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NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
RELA (RELA Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELA include Mucocutaneous Ulceration, Chronic and Rela Fusion-Positive Ependymoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is REL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 17350185 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 18045535 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA,ISS | 21329555 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 21343296 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA,ISM | 19274049 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA,ISA | -- |
GO:0005634 | nucleus | IEA,IMP | 9425125 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IDA | 12048232 |
GO:0005730 | NOT nucleolus | IDA | 21343177 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Cytosolic sensors of pathogen-associated DNA | ||
3 | Toll-Like receptor Signaling Pathways |
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