Aliases for REG4 Gene

Aliases for REG4 Gene

  • Regenerating Family Member 4 2 3 5
  • GISP 2 3 4
  • RELP 2 3 4
  • Regenerating Islet-Derived Family, Member 4 2 3
  • Regenerating Islet-Derived Protein IV 3 4
  • Regenerating Islet-Derived Protein 4 3 4
  • Gastrointestinal Secretory Protein 3 4
  • Regenerating Gene Type IV 2 3
  • REG-Like Protein 3 4
  • REG-IV 2 3
  • Reg IV 3 4
  • REG-4 3 4
  • Gastrointestinal Secretory Protein 2
  • REG4 5

External Ids for REG4 Gene

Previous GeneCards Identifiers for REG4 Gene

  • GC01M119483
  • GC01M119683
  • GC01M120048
  • GC01M120138
  • GC01M120336
  • GC01M118195

Summaries for REG4 Gene

GeneCards Summary for REG4 Gene

REG4 (Regenerating Family Member 4) is a Protein Coding gene. Diseases associated with REG4 include Ulcerative Colitis and Urachus Cancer. Among its related pathways are Adhesion and Gastric cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is REG1B.

UniProtKB/Swiss-Prot Summary for REG4 Gene

  • Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

Gene Wiki entry for REG4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REG4 Gene

Genomics for REG4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for REG4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J119811 Promoter 0.3 EPDnew 250.7 +0.1 100 0.1 REG4 piR-56341-005 HSALNG0006518 HMGCS2
GH01J119782 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.3 +25.9 25914 6.9 CEBPA YY1 CEBPB ZNF341 ZNF521 CTBP1 FOXA2 RXRA SMAD4 CUX1 HSALNG0006515 WARS2-AS1 PHGDH REG4 HMGCS2 ADAM30 WARS2
GH01J119765 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 +43.8 43773 4.5 CEBPA JUND NFIC YY1 FOXA1 THAP11 FOXA2 KDM6A SMAD4 RXRA HMGCS2 HSD3BP5 ADAM30 REG4 ZNF697 HSALNG0006513 PHGDH
GH01J119789 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 +20.7 20698 2.4 YY1 FOXA2 RXRA ZBTB33 SOX5 JUND HNF4A FOXA1 RAD21 TFAP4 HMGCS2 REG4 ADAM30 HSALNG0006515 HSALNG0006517
GH01J119857 Enhancer 0.9 ENCODE 11.6 -47.6 -47561 2.7 NCOR1 IKZF1 JUND ZNF592 NFIC MBD2 TAF9B ZNF623 TAL1 ZNF316 WARS2-AS1 ADAM30 REG4 HMGCS2 WARS2 ZNF697 HSALNG0006522 piR-61534-004 PFN1P9 HSALNG0006520
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REG4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REG4

Top Transcription factor binding sites by QIAGEN in the REG4 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • Cart-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • Lhx3a
  • LHX3b

Genomic Locations for REG4 Gene

Latest Assembly
17,564 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
17,444 bases
Minus strand

(GRCh37/hg19 by Ensembl)
17,643 bases
Minus strand

Genomic View for REG4 Gene

Genes around REG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG4 Gene

Proteins for REG4 Gene

  • Protein details for REG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regenerating islet-derived protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8NER6
    • Q8NER7

    Protein attributes for REG4 Gene

    158 amino acids
    Molecular mass:
    18230 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM95599.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for REG4 Gene

    Alternative splice isoforms for REG4 Gene


neXtProt entry for REG4 Gene

Post-translational modifications for REG4 Gene

  • Glycosylation at Asn50
  • Modification sites at PhosphoSitePlus

Other Protein References for REG4 Gene

Antibodies for research

  • Abcam antibodies for REG4
  • Santa Cruz Biotechnology (SCBT) Antibodies for REG4

No data available for DME Specific Peptides for REG4 Gene

Domains & Families for REG4 Gene

Gene Families for REG4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for REG4 Gene

  • Pancreatitis-associated protein signature

Suggested Antigen Peptide Sequences for REG4 Gene

GenScript: Design optimal peptide antigens:
  • Regenerating islet-derived protein IV (REG4_HUMAN)
genes like me logo Genes that share domains with REG4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for REG4 Gene

Function for REG4 Gene

Molecular function for REG4 Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
UniProtKB/Swiss-Prot Induction:
Up-regulated by mucosal injury from active Crohn's disease or ulcerative colitis. Up-regulated in colorectal tumors. Up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach and duodenum.

Phenotypes From GWAS Catalog for REG4 Gene

Gene Ontology (GO) - Molecular Function for REG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 NOT calcium ion binding IDA 20692269
GO:0008201 heparin binding IDA 20692269
GO:0030246 carbohydrate binding IEA --
GO:0038023 signaling receptor activity IBA 21873635
GO:2001065 mannan binding IBA,IDA 20692269
genes like me logo Genes that share ontologies with REG4: view
genes like me logo Genes that share phenotypes with REG4: view

Animal Models for research

  • Taconic Biosciences Mouse Models for REG4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for REG4 Gene

Localization for REG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG4 gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for REG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 12819006
genes like me logo Genes that share ontologies with REG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for REG4 Gene

Pathways & Interactions for REG4 Gene

PathCards logo

SuperPathways for REG4 Gene

SuperPathway Contained pathways
1 Adhesion
2 Gastric cancer
genes like me logo Genes that share pathways with REG4: view

Pathways by source for REG4 Gene

1 KEGG pathway for REG4 Gene
1 Cell Signaling Technology pathway for REG4 Gene

Gene Ontology (GO) - Biological Process for REG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009617 response to bacterium IEA --
genes like me logo Genes that share ontologies with REG4: view

No data available for SIGNOR curated interactions for REG4 Gene

Drugs & Compounds for REG4 Gene

(1) Drugs for REG4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with REG4: view

Transcripts for REG4 Gene

mRNA/cDNA for REG4 Gene

9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG4

Alternative Splicing Database (ASD) splice patterns (SP) for REG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: -

Relevant External Links for REG4 Gene

GeneLoc Exon Structure for

Expression for REG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x32.8), Pancreas (x13.5), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for REG4 Gene

This gene is overexpressed in Fetal gut (52.2), Colon (7.1), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REG4 Gene

Protein tissue co-expression partners for REG4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REG4

SOURCE GeneReport for Unigene cluster for REG4 Gene:


mRNA Expression by UniProt/SwissProt for REG4 Gene:

Tissue specificity: Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.

Evidence on tissue expression from TISSUES for REG4 Gene

  • Intestine(4.9)
  • Stomach(4.3)
  • Pancreas(2.7)
  • Liver(2.3)
  • Nervous system(2.2)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with REG4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for REG4 Gene

Orthologs for REG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia REG4 29 30
  • 99.79 (n)
(Canis familiaris)
Mammalia LOC475818 29
  • 83.12 (n)
-- 30
  • 76 (a)
-- 30
  • 75 (a)
-- 30
  • 63 (a)
(Bos Taurus)
Mammalia REG4 29 30
  • 82.49 (n)
(Rattus norvegicus)
Mammalia Reg4 29
  • 77.71 (n)
(Mus musculus)
Mammalia Reg4 29 16 30
  • 77.35 (n)
(Monodelphis domestica)
Mammalia REG4 30
  • 67 (a)
(Gallus gallus)
Aves REG4 29
  • 51.75 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485485 29
  • 52.11 (n)
Species where no ortholog for REG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for REG4 Gene

Gene Tree for REG4 (if available)
Gene Tree for REG4 (if available)
Evolutionary constrained regions (ECRs) for REG4: view image
Alliance of Genome Resources:
Additional Orthologs for REG4

Paralogs for REG4 Gene

Paralogs for REG4 Gene

(9) SIMAP similar genes for REG4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with REG4: view

Variants for REG4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REG4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs34996202 Benign: not provided 119,798,503(-) T/Gp.Asn135His
NM_032044.4(REG4):c.403A>C (p.Asn135His)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for REG4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for REG4 Gene

Variant ID Type Subtype PubMed ID
nsv428201 CNV gain 18775914
nsv524681 CNV gain 19592680
nsv831215 CNV gain 17160897
nsv831226 CNV gain+loss 17160897

Variation tolerance for REG4 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG4 Gene

Disorders for REG4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for REG4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ulcerative colitis
  • left-sided ulcerative colitis
urachus cancer
  • malignant tumor of urachus
pseudomyxoma peritonei
  • mucinous ascites
  • cystoma
- elite association - COSMIC cancer census association via MalaCards
Search REG4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for REG4

genes like me logo Genes that share disorders with REG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG4 Gene

Publications for REG4 Gene

  1. Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. (PMID: 12455032) Violette S … Lesuffleur T (International journal of cancer 2003) 2 3 4 22
  2. RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. (PMID: 12819006) Kämäräinen M … Andersson LC (The American journal of pathology 2003) 3 4 22
  3. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. (PMID: 11311942) Hartupee JC … Dieckgraefe BK (Biochimica et biophysica acta 2001) 2 3 4
  4. Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. (PMID: 20692269) Ho MR … Chen C (Journal of molecular biology 2010) 3 4
  5. The role of Reg IV gene and its encoding product in gastric carcinogenesis. (PMID: 19740514) Zheng HC … Takano Y (Human pathology 2010) 3 22

Products for REG4 Gene

Sources for REG4 Gene