This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing ... See more...

Aliases for REG3A Gene

Aliases for REG3A Gene

  • Regenerating Family Member 3 Alpha 2 3 5
  • PAP1 2 3 4
  • HIP 2 3 4
  • Regenerating Islet-Derived Protein III-Alpha 3 4
  • Regenerating Islet-Derived Protein 3-Alpha 3 4
  • Hepatointestinal Pancreatic Protein 3 4
  • Regenerating Islet-Derived 3 Alpha 2 3
  • Pancreatitis-Associated Protein 1 3 4
  • Human Proislet Peptide 3 4
  • Reg III-Alpha 3 4
  • REG-3-Alpha 3 4
  • HIP/PAP 3 4
  • REG-III 2 3
  • PBCGF 2 3
  • REG3 2 3
  • PAP 3 4
  • Hepatocarcinoma-Intestine-Pancreas 3
  • Pancreatic Beta Cell Growth Factor 3
  • Proliferation-Inducing Protein 34 3
  • Proliferation-Inducing Protein 42 3
  • Pancreatitis-Associated Protein 2
  • PAP Homologous Protein 3
  • INGAP 3
  • PAP-H 3
  • REG3A 5

External Ids for REG3A Gene

Previous HGNC Symbols for REG3A Gene

  • PAP

Previous GeneCards Identifiers for REG3A Gene

  • GC02M079296
  • GC02M079384
  • GC02M079119

Summaries for REG3A Gene

Entrez Gene Summary for REG3A Gene

  • This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

GeneCards Summary for REG3A Gene

REG3A (Regenerating Family Member 3 Alpha) is a Protein Coding gene. Diseases associated with REG3A include Pancreatitis and Acute Pancreatitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is REG3G.

UniProtKB/Swiss-Prot Summary for REG3A Gene

  • Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

Gene Wiki entry for REG3A Gene

Additional gene information for REG3A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for REG3A Gene

Genomics for REG3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for REG3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J079159 Promoter 0.3 EPDnew 600.7 0.0 -20 0.1 ENSG00000224879 REG3A lnc-REG3A-2 piR-33905-040 CTNNA2
GH02J079200 Enhancer 0.4 Ensembl 11.1 -41.3 -41347 0.2 FOXA1 FOXA2 NANOG REG3A ENSG00000224879 HSALNG0016283 CTNNA2 LOC107985902
GH02J079201 Enhancer 0.2 Ensembl 11.2 -43.0 -43048 2.8 REG3A ENSG00000224879 CTNNA2 HSALNG0016283 LOC107985902
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around REG3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for REG3A

Top Transcription factor binding sites by QIAGEN in the REG3A gene promoter:
  • FOXJ2 (long isoform)
  • LCR-F1
  • STAT3

Genomic Locations for REG3A Gene

Genomic Locations for REG3A Gene
chr2:79,157,003-79,159,753
(GRCh38/hg38)
Size:
2,751 bases
Orientation:
Minus strand
chr2:79,384,132-79,386,880
(GRCh37/hg19)
Size:
2,749 bases
Orientation:
Minus strand

Genomic View for REG3A Gene

Genes around REG3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG3A Gene

Proteins for REG3A Gene

  • Protein details for REG3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06141-REG3A_HUMAN
    Recommended name:
    Regenerating islet-derived protein 3-alpha
    Protein Accession:
    Q06141

    Protein attributes for REG3A Gene

    Size:
    175 amino acids
    Molecular mass:
    19395 Da
    Quaternary structure:
    • Interacts with EXTL3.

    Three dimensional structures from OCA and Proteopedia for REG3A Gene

neXtProt entry for REG3A Gene

Post-translational modifications for REG3A Gene

  • Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Other Protein References for REG3A Gene

No data available for DME Specific Peptides for REG3A Gene

Domains & Families for REG3A Gene

Gene Families for REG3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for REG3A Gene

InterPro:
Blocks:
  • Pancreatitis-associated protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for REG3A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA (Q53S56_HUMAN)
  • Regenerating islet-derived protein III-alpha (REG3A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06141

UniProtKB/Swiss-Prot:

REG3A_HUMAN :
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
Domain:
  • The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
genes like me logo Genes that share domains with REG3A: view

Function for REG3A Gene

Molecular function for REG3A Gene

UniProtKB/Swiss-Prot Function:
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
UniProtKB/Swiss-Prot Induction:
Appears in pancreatic juice after induction of pancreatic inflammation.

Phenotypes From GWAS Catalog for REG3A Gene

Gene Ontology (GO) - Molecular Function for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding TAS 1325291
GO:0038023 signaling receptor activity IBA 21873635
GO:0042802 identical protein binding IPI 24256734
GO:0042834 peptidoglycan binding IBA 21873635
genes like me logo Genes that share ontologies with REG3A: view
genes like me logo Genes that share phenotypes with REG3A: view

Animal Models for REG3A Gene

MGI Knock Outs for REG3A:

Animal Model Products

  • Taconic Biosciences Mouse Models for REG3A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG3A

Clone Products

  • Addgene plasmids for REG3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for REG3A Gene

Localization for REG3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG3A Gene

Secreted. Note=Found in the apical region of pancreatic acinar cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG3A gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0005737 cytoplasm TAS 8997243
genes like me logo Genes that share ontologies with REG3A: view

Pathways & Interactions for REG3A Gene

PathCards logo

SuperPathways for REG3A Gene

genes like me logo Genes that share pathways with REG3A: view

Pathways by source for REG3A Gene

3 Reactome pathways for REG3A Gene

Gene Ontology (GO) - Biological Process for REG3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS 8997243
GO:0008284 positive regulation of cell proliferation IBA 21873635
GO:0010838 positive regulation of keratinocyte proliferation ISS --
genes like me logo Genes that share ontologies with REG3A: view

No data available for SIGNOR curated interactions for REG3A Gene

Drugs & Compounds for REG3A Gene

(3) Drugs for REG3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for REG3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REG3A: view

Transcripts for REG3A Gene

mRNA/cDNA for REG3A Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for REG3A

Clone Products

  • Addgene plasmids for REG3A

Alternative Splicing Database (ASD) splice patterns (SP) for REG3A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: -
SP3: -

Relevant External Links for REG3A Gene

GeneLoc Exon Structure for
REG3A

Expression for REG3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for REG3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG3A Gene

This gene is overexpressed in Pancreas (x38.1) and Small Intestine - Terminal Ileum (x14.4).

Protein differential expression in normal tissues from HIPED for REG3A Gene

This gene is overexpressed in Islet of Langerhans (23.3), Pancreas (20.3), Pancreatic juice (15.5), and Cardia (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for REG3A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for REG3A

SOURCE GeneReport for Unigene cluster for REG3A Gene:

Hs.567312

mRNA Expression by UniProt/SwissProt for REG3A Gene:

Q06141-REG3A_HUMAN
Tissue specificity: Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.

Evidence on tissue expression from TISSUES for REG3A Gene

  • Intestine(4.9)
  • Pancreas(4.8)
  • Stomach(4.7)
  • Blood(4.4)
  • Liver(4.4)
  • Nervous system(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with REG3A: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for REG3A Gene

Orthologs for REG3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia REG3A 30 31
  • 99.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Reg3b 30 17 31
  • 75.1 (n)
ManyToMany
Reg3g 31
  • 66 (a)
ManyToMany
Reg3a 31
  • 61 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia REG3A 31 31
  • 74 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Reg3b 30
  • 72.99 (n)
Cow
(Bos Taurus)
Mammalia PTP 31
  • 70 (a)
ManyToMany
REG3G 31
  • 63 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves REG4 31
  • 30 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for REG3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for REG3A Gene

ENSEMBL:
Gene Tree for REG3A (if available)
TreeFam:
Gene Tree for REG3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for REG3A: view image

Paralogs for REG3A Gene

Paralogs for REG3A Gene

(7) SIMAP similar genes for REG3A Gene using alignment to 2 proteins:

  • REG3A_HUMAN
  • L8E7R5_HUMAN
genes like me logo Genes that share paralogs with REG3A: view

Variants for REG3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for REG3A Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
723766 Likely Benign: not provided 79,159,400(-) C/A SYNONYMOUS_VARIANT
728936 Likely Benign: not provided 79,157,247(-) A/G SYNONYMOUS_VARIANT
747179 Likely Benign: not provided 79,159,375(-) A/T MISSENSE_VARIANT
769260 Likely Benign: not provided 79,158,660(-) T/C SYNONYMOUS_VARIANT
783978 Benign: not provided 79,157,582(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for REG3A Gene

Structural Variations from Database of Genomic Variants (DGV) for REG3A Gene

Variant ID Type Subtype PubMed ID
dgv1135e212 CNV loss 25503493
esv3584761 CNV loss 24956385
esv3892770 CNV gain 25118596
nsv522260 CNV gain 19592680

Variation tolerance for REG3A Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REG3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REG3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG3A Gene

Disorders for REG3A Gene

MalaCards: The human disease database

(7) MalaCards diseases for REG3A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis
acute pancreatitis
  • acute necrotizing pancreatitis
alcoholic pancreatitis
  • pancreatitis alcoholic
cystic fibrosis
  • cf
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search REG3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for REG3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with REG3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG3A Gene

Publications for REG3A Gene

  1. Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. (PMID: 8188210) Dusetti NJ … Iovanna JL (Genomics 1994) 2 3 4 23
  2. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. (PMID: 8076648) Lasserre C … Brechot C (European journal of biochemistry 1994) 3 4 23
  3. Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). (PMID: 7679928) Itoh T … Teraoka H (Biochimica et biophysica acta 1993) 3 4 23
  4. Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. (PMID: 1469087) Orelle B … Iovanna JL (The Journal of clinical investigation 1992) 3 4 23
  5. A novel gene (HIP) activated in human primary liver cancer. (PMID: 1325291) Lasserre C … Bréchot C (Cancer research 1992) 3 4 23

Products for REG3A Gene

Sources for REG3A Gene