Aliases for REL Gene
Aliases for REL Gene
External Ids for REL Gene
- HGNC: 9954
- Entrez Gene: 5966
- Ensembl: ENSG00000162924
- OMIM: 164910
- UniProtKB: Q04864
Previous GeneCards Identifiers for REL Gene
- GC02P061237
- GC02P061067
- GC02P061083
- GC02P061020
- GC02P061108
- GC02P060851
Summaries for REL Gene
-
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
GeneCards Summary for REL Gene
REL (REL Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with REL include Reticuloendotheliosis and B-Cell Lymphomas. Among its related pathways are Bacterial infections in CF airways and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is RELA.
UniProtKB/Swiss-Prot for REL Gene
-
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Additional gene information for REL Gene
- Monarch Initiative
- Search for REL at DataMed
- Search for REL at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REL Gene
Genomics for REL Gene
GeneHancer (GH) Regulatory Elements for REL Gene
Promoters and enhancers for REL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around REL on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for REL Gene
Genomic Locations for REL Gene
- chr2:60,881,495-60,931,610
- (GRCh38/hg38)
- Size:
- 50,116 bases
- Orientation:
- Plus strand
- chr2:61,108,656-61,158,745
- (GRCh37/hg19)
Genomic View for REL Gene
Genes around REL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by Ensembl
- 2p16.1 by Entrez Gene
- 2p16.1 by HGNC
REL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for REL Gene
Proteins for REL Gene
-
Protein details for REL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04864-REL_HUMAN
- Recommended name:
- Proto-oncogene c-Rel
- Protein Accession:
- Q04864
- Q17RU2
- Q2PNZ7
- Q6LDY0
Protein attributes for REL Gene
- Size:
- 619 amino acids
- Molecular mass:
- 68520 Da
- Quaternary structure:
-
- Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE.
Protein Expression for REL Gene
Post-translational modifications for REL Gene
Other Protein References for REL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for REL (c-Rel)
-
Custom Antibody ServicesOriGene Antibodies for REL
- Novus Biologicals Antibodies for REL
-
Abcam antibodies for REL
- Invitrogen Antibodies for REL
- antibodies-online: Search results for 1 available REL Antibodies ranked by validation data
- Compare Top REL Antibodies
-
Quality Products:
- GeneTex REL antibody for REL
-
Santa Cruz Biotechnology (SCBT) Antibodies for REL
Protein Products
-
OriGene Purified Proteins for REL
- Search Origene for MassSpec and Protein Over-expression Lysates for REL
- Origene Custom Protein Services for REL
- Novus Biologicals proteins for REL
- antibodies-online: Search results for available REL related products ranked by validation data
- Search GeneTex for Proteins for REL
-
Abcam proteins for REL
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for REL (c-Rel)
- antibodies-online: Search results for available REL related products ranked by validation data
No data available for DME Specific Peptides for REL Gene
Domains & Families for REL Gene
Gene Families for REL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for REL Gene
Suggested Antigen Peptide Sequences for REL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for REL Gene
Function for REL Gene
Molecular function for REL Gene
- GENATLAS Biochemistry:
- avian reticuloendotheliosis viral (v-rel) oncogene homolog,involved in lymphomagenesis (diffuse large B cell lymphoma)
- UniProtKB/Swiss-Prot Function:
- Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Phenotypes From GWAS Catalog for REL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 1406630 |
| GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 1406630 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0003700 | DNA binding transcription factor activity | NAS | 8423996 |
Phenotypes for REL Gene
- MGI mutant phenotypes for REL:
-
inferred from 6 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for REL:
Animal Models for REL Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for REL
-
-
ViGene Biosciences lentiviral particle packaged cDNA for REL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for REL gene
- Search ViGene Biosciences for REL
CRISPR Products
-
OriGene CRISPR knockouts for REL
- genomics-online: gRNA clones - Search results for available REL gene related products
- Applied Biological Materials CRISPR for REL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for REL
- GenScript: Design CRISPR guide RNA sequences for REL
miRNA for REL Gene
- miRTarBase miRNAs that target REL
-
- hsa-mir-98-5p (MIRT027520)
- hsa-mir-3611 (MIRT469388)
- hsa-mir-1257 (MIRT469390)
- hsa-mir-95-5p (MIRT469391)
- hsa-mir-365b-3p (MIRT469392)
- hsa-mir-365a-3p (MIRT469393)
- hsa-mir-511-5p (MIRT469394)
- hsa-mir-1229-5p (MIRT469395)
- hsa-mir-1225-5p (MIRT469396)
- hsa-mir-4540 (MIRT469397)
- hsa-mir-4524b-5p (MIRT469398)
- hsa-mir-4524a-5p (MIRT469399)
- hsa-mir-4711-3p (MIRT469400)
- hsa-mir-6830-3p (MIRT469401)
- hsa-mir-503-3p (MIRT469402)
- hsa-mir-107 (MIRT469403)
- hsa-mir-103a-3p (MIRT469404)
- hsa-mir-3121-5p (MIRT469405)
- hsa-mir-6838-3p (MIRT469406)
- hsa-mir-646 (MIRT469407)
- hsa-mir-503-5p (MIRT469408)
- hsa-mir-6838-5p (MIRT469409)
- hsa-mir-497-5p (MIRT469410)
- hsa-mir-424-5p (MIRT469411)
- hsa-mir-195-5p (MIRT469412)
- hsa-mir-16-5p (MIRT469413)
- hsa-mir-15b-5p (MIRT469414)
- hsa-mir-15a-5p (MIRT469415)
- hsa-mir-4482-5p (MIRT469416)
- hsa-mir-3130-5p (MIRT469417)
- hsa-mir-1912 (MIRT469418)
- hsa-mir-1295b-5p (MIRT469419)
- hsa-mir-202-5p (MIRT469420)
- hsa-mir-337-3p (MIRT469421)
- hsa-mir-1260b (MIRT469422)
- hsa-mir-1260a (MIRT469423)
- hsa-mir-582-5p (MIRT469424)
- hsa-mir-101-3p (MIRT469425)
- hsa-mir-4326 (MIRT469426)
- hsa-mir-4433a-5p (MIRT469427)
- hsa-mir-1224-3p (MIRT469428)
- hsa-mir-5588-3p (MIRT469429)
- hsa-mir-4709-5p (MIRT469430)
- hsa-mir-548t-5p (MIRT469431)
- hsa-mir-548az-5p (MIRT469432)
- hsa-mir-548n (MIRT469433)
- hsa-mir-145-5p (MIRT469434)
- hsa-mir-4446-5p (MIRT469435)
- hsa-mir-7977 (MIRT469436)
- hsa-mir-767-5p (MIRT469437)
- hsa-mir-4729 (MIRT469438)
- hsa-mir-3065-3p (MIRT469439)
- hsa-mir-501-5p (MIRT469440)
- hsa-mir-135a-3p (MIRT469441)
- hsa-mir-6822-5p (MIRT469442)
- hsa-mir-6750-5p (MIRT469443)
- hsa-mir-5584-5p (MIRT469444)
- hsa-mir-500a-5p (MIRT469445)
- hsa-mir-3121-3p (MIRT469446)
- hsa-mir-29c-3p (MIRT469447)
- hsa-mir-29b-3p (MIRT469448)
- hsa-mir-29a-3p (MIRT469449)
- hsa-mir-3689d (MIRT469450)
- hsa-mir-7641 (MIRT469451)
- hsa-mir-6879-3p (MIRT469452)
- hsa-mir-3650 (MIRT469453)
- hsa-mir-3652 (MIRT469454)
- hsa-mir-4430 (MIRT469455)
- hsa-mir-122-5p (MIRT469456)
- hsa-mir-504-3p (MIRT469457)
- hsa-mir-3135b (MIRT469458)
- hsa-mir-4746-3p (MIRT469459)
- hsa-mir-4695-3p (MIRT469460)
- hsa-mir-6787-3p (MIRT469461)
- hsa-mir-500b-3p (MIRT469462)
- hsa-mir-2054 (MIRT554805)
- hsa-mir-527 (MIRT554806)
- hsa-mir-518a-5p (MIRT554807)
- hsa-mir-548aw (MIRT554808)
- hsa-mir-3686 (MIRT554809)
- hsa-mir-524-5p (MIRT554810)
- hsa-mir-520d-5p (MIRT554811)
- hsa-mir-4742-3p (MIRT554812)
- hsa-mir-92b-3p (MIRT554813)
- hsa-mir-92a-3p (MIRT554814)
- hsa-mir-367-3p (MIRT554815)
- hsa-mir-363-3p (MIRT554816)
- hsa-mir-32-5p (MIRT554817)
- hsa-mir-25-3p (MIRT554818)
- hsa-mir-4778-5p (MIRT554819)
- hsa-mir-380-3p (MIRT554820)
- hsa-mir-34c-3p (MIRT554821)
- hsa-mir-3163 (MIRT554822)
- hsa-mir-300 (MIRT554823)
- hsa-mir-381-3p (MIRT554824)
- hsa-mir-1264 (MIRT566053)
- hsa-mir-3680-3p (MIRT614448)
- hsa-mir-557 (MIRT614449)
- hsa-mir-507 (MIRT614450)
- hsa-mir-450b-5p (MIRT614451)
- hsa-mir-6516-5p (MIRT614452)
- hsa-mir-3678-3p (MIRT614453)
- hsa-mir-2467-3p (MIRT614454)
- hsa-mir-1273h-3p (MIRT614455)
- hsa-mir-4524a-3p (MIRT614456)
- hsa-mir-656-3p (MIRT614457)
- hsa-mir-329-5p (MIRT614458)
- hsa-mir-4524b-3p (MIRT614459)
- hsa-mir-3927-5p (MIRT622483)
- hsa-mir-4286 (MIRT622484)
- hsa-mir-136-3p (MIRT622485)
- hsa-mir-548c-3p (MIRT622486)
- hsa-mir-6509-5p (MIRT629818)
- hsa-mir-4713-5p (MIRT629819)
- hsa-mir-331-5p (MIRT629820)
- hsa-mir-2116-3p (MIRT629821)
- hsa-mir-532-3p (MIRT629822)
- hsa-mir-150-5p (MIRT629823)
- hsa-mir-4667-3p (MIRT629824)
- hsa-mir-1470 (MIRT629825)
- hsa-mir-6887-3p (MIRT629826)
- hsa-mir-6866-3p (MIRT629827)
- hsa-mir-188-5p (MIRT629828)
- hsa-mir-4678 (MIRT629829)
- hsa-mir-3064-3p (MIRT700210)
- hsa-mir-1227-3p (MIRT700211)
- hsa-mir-1250-3p (MIRT700212)
- hsa-mir-4289 (MIRT700213)
- hsa-mir-455-5p (MIRT700214)
- hsa-mir-382-3p (MIRT700215)
- hsa-mir-302b-5p (MIRT700216)
- hsa-mir-874-3p (MIRT700217)
- hsa-mir-6873-3p (MIRT700218)
- hsa-mir-593-3p (MIRT700219)
- hsa-mir-6895-3p (MIRT700220)
- hsa-mir-4261 (MIRT700221)
- hsa-mir-146b-3p (MIRT700222)
- hsa-mir-6799-3p (MIRT700223)
- hsa-mir-3173-5p (MIRT700224)
- hsa-mir-7976 (MIRT700225)
- hsa-mir-6817-3p (MIRT700226)
- hsa-mir-7110-3p (MIRT700227)
- hsa-mir-4716-5p (MIRT700228)
- hsa-mir-3688-3p (MIRT700229)
- hsa-mir-371b-3p (MIRT700230)
- hsa-mir-4802-3p (MIRT700231)
- hsa-mir-7-5p (MIRT732230)
- hsa-mir-1304-3p (MIRT762426)
- hsa-mir-215-3p (MIRT763846)
- hsa-mir-3664-5p (MIRT766520)
- hsa-mir-4639-3p (MIRT770551)
- hsa-mir-6773-3p (MIRT778716)
- hsa-mir-6794-3p (MIRT779339)
Transcription Factor Targets for REL Gene
miRNA Products
- Search ViGene Biosciences for REL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for REL
- Browse OriGene Inhibitory RNA Products For REL
- genomics-online: shRNA clones - Search results for available REL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for REL gene
Clone Products
- Sino Biological Human cDNA Clone for REL
- VectorBuilder custom plasmid, inducible vectors for REL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for REL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for REL
- genomics-online: cdna clones - Search results for available REL gene related products
- orf clones - Search results for available REL gene related products
- Applied Biological Materials Clones for REL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for REL
-
ViGene Biosciences adenoviral particle packaged cDNA for REL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for REL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for REL gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for REL Gene
Localization for REL Gene
Subcellular locations from UniProtKB/Swiss-Prot for REL Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IMP | 22065573 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS,IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for REL Gene
Pathways & Interactions for REL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response NFAT in immune response | ||
| 2 | IL-1 Family Signaling Pathways | ||
| 3 | Development EGFR signaling pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | Development A3 receptor signaling | ||
Pathways by source for REL Gene
2 Sino Biological pathways for REL Gene
10 BioSystems pathways for REL Gene
5 Reactome pathways for REL Gene
1 PharmGKB pathway for REL Gene
3 KEGG pathways for REL Gene
46 GeneGo (Thomson Reuters) pathways for REL Gene
7 R&D Systems pathways for REL Gene
3 Qiagen pathways for REL Gene
1 Cell Signaling Technology pathway for REL Gene
Interacting Proteins for REL Gene
Selected Interacting proteins:
ENSP00000295025
Q04864-REL_HUMAN
for REL Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0006954 | inflammatory response | IBA | -- |
Drugs & Compounds for REL Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for REL Gene
| Compound | Action | Cas Number |
|---|---|---|
| JSH-23 | NF-κB inhibitor | 749886-87-1 |
| QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Transcripts for REL Gene
mRNA/cDNA for REL Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (37) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for REL Gene
CRISPR Products
-
OriGene CRISPR knockouts for REL
- genomics-online: gRNA clones - Search results for available REL gene related products
- Applied Biological Materials CRISPR for REL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for REL
- GenScript: Design CRISPR guide RNA sequences for REL
miRNA Products
- Search ViGene Biosciences for REL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for REL
- Browse OriGene Inhibitory RNA Products For REL
- genomics-online: shRNA clones - Search results for available REL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for REL gene
Clone Products
- Sino Biological Human cDNA Clone for REL
- VectorBuilder custom plasmid, inducible vectors for REL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for REL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for REL
- genomics-online: cdna clones - Search results for available REL gene related products
- orf clones - Search results for available REL gene related products
- Applied Biological Materials Clones for REL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for REL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for REL Gene
This gene is overexpressed in Whole Blood (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (18.6) and Monocytes (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for REL Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of REL Gene:
RELSOURCE GeneReport for Unigene cluster for REL Gene:
Hs.631886Evidence on tissue expression from TISSUES for REL Gene
- Intestine(4.4)
- Blood(3.2)
- Spleen(3.2)
- Lymph node(2.6)
- Lung(2.5)
- Nervous system(2.5)
- Heart(2.4)
- Bone marrow(2.3)
- Liver(2.3)
- Kidney(2.2)
- Muscle(2.2)
- Skin(2.2)
Primer Products
-
OriGene qPCR primer pairs for REL
- genomics-online: primer clones - Search results for available REL gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for REL Gene
Orthologs for REL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | REL 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | REL 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | REL 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rel 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rel 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | REL 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | REL 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | REL 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | REL 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | rel-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rel 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dl 35 34 |
|
||
| Dif 35 34 |
|
||||
| Rel 35 |
|
|
|||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.770 33 |
|
- Species where no ortholog for REL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for REL Gene
Variants for REL Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000056584 | -- | 60,908,877(+) | G/A | intron_variant | |
| rs1000079605 | -- | 60,914,977(+) | G/A | intron_variant | |
| rs1000119842 | -- | 60,908,611(+) | A/G | intron_variant | |
| rs1000168436 | -- | 60,924,943(+) | A/C | 3_prime_UTR_variant | |
| rs1000343602 | -- | 60,919,805(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6908n54 | CNV | gain | 21841781 |
| nsv1127728 | CNV | deletion | 24896259 |
| nsv1134866 | CNV | deletion | 24896259 |
| nsv2749 | CNV | insertion | 18451855 |
| nsv524802 | CNV | loss | 19592680 |
| nsv834215 | CNV | loss | 17160897 |
| nsv953131 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.84;
34.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for REL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REL Gene
Disorders for REL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| reticuloendotheliosis |
|
|
| b-cell lymphomas |
|
|
| diffuse large b-cell lymphoma |
|
|
| lymphoma |
|
|
| chromosome 2p16.1-p15 deletion syndrome |
|
|
Search REL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for REL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for REL Gene
Publications for REL Gene
- Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. (PMID: 22170493) Ellinghaus E … Franke A (The Journal of investigative dermatology 2012) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population. (PMID: 19945995) Eyre S … Barton A (Annals of the rheumatic diseases 2010) 3 44 58
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58
- Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 44 58
Products for REL Gene
- R&D Systems Antibodies for REL (c-Rel)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for REL (c-Rel)
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- Custom Antibody ServicesOriGene Antibodies for REL
- Browse OriGene ELISA Kits
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For REL
- GenScript: Next-day shipping of latest version cDNA ORF clones for REL in any vector
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- GenScript: Design CRISPR guide RNA sequences for REL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for REL
- Browse Sino Biological Cell Lysates
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for REL
- Novus Biologicals proteins for REL
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for REL
- Abcam proteins for REL
- Find your target
- Browse Primary Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for REL
- Cyagen custom Knockout/knockin (KOKI) mouse models for REL
- VectorBuilder custom plasmid, inducible vectors for REL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for REL
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for REL
- antibodies-online: Search results for 1 available REL Antibodies ranked by validation data
- Compare Top REL Antibodies
- Quality Products:
- antibodies-online: Search results for available REL related products ranked by validation data
- antibodies-online: Search results for available REL related products ranked by validation data
- GeneTex REL antibody for REL
- Search GeneTex for Proteins for REL
- ViGene Biosciences adenoviral particle packaged cDNA for REL gene
- ViGene Biosciences lentiviral particle packaged cDNA for REL gene
- ViGene Biosciences ready-to-package AAV shRNAs for REL gene
- Search ViGene Biosciences for REL
- Santa Cruz Biotechnology (SCBT) Antibodies for REL
- Search Santa Cruz Biotechnology (SCBT) for REL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for REL
- Horizon Cell Lines for REL
- genomics-online: cdna clones - Search results for available REL gene related products
- orf clones - Search results for available REL gene related products
- genomics-online: gRNA clones - Search results for available REL gene related products
- genomics-online: primer clones - Search results for available REL gene related products
- genomics-online: shRNA clones - Search results for available REL gene related products
Sources for REL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems