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RELB (RELB Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELB include Immunodeficiency 53 and Rheumatoid Arthritis. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RELA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IDA | 22065573 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005813 | colocalizes_with centrosome | IDA | 20873783 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
2 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
3 | CLEC7A (Dectin-1) signaling | ||
4 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006954 | inflammatory response | IBA | 21873635 |
Compound | Action | Cas Number |
---|---|---|
JSH-23 | NF-κB inhibitor | 749886-87-1 |
QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RELB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RELB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RELB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Relb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Relb 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RELB 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RELB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | relb 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | relb-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | relb 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | dl 31 32 |
|
ManyToMany | |
Dif 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708621 | Benign: not provided | 45,012,129(+) | G/A | SYNONYMOUS_VARIANT | |
709499 | Benign: not provided | 45,012,177(+) | G/A | SYNONYMOUS_VARIANT | |
714790 | Benign: not provided | 45,037,541(+) | A/G | SYNONYMOUS_VARIANT | |
798850 | Likely Benign: not provided | 45,032,598(+) | C/T | SYNONYMOUS_VARIANT | |
872128 | Likely Pathogenic: not provided | 45,022,211(+) | G/T | SPLICE_DONOR_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1071536 | CNV | deletion | 25765185 |
nsv1116334 | CNV | deletion | 24896259 |
nsv1121553 | CNV | deletion | 24896259 |
nsv1127688 | CNV | deletion | 24896259 |
nsv1151982 | CNV | deletion | 26484159 |
nsv954658 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 53 |
|
|
rheumatoid arthritis |
|
|
skin disease |
|
|
prostate cancer |
|
|
lymphoma, mucosa-associated lymphoid type |
|
|