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This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this... See more...
Aliases for REL Gene
Aliases for REL Gene
External Ids for REL Gene
- HGNC: 9954
- NCBI Entrez Gene: 5966
- Ensembl: ENSG00000162924
- OMIM®: 164910
- UniProtKB/Swiss-Prot: Q04864
Previous GeneCards Identifiers for REL Gene
- GC02P061237
- GC02P061067
- GC02P061083
- GC02P061020
- GC02P061108
- GC02P060851
Summaries for REL Gene
-
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
GeneCards Summary for REL Gene
REL (REL Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with REL include B-Cell Lymphoma and Primary Mediastinal B-Cell Lymphoma. Among its related pathways are Immune response IL-23 signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is RELA.
UniProtKB/Swiss-Prot Summary for REL Gene
-
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Additional gene information for REL Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REL Gene
Genomics for REL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for REL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around REL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REL
- Top Transcription factor binding sites by QIAGEN in the REL gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- C/EBPbeta
- IRF-1
- IRF-7A
- Sp1
Genomic Locations for REL Gene
Latest Assembly
- chr2:60,881,521-60,931,612
- (GRCh38/hg38)
- Size:
- 50,092 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:61,108,709-61,158,747
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 50,039 bases
- Orientation:
- Plus strand
Genomic View for REL Gene
Genes around REL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by HGNC
- 2p16.1 by Entrez Gene
- 2p16.1 by Ensembl
REL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for REL Gene
Proteins for REL Gene
-
Protein details for REL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04864-REL_HUMAN
- Recommended name:
- Proto-oncogene c-Rel
- Protein Accession:
- Q04864
- Q17RU2
- Q2PNZ7
- Q6LDY0
Protein attributes for REL Gene
- Size:
- 619 amino acids
- Molecular mass:
- 68520 Da
- Quaternary structure:
-
- Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE.
Protein Expression for REL Gene
Post-translational modifications for REL Gene
Other Protein References for REL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences REL / C-Rel Antibody (LS-B6495) and REL / C-Rel Antibody (LS-B8927)
- GeneTex Anti-c-Rel antibody and Anti-c-Rel antibody [N1N3]
-
Custom Antibody ServicesOriGene Antibodies for REL
- Novus Biologicals Antibodies for REL
-
Abcam antibodies for REL
- Invitrogen Antibodies for REL (AFLGC-REL)
- antibodies-online: Show 530 available p65 Antibodies ranked by validation data
- Compare Top p65 Antibodies
-
Recommended
- 911 WB Antibodies (anti-human)
- 96 IF (p) Antibodies (anti-human)
- 50 IHC Antibodies (anti-human)
- 30 FACS Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 5 DB Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 4 ICS Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 PLA Antibodies (anti-human)
- 1 GS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 413 WB Antibodies (anti-rat)
- 84 IF (p) Antibodies (anti-rat)
- 34 IHC Antibodies (anti-rat)
- 15 IHC (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 2 BCA Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- 531 WB Antibodies (anti-mouse)
- 84 IF (p) Antibodies (anti-mouse)
- 38 IHC Antibodies (anti-mouse)
- 22 FACS Antibodies (anti-mouse)
- 14 IHC (p) Antibodies (anti-mouse)
- 4 EIA Antibodies (anti-mouse)
- 2 BCA Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
-
Boster Bio Antibodies for REL
-
Santa Cruz Biotechnology (SCBT) Antibodies for REL
Protein products for research
-
OriGene Purified Proteins for REL
- Search Origene for MassSpec and Protein Over-expression Lysates for REL
- Origene Custom Protein Services for REL
- Novus Biologicals proteins for REL
- antibodies-online: Show 15 available p65 Proteins ranked by validation data
- Compare Top p65 Proteins
-
Abcam proteins for REL
Assay products for research
- antibodies-online: Show 100 available p65 Elisa Kits ranked by validation data
- Compare Top p65 Elisa Kits
-
Quality Products:
- ABIN4889784
- ABIN965407
- ABIN366831
- ABIN414493
- ABIN1572167
- ABIN1116223
- ABIN5665066
- ABIN5524696
- ABIN2748433
- ABIN2685361
- ABIN367915
- ABIN1116222
- ABIN1572168
- ABIN5524697
- ABIN628131
- ABIN773475
- ABIN1380658
- ABIN1380657
- ABIN1116224
- ABIN368280
- ABIN416166
- ABIN1572169
- ABIN5524698
- ABIN627317
- ABIN772132
- ABIN628480
- ABIN775296
- ABIN1564746
- ABIN6229176
No data available for DME Specific Peptides for REL Gene
Domains & Families for REL Gene
Gene Families for REL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for REL Gene
- InterPro:
- Blocks:
-
- Cell surface receptor IPT/TIG
- NF-kappa-B/Rel/dorsal family
- Rel homology
Suggested Antigen Peptide Sequences for REL Gene
- GenScript: Design optimal peptide antigens:
-
- Proto-oncogene c-Rel (REL_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for REL Gene
Function for REL Gene
Molecular function for REL Gene
- UniProtKB/Swiss-Prot Function:
- Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
- GENATLAS Biochemistry:
- avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell lymphoma)
Phenotypes From GWAS Catalog for REL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 1406630 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 1406630 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA,NAS | 8423996 |
Phenotypes for REL Gene
- MGI mutant phenotypes for REL:
-
inferred from 8 alleles
- normal phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for REL:
Animal Models for REL Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for REL - Starting at $85 >
- * REL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for REL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REL
-
Santa Cruz Biotechnology (SCBT) CRISPR for REL
miRNA for REL Gene
- miRTarBase miRNAs that target REL
-
- hsa-miR-98-5p (MIRT027520)
- hsa-miR-3611 (MIRT469388)
- hsa-miR-1257 (MIRT469390)
- hsa-miR-95-5p (MIRT469391)
- hsa-miR-365b-3p (MIRT469392)
- hsa-miR-365a-3p (MIRT469393)
- hsa-miR-511-5p (MIRT469394)
- hsa-miR-1229-5p (MIRT469395)
- hsa-miR-1225-5p (MIRT469396)
- hsa-miR-4540 (MIRT469397)
- hsa-miR-4524b-5p (MIRT469398)
- hsa-miR-4524a-5p (MIRT469399)
- hsa-miR-4711-3p (MIRT469400)
- hsa-miR-6830-3p (MIRT469401)
- hsa-miR-503-3p (MIRT469402)
- hsa-miR-107 (MIRT469403)
- hsa-miR-103a-3p (MIRT469404)
- hsa-miR-3121-5p (MIRT469405)
- hsa-miR-6838-3p (MIRT469406)
- hsa-miR-646 (MIRT469407)
- hsa-miR-503-5p (MIRT469408)
- hsa-miR-6838-5p (MIRT469409)
- hsa-miR-497-5p (MIRT469410)
- hsa-miR-424-5p (MIRT469411)
- hsa-miR-195-5p (MIRT469412)
- hsa-miR-16-5p (MIRT469413)
- hsa-miR-15b-5p (MIRT469414)
- hsa-miR-15a-5p (MIRT469415)
- hsa-miR-4482-5p (MIRT469416)
- hsa-miR-3130-5p (MIRT469417)
- hsa-miR-1912 (MIRT469418)
- hsa-miR-1295b-5p (MIRT469419)
- hsa-miR-202-5p (MIRT469420)
- hsa-miR-337-3p (MIRT469421)
- hsa-miR-1260b (MIRT469422)
- hsa-miR-1260a (MIRT469423)
- hsa-miR-582-5p (MIRT469424)
- hsa-miR-101-3p (MIRT469425)
- hsa-miR-4326 (MIRT469426)
- hsa-miR-4433a-5p (MIRT469427)
- hsa-miR-1224-3p (MIRT469428)
- hsa-miR-5588-3p (MIRT469429)
- hsa-miR-4709-5p (MIRT469430)
- hsa-miR-548t-5p (MIRT469431)
- hsa-miR-548az-5p (MIRT469432)
- hsa-miR-548n (MIRT469433)
- hsa-miR-145-5p (MIRT469434)
- hsa-miR-4446-5p (MIRT469435)
- hsa-miR-7977 (MIRT469436)
- hsa-miR-767-5p (MIRT469437)
- hsa-miR-4729 (MIRT469438)
- hsa-miR-3065-3p (MIRT469439)
- hsa-miR-501-5p (MIRT469440)
- hsa-miR-135a-3p (MIRT469441)
- hsa-miR-6822-5p (MIRT469442)
- hsa-miR-6750-5p (MIRT469443)
- hsa-miR-5584-5p (MIRT469444)
- hsa-miR-500a-5p (MIRT469445)
- hsa-miR-3121-3p (MIRT469446)
- hsa-miR-29c-3p (MIRT469447)
- hsa-miR-29b-3p (MIRT469448)
- hsa-miR-29a-3p (MIRT469449)
- hsa-miR-3689d (MIRT469450)
- hsa-miR-7641 (MIRT469451)
- hsa-miR-6879-3p (MIRT469452)
- hsa-miR-3650 (MIRT469453)
- hsa-miR-3652 (MIRT469454)
- hsa-miR-4430 (MIRT469455)
- hsa-miR-122-5p (MIRT469456)
- hsa-miR-504-3p (MIRT469457)
- hsa-miR-3135b (MIRT469458)
- hsa-miR-4746-3p (MIRT469459)
- hsa-miR-4695-3p (MIRT469460)
- hsa-miR-6787-3p (MIRT469461)
- hsa-miR-500b-3p (MIRT469462)
- hsa-miR-2054 (MIRT554805)
- hsa-miR-527 (MIRT554806)
- hsa-miR-518a-5p (MIRT554807)
- hsa-miR-548aw (MIRT554808)
- hsa-miR-3686 (MIRT554809)
- hsa-miR-524-5p (MIRT554810)
- hsa-miR-520d-5p (MIRT554811)
- hsa-miR-4742-3p (MIRT554812)
- hsa-miR-92b-3p (MIRT554813)
- hsa-miR-92a-3p (MIRT554814)
- hsa-miR-367-3p (MIRT554815)
- hsa-miR-363-3p (MIRT554816)
- hsa-miR-32-5p (MIRT554817)
- hsa-miR-25-3p (MIRT554818)
- hsa-miR-4778-5p (MIRT554819)
- hsa-miR-380-3p (MIRT554820)
- hsa-miR-34c-3p (MIRT554821)
- hsa-miR-3163 (MIRT554822)
- hsa-miR-300 (MIRT554823)
- hsa-miR-381-3p (MIRT554824)
- hsa-miR-1264 (MIRT566053)
- hsa-miR-3680-3p (MIRT614448)
- hsa-miR-557 (MIRT614449)
- hsa-miR-507 (MIRT614450)
- hsa-miR-450b-5p (MIRT614451)
- hsa-miR-6516-5p (MIRT614452)
- hsa-miR-3678-3p (MIRT614453)
- hsa-miR-2467-3p (MIRT614454)
- hsa-miR-1273h-3p (MIRT614455)
- hsa-miR-4524a-3p (MIRT614456)
- hsa-miR-656-3p (MIRT614457)
- hsa-miR-329-5p (MIRT614458)
- hsa-miR-4524b-3p (MIRT614459)
- hsa-miR-3927-5p (MIRT622483)
- hsa-miR-4286 (MIRT622484)
- hsa-miR-136-3p (MIRT622485)
- hsa-miR-548c-3p (MIRT622486)
- hsa-miR-6509-5p (MIRT629818)
- hsa-miR-4713-5p (MIRT629819)
- hsa-miR-331-5p (MIRT629820)
- hsa-miR-2116-3p (MIRT629821)
- hsa-miR-532-3p (MIRT629822)
- hsa-miR-150-5p (MIRT629823)
- hsa-miR-4667-3p (MIRT629824)
- hsa-miR-1470 (MIRT629825)
- hsa-miR-6887-3p (MIRT629826)
- hsa-miR-6866-3p (MIRT629827)
- hsa-miR-188-5p (MIRT629828)
- hsa-miR-4678 (MIRT629829)
- hsa-miR-3064-3p (MIRT700210)
- hsa-miR-1227-3p (MIRT700211)
- hsa-miR-1250-3p (MIRT700212)
- hsa-miR-4289 (MIRT700213)
- hsa-miR-455-5p (MIRT700214)
- hsa-miR-382-3p (MIRT700215)
- hsa-miR-302b-5p (MIRT700216)
- hsa-miR-874-3p (MIRT700217)
- hsa-miR-6873-3p (MIRT700218)
- hsa-miR-593-3p (MIRT700219)
- hsa-miR-6895-3p (MIRT700220)
- hsa-miR-4261 (MIRT700221)
- hsa-miR-146b-3p (MIRT700222)
- hsa-miR-6799-3p (MIRT700223)
- hsa-miR-3173-5p (MIRT700224)
- hsa-miR-7976 (MIRT700225)
- hsa-miR-6817-3p (MIRT700226)
- hsa-miR-7110-3p (MIRT700227)
- hsa-miR-4716-5p (MIRT700228)
- hsa-miR-3688-3p (MIRT700229)
- hsa-miR-371b-3p (MIRT700230)
- hsa-miR-4802-3p (MIRT700231)
- hsa-miR-7-5p (MIRT732230)
- hsa-miR-1304-3p (MIRT762426)
- hsa-miR-215-3p (MIRT763846)
- hsa-miR-3664-5p (MIRT766520)
- hsa-miR-4639-3p (MIRT770551)
- hsa-miR-6773-3p (MIRT778716)
- hsa-miR-6794-3p (MIRT779339)
Transcription Factor Targets for REL Gene
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REL
- Browse OriGene Inhibitory RNA Products For REL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REL
Clone products for research
- Applied Biological Materials (abm): Clones for REL - Starting at $45 >
- * REL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for REL
- Addgene plasmids for REL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REL
Cell Lines for research
-
Horizon Cell Lines for REL
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for REL Gene
Localization for REL Gene
Subcellular locations from UniProtKB/Swiss-Prot for REL Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IMP | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for REL Gene
Pathways & Interactions for REL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
| 2 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
| 3 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
| 4 | Development A3 receptor signaling |
Development A1 receptor signaling
.65
Development A3 receptor signaling
.65
|
G-protein signaling G-Protein alpha-q signaling cascades
.53
|
| 5 | Development IGF-1 receptor signaling |
Development IGF-1 receptor signaling
.48
Signal transduction AKT signaling
.48
|
Immune response IL-4 signaling pathway
.38
|
Pathways by source for REL Gene
5 Sino Biological pathways for REL Gene
10 BioSystems pathways for REL Gene
5 Reactome pathways for REL Gene
1 PharmGKB pathway for REL Gene
3 KEGG pathways for REL Gene
46 GeneGo (Thomson Reuters) pathways for REL Gene
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
- Apoptosis and survival TNFR1 signaling pathway
- Bacterial infections in CF airways
- Cytokine production by Th17 cells in CF
7 R&D Systems pathways for REL Gene
3 Qiagen pathways for REL Gene
- Activation of NF-KappaB by PKR
- NF-KappaB Family Pathway
- PKR Pathway
1 Cell Signaling Technology pathway for REL Gene
Interacting Proteins for REL Gene
Selected Interacting proteins:
Q04864-REL_HUMAN
ENSP00000295025
for REL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for REL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006954 | inflammatory response | IBA | 21873635 |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IEA,IBA | 21873635 |
| GO:0010629 | negative regulation of gene expression | IDA | 22065573 |
Drugs & Compounds for REL Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for REL Gene
| Compound | Action | Cas Number |
|---|---|---|
| JSH-23 | NF-κB inhibitor | 749886-87-1 |
| QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Transcripts for REL Gene
mRNA/cDNA for REL Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000295025 11255 nts (view in UCSC)
- ENST00000394479 11108 nts (view in UCSC)
- ENST00000642725 2156 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for REL - Starting at $85 >
- * REL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for REL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REL
-
Santa Cruz Biotechnology (SCBT) CRISPR for REL
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REL
- Browse OriGene Inhibitory RNA Products For REL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REL
Clone products for research
- Applied Biological Materials (abm): Clones for REL - Starting at $45 >
- * REL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for REL
- Addgene plasmids for REL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REL
Relevant External Links for REL Gene
- GeneLoc Exon Structure for
- REL
Expression for REL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
mRNA differential expression in normal tissues according to GTEx for REL Gene
This gene is overexpressed in Whole Blood (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (18.6) and Monocytes (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for REL Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REL
SOURCE GeneReport for Unigene cluster for REL Gene:
Hs.631886Evidence on tissue expression from TISSUES for REL Gene
- Intestine(4.6)
- Spleen(3.4)
- Blood(3.2)
- Lung(3.1)
- Nervous system(3.1)
- Skin(2.9)
- Heart(2.9)
- Lymph node(2.9)
- Kidney(2.8)
- Muscle(2.8)
- Liver(2.8)
- Bone marrow(2.8)
- Pancreas(2.5)
- Eye(2)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for REL
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REL Gene
Orthologs for REL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | REL 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | REL 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | REL 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rel 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rel 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | REL 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | REL 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | REL 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | REL 30 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | rel-A 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rel 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rel 31 |
|
|
|
| dl 30 31 |
|
ManyToMany | |||
| Dif 30 31 |
|
ManyToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.770 29 |
|
- Species where no ortholog for REL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for REL Gene
- ENSEMBL:
- Gene Tree for REL (if available)
- TreeFam:
- Gene Tree for REL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for REL: view image
- Alliance of Genome Resources:
- Additional Orthologs for REL
Paralogs for REL Gene
Variants for REL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REL Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 871169 | Pathogenic: not provided | 60,921,756(+) |
C/A NM_001291746.2(REL):c.992-7C>A |
INTRON | |
| rs140572082 | Benign: not provided | 60,921,972(+) |
A/G NM_001291746.2(REL):c.1201A>G (p.Thr401Ala) |
MISSENSE | |
| rs34661029 | Benign: not provided | 60,921,853(+) |
C/G NM_001291746.2(REL):c.1082C>G (p.Pro361Arg) |
MISSENSE | |
| rs6729789 | Benign: not provided | 60,894,435(+) |
A/G NM_001291746.2(REL):c.192A>G (p.Thr64=) |
SYNONYMOUS | |
| rs751888284 | Likely Benign: not provided | 60,922,427(+) |
T/G NM_001291746.2(REL):c.1656T>G (p.Thr552=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6908n54 | CNV | gain | 21841781 |
| nsv1127728 | CNV | deletion | 24896259 |
| nsv1134866 | CNV | deletion | 24896259 |
| nsv2749 | CNV | insertion | 18451855 |
| nsv524802 | CNV | loss | 19592680 |
| nsv834215 | CNV | loss | 17160897 |
| nsv953131 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.84;
34.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for REL Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REL Gene
Disorders for REL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| b-cell lymphoma |
|
|
| primary mediastinal b-cell lymphoma |
|
|
| lymphoma |
|
|
| colitis |
|
|
| ulcerative colitis |
|
|
Search REL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for REL
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for REL Gene
Publications for REL Gene
- Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. (PMID: 8152812) Beg AA … Baldwin AS (Oncogene 1994) 3 4 22
- Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. (PMID: 22170493) Ellinghaus E … Franke A (The Journal of investigative dermatology 2012) 3 40
- Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 40
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 40
ExternalLinks
Products for REL Gene
- Custom Antibody ServicesOriGene Antibodies for REL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for REL
- Search Origene for MassSpec and Protein Over-expression Lysates for REL
- Origene Custom Protein Services for REL
- Origene shrna, sirna, and RNAi products in human, mouse, rat for REL
- Browse OriGene Inhibitory RNA Products For REL
- OriGene qPCR primer pairs for REL
- OriGene CRISPR knockouts for REL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For REL
- Sino Biological Human cDNA Clone for REL
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals proteins for REL
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Abcam antibodies for REL
- Abcam proteins for REL
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for REL (AFLGC-REL)
- ApexBio compounds for REL
- VectorBuilder Custom and pre-made DNA vectors for REL (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for REL (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for REL
- Addgene plasmids for REL
- antibodies-online: Show 530 available p65 Antibodies ranked by validation data
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- 5 DB Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 4 ICS Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 PLA Antibodies (anti-human)
- 1 GS Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 413 WB Antibodies (anti-rat)
- 84 IF (p) Antibodies (anti-rat)
- 34 IHC Antibodies (anti-rat)
- 15 IHC (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 2 BCA Antibodies (anti-rat)
- 1 IP Antibody (anti-rat)
- 531 WB Antibodies (anti-mouse)
- 84 IF (p) Antibodies (anti-mouse)
- 38 IHC Antibodies (anti-mouse)
- 22 FACS Antibodies (anti-mouse)
- 14 IHC (p) Antibodies (anti-mouse)
- 4 EIA Antibodies (anti-mouse)
- 2 BCA Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- antibodies-online: Show 100 available p65 Elisa Kits ranked by validation data
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- antibodies-online: Show 15 available p65 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for REL
- Search Santa Cruz Biotechnology (SCBT) for REL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for REL
- Custom Antibody ServicesProSci Antibodies for REL
- Search for REL Proteins at ProSci
- Horizon Cell Lines for REL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for REL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for REL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for REL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REL
Sources for REL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5)