
- Sino Biological Human cDNA Clone for RELB
- VectorBuilder custom plasmid, inducible vectors for RELB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RELB
- genomics-online: cdna clones - Search results for available RELB gene related products
- orf clones - Search results for available RELB gene related products
- Applied Biological Materials Clones for RELB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RELB
-
ViGene Biosciences adenoviral particle packaged cDNA for RELB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RELB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RELB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RELB Gene
Localization for RELB Gene
Subcellular locations from UniProtKB/Swiss-Prot for RELB Gene
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | colocalizes_with centrosome | IDA | 20873783 |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for RELB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response NFAT in immune response | ||
| 2 | IL-1 Family Signaling Pathways | ||
| 3 | CLEC7A (Dectin-1) signaling | ||
| 4 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 5 | Bacterial infections in CF airways | ||
Pathways by source for RELB Gene
7 BioSystems pathways for RELB Gene
9 Reactome pathways for RELB Gene
1 PharmGKB pathway for RELB Gene
5 KEGG pathways for RELB Gene
47 GeneGo (Thomson Reuters) pathways for RELB Gene
10 R&D Systems pathways for RELB Gene
2 Qiagen pathways for RELB Gene
1 Cell Signaling Technology pathway for RELB Gene
Interacting Proteins for RELB Gene
Selected Interacting proteins:
Q01201-RELB_HUMAN
ENSP00000221452
for RELB Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
Drugs & Compounds for RELB Gene
(3) ApexBio Compounds for RELB Gene
| Compound | Action | Cas Number |
|---|---|---|
| JSH-23 | NF-κB inhibitor | 749886-87-1 |
| QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Transcripts for RELB Gene
mRNA/cDNA for RELB Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (87) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RELB Gene
CRISPR Products
-
OriGene CRISPR knockouts for RELB
- genomics-online: gRNA clones - Search results for available RELB gene related products
- Applied Biological Materials CRISPR for RELB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RELB
- GenScript: Design CRISPR guide RNA sequences for RELB
miRNA Products
- Search ViGene Biosciences for RELB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RELB
- Browse OriGene Inhibitory RNA Products For RELB
- genomics-online: shRNA clones - Search results for available RELB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RELB gene
Clone Products
- Sino Biological Human cDNA Clone for RELB
- VectorBuilder custom plasmid, inducible vectors for RELB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RELB
- genomics-online: cdna clones - Search results for available RELB gene related products
- orf clones - Search results for available RELB gene related products
- Applied Biological Materials Clones for RELB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | - | - |
Expression for RELB Gene
mRNA differential expression in normal tissues according to GTEx for RELB Gene
This gene is overexpressed in Whole Blood (x5.3).
This gene is overexpressed in Heart (27.2), Blymphocyte (19.2), and Peripheral blood mononuclear cells (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RELB Gene
NURSA nuclear receptor signaling pathways regulating expression of RELB Gene:
RELBSOURCE GeneReport for Unigene cluster for RELB Gene:
Hs.654402Evidence on tissue expression from TISSUES for RELB Gene
- Blood(4.5)
- Lymph node(2.9)
- Spleen(2.9)
- Bone marrow(2.5)
Primer Products
-
OriGene qPCR primer pairs for RELB
-
OriGene qPCR primer pairs and template standards for RELB
- genomics-online: primer clones - Search results for available RELB gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RELB Gene
Orthologs for RELB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RELB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RELB 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RELB 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Relb 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Relb 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RELB 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RELB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | relb 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | relb-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | relb 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dl 35 34 |
|
||
| Dif 35 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for RELB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RELB Gene
(3) SIMAP similar genes for RELB Gene using alignment to 4 proteins:
Variants for RELB Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs745463649 | pathogenic, IMMUNODEFICIENCY 53 | 45,032,733(+) | C/A/T | coding_sequence_variant, intron_variant, stop_gained, synonymous_variant | |
| rs1000129253 | -- | 45,035,785(+) | C/T | intron_variant | |
| rs1000212702 | -- | 45,004,571(+) | G/A | intron_variant | |
| rs1000215506 | -- | 45,006,703(+) | G/A | intron_variant | |
| rs1000265513 | -- | 45,036,233(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1071536 | CNV | deletion | 25765185 |
| nsv1116334 | CNV | deletion | 24896259 |
| nsv1121553 | CNV | deletion | 24896259 |
| nsv1127688 | CNV | deletion | 24896259 |
| nsv1151982 | CNV | deletion | 26484159 |
| nsv954658 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.59;
12.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RELB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RELB
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RELB Gene
Disorders for RELB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 53 |
|
|
| reticuloendotheliosis |
|
|
Search RELB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RELB_HUMAN- Immunodeficiency 53 (IMD53) [MIM:617585]: An autosomal recessive primary immunodeficiency apparent from early infancy and resulting in recurrent infections, severe autoimmune skin disease rheumatoid arthritis, and failure to thrive. Immunologic workup shows increased CD4+/CD8+ ratio, impaired T-cell proliferative response to multiple antigen, T-cell developmental and functional defects, and impaired ability to produce specific immunoglobulins. {ECO:0000269 PubMed:26385063}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RELB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RELB Gene
Publications for RELB Gene
- Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. (PMID: 8441398) Dobrzanski P … Bravo R (Molecular and cellular biology 1993) 3 4 22 58
- The effects of RelB deficiency on lymphocyte development and function. (PMID: 26385063) Sharfe N … Roifman CM (Journal of autoimmunity 2015) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4 58
- p52-Independent nuclear translocation of RelB promotes LPS-induced attachment. (PMID: 19903458) Saito T … Longo DL (Biochemical and biophysical research communications 2010) 3 22 58
Products for RELB Gene
- R&D Systems Antibodies for RELB (RelB)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for RELB (RelB)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RELB
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RELB
- Search Origene for MassSpec and Protein Over-expression Lysates for RELB
- Origene Custom Protein Services for RELB
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RELB
- Browse OriGene Inhibitory RNA Products For RELB
- OriGene qPCR primer pairs and template standards for RELB
- OriGene qPCR primer pairs for RELB
- OriGene CRISPR knockouts for RELB
- OriGene ORF clones in human for RELB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RELB
- GenScript: Next-day shipping of latest version cDNA ORF clones for RELB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RELB
- GenScript Custom Assay Services for RELB
- GenScript Custom overexpressing Cell Line Services for RELB
- GenScript: Design CRISPR guide RNA sequences for RELB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RELB
- Sino Biological Human cDNA Clone for RELB
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for RELB
- Novus Biologicals lysates and proteins for RELB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RELB
- Abcam proteins for RELB
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for RELB
- Cloud-Clone Corp. Proteins for RELB
- Cloud-Clone Corp. Assay Kits for RELB
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for RELB
- Cyagen custom Knockout/knockin (KOKI) mouse models for RELB
- VectorBuilder custom plasmid, inducible vectors for RELB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RELB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RELB
- antibodies-online: Search results for 166 available RELB Antibodies ranked by validation data
- Compare Top RELB Antibodies
- Recommended
- 84 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 111 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 38 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Search results for 23 available RELB Elisa Kits ranked by validation data
- Compare Top RELB Elisa Kits
- antibodies-online: Search results for 10 available RELB Proteins ranked by validation data
- Compare Top RELB Proteins
- GeneTex RELB antibody for RELB
- Search GeneTex for Proteins for RELB
- ViGene Biosciences adenoviral particle packaged cDNA for RELB gene
- ViGene Biosciences lentiviral particle packaged cDNA for RELB gene
- ViGene Biosciences ready-to-package AAV shRNAs for RELB gene
- Search ViGene Biosciences for RELB
- Santa Cruz Biotechnology (SCBT) Antibodies for RELB
- Search Santa Cruz Biotechnology (SCBT) for RELB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RELB
- Horizon Cell Lines for RELB
- genomics-online: cdna clones - Search results for available RELB gene related products
- orf clones - Search results for available RELB gene related products
- genomics-online: gRNA clones - Search results for available RELB gene related products
- genomics-online: primer clones - Search results for available RELB gene related products
- genomics-online: shRNA clones - Search results for available RELB gene related products
Sources for RELB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems