This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding ... See more...

Aliases for REG3G Gene

Aliases for REG3G Gene

  • Regenerating Family Member 3 Gamma 2 3 5
  • PAP1B 2 3 4
  • Regenerating Islet-Derived Protein III-Gamma 3 4
  • Regenerating Islet-Derived Protein 3-Gamma 3 4
  • Regenerating Islet-Derived 3 Gamma 2 3
  • Pancreatitis-Associated Protein 1B 3 4
  • Pancreatitis-Associated Protein IB 3 4
  • Reg III-Gamma 3 4
  • REG-3-Gamma 3 4
  • LPPM429 2 3
  • REG III 3 4
  • PAP IB 3 4
  • PAP-1B 3 4
  • UNQ429 2 3
  • Regenerating Gene III 3
  • REG-III 3
  • PAPIB 3
  • REG3G 5

External Ids for REG3G Gene

Previous GeneCards Identifiers for REG3G Gene

  • GC02P079165
  • GC02P079106

Summaries for REG3G Gene

Entrez Gene Summary for REG3G Gene

  • This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

GeneCards Summary for REG3G Gene

REG3G (Regenerating Family Member 3 Gamma) is a Protein Coding gene. Diseases associated with REG3G include Pancreatitis and Chemical Colitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3A.

UniProtKB/Swiss-Prot Summary for REG3G Gene

  • Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Gene Wiki entry for REG3G Gene

Additional gene information for REG3G Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REG3G Gene

Genomics for REG3G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for REG3G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J079025 Promoter 0.3 EPDnew 600.7 +0.1 65 0.1 REG3G lnc-REG1B-5 REG1B
GH02J079005 Enhancer 0.4 Ensembl 6 -20.3 -20263 0.4 RCOR1 YY1 CHD2 GATA2 REG3G ENSG00000286260
GH02J078977 Enhancer 1 Ensembl ENCODE 0.3 -47.2 -47218 3.3 CTCF BACH1 FOXA1 STAT3 RELA REST RAD21 TCF12 IRF2 IKZF2 REG3G ENSG00000286260
GH02J078967 Enhancer 0.9 Ensembl ENCODE 0.2 -58.2 -58163 0.2 GATAD2A SOX13 RXRB PBX2 CEBPA TCF7 ESR1 FOXA2 MAFF TEAD1 ENSG00000286260 REG3G
GH02J079041 Enhancer 0.4 Ensembl 0.4 +15.8 15836 0.6 CTCF RAD21 SMC3 lnc-REG1B-5 piR-41245-133 REG3G REG1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REG3G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REG3G

Top Transcription factor binding sites by QIAGEN in the REG3G gene promoter:
  • AML1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for REG3G Gene

Genomic Locations for REG3G Gene
chr2:79,025,664-79,028,505
(GRCh38/hg38)
Size:
2,842 bases
Orientation:
Plus strand
chr2:79,252,812-79,255,631
(GRCh37/hg19)
Size:
2,820 bases
Orientation:
Plus strand

Genomic View for REG3G Gene

Genes around REG3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG3G Gene

Proteins for REG3G Gene

  • Protein details for REG3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW15-REG3G_HUMAN
    Recommended name:
    Regenerating islet-derived protein 3-gamma
    Protein Accession:
    Q6UW15
    Secondary Accessions:
    • A8K980
    • D6W5J6
    • Q3SYE4
    • Q3SYE6
    • Q6FH18

    Protein attributes for REG3G Gene

    Size:
    175 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for REG3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for REG3G Gene

Post-translational modifications for REG3G Gene

  • Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Other Protein References for REG3G Gene

No data available for DME Specific Peptides for REG3G Gene

Domains & Families for REG3G Gene

Gene Families for REG3G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for REG3G Gene

InterPro:
Blocks:
  • Pancreatitis-associated protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for REG3G Gene

GenScript: Design optimal peptide antigens:
  • Regenerating islet-derived protein III-gamma (REG3G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UW15

UniProtKB/Swiss-Prot:

REG3G_HUMAN :
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
Domain:
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
genes like me logo Genes that share domains with REG3G: view

Function for REG3G Gene

Molecular function for REG3G Gene

UniProtKB/Swiss-Prot Function:
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Phenotypes From GWAS Catalog for REG3G Gene

Gene Ontology (GO) - Molecular Function for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0038023 signaling receptor activity IBA 21873635
GO:0042834 peptidoglycan binding IBA,IDA 16931762
GO:0070492 oligosaccharide binding IDA 16931762
genes like me logo Genes that share ontologies with REG3G: view
genes like me logo Genes that share phenotypes with REG3G: view

Animal Models for REG3G Gene

MGI Knock Outs for REG3G:
  • Reg3g Reg3g<tm1.1Lvh>
  • Reg3g Reg3g<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for REG3G

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG3G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for REG3G Gene

Localization for REG3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG3G Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG3G gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with REG3G: view

Pathways & Interactions for REG3G Gene

PathCards logo

SuperPathways for REG3G Gene

genes like me logo Genes that share pathways with REG3G: view

Pathways by source for REG3G Gene

3 Reactome pathways for REG3G Gene

Interacting Proteins for REG3G Gene

Gene Ontology (GO) - Biological Process for REG3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS --
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response IEA --
GO:0008284 positive regulation of cell proliferation IBA 21873635
GO:0010838 positive regulation of keratinocyte proliferation ISS --
genes like me logo Genes that share ontologies with REG3G: view

No data available for SIGNOR curated interactions for REG3G Gene

Drugs & Compounds for REG3G Gene

No Compound Related Data Available

Transcripts for REG3G Gene

mRNA/cDNA for REG3G Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG3G

Alternative Splicing Database (ASD) splice patterns (SP) for REG3G Gene

No ASD Table

Relevant External Links for REG3G Gene

GeneLoc Exon Structure for
REG3G

Expression for REG3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REG3G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG3G Gene

This gene is overexpressed in Pancreas (x49.7).

Protein differential expression in normal tissues from HIPED for REG3G Gene

This gene is overexpressed in Pancreas (36.7) and Islet of Langerhans (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REG3G Gene



Protein tissue co-expression partners for REG3G Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REG3G

SOURCE GeneReport for Unigene cluster for REG3G Gene:

Hs.447084

mRNA Expression by UniProt/SwissProt for REG3G Gene:

Q6UW15-REG3G_HUMAN
Tissue specificity: Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta.

Evidence on tissue expression from TISSUES for REG3G Gene

  • Pancreas(4.5)
  • Intestine(2.7)
  • Blood(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with REG3G: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for REG3G Gene

Orthologs for REG3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG3G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia REG3G 30 31
  • 98.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia REG3A 30 31 31
  • 85.9 (n)
ManyToMany
Cow
(Bos Taurus)
Mammalia REG3A 30
  • 81.71 (n)
PTP 31
  • 70 (a)
ManyToMany
REG3G 31
  • 65 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Reg3g 30
  • 75.34 (n)
Mouse
(Mus musculus)
Mammalia Reg3g 30 17 31
  • 74.95 (n)
ManyToMany
Reg3b 31
  • 68 (a)
ManyToMany
Reg3a 31
  • 65 (a)
ManyToMany
Reg3d 31
  • 51 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves REG4 31
  • 29 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for REG3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for REG3G Gene

ENSEMBL:
Gene Tree for REG3G (if available)
TreeFam:
Gene Tree for REG3G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for REG3G: view image

Paralogs for REG3G Gene

Paralogs for REG3G Gene

(5) SIMAP similar genes for REG3G Gene using alignment to 1 proteins:

  • REG3G_HUMAN
genes like me logo Genes that share paralogs with REG3G: view

Variants for REG3G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REG3G Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
731690 Benign: not provided 79,027,078(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
791859 Benign: not provided 79,027,823(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for REG3G Gene

Structural Variations from Database of Genomic Variants (DGV) for REG3G Gene

Variant ID Type Subtype PubMed ID
esv3584761 CNV loss 24956385
esv3892770 CNV gain 25118596
nsv522260 CNV gain 19592680

Variation tolerance for REG3G Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REG3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REG3G

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG3G Gene

Disorders for REG3G Gene

MalaCards: The human disease database

(2) MalaCards diseases for REG3G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatitis
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search REG3G in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with REG3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG3G Gene

Publications for REG3G Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. (PMID: 15777617) Laurine E … Verdier JM (Biochimica et biophysica acta 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4

Products for REG3G Gene

Sources for REG3G Gene