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Aliases for REG1A Gene

Aliases for REG1A Gene

  • Regenerating Family Member 1 Alpha 2 3 5
  • Pancreatic Thread Protein 2 3 4
  • Regenerating Islet-Derived Protein 1-Alpha 3 4
  • Islet Of Langerhans Regenerating Protein 3 4
  • Islet Cells Regeneration Factor 3 4
  • Regenerating Protein I Alpha 3 4
  • Pancreatic Stone Protein 2 4
  • REG-1-Alpha 3 4
  • PSPS1 3 4
  • ICRF 3 4
  • PSPS 3 4
  • PSP 3 4
  • PTP 3 4
  • REG 3 4
  • Regenerating Islet-Derived 1 Alpha (Pancreatic Stone Protein, Pancreatic Thread Protein) 2
  • Pancreatic Stone Protein, Secretory 3
  • Lithostathine-1-Alpha 3
  • Protein-X 3
  • P19 3

External Ids for REG1A Gene

Previous HGNC Symbols for REG1A Gene

  • REG

Previous GeneCards Identifiers for REG1A Gene

  • GC02P079485
  • GC02P079305
  • GC02P079322
  • GC02P079259
  • GC02P079201
  • GC02P079082
  • GC02P079347

Summaries for REG1A Gene

Entrez Gene Summary for REG1A Gene

  • This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

GeneCards Summary for REG1A Gene

REG1A (Regenerating Family Member 1 Alpha) is a Protein Coding gene. Diseases associated with REG1A include Pancreatitis and Acinar Cell Carcinoma. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and Type II interferon signaling (IFNG). Gene Ontology (GO) annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is REG1B.

UniProtKB/Swiss-Prot for REG1A Gene

  • Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Gene Wiki entry for REG1A Gene

Additional gene information for REG1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REG1A Gene

Genomics for REG1A Gene

GeneHancer (GH) Regulatory Elements for REG1A Gene

Promoters and enhancers for REG1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I079121 Promoter/Enhancer 0.7 EPDnew ENCODE 550.8 0.0 -4 0.3 REG1A GC02P079100
GH02I079120 Promoter 0.5 EPDnew 550.8 +0.4 408 0.1 REG1A REG1CP GC02P079100
GH02I079098 Enhancer 0.2 ENCODE 12.2 -21.0 -21032 0.7 PIR50017 GC02P079100 REG1A
GH02I079084 Enhancer 0.2 ENCODE 11.1 -36.2 -36212 0.2 REG1A REG1B REG3G
GH02I079083 Enhancer 0.2 ENCODE 11.1 -36.6 -36572 0.2 REG1A REG1B REG3G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REG1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the REG1A gene promoter:

Genomic Locations for REG1A Gene

Genomic Locations for REG1A Gene
chr2:79,120,362-79,123,419
(GRCh38/hg38)
Size:
3,058 bases
Orientation:
Plus strand
chr2:79,347,488-79,350,545
(GRCh37/hg19)

Genomic View for REG1A Gene

Genes around REG1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REG1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REG1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REG1A Gene

Proteins for REG1A Gene

  • Protein details for REG1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05451-REG1A_HUMAN
    Recommended name:
    Lithostathine-1-alpha
    Protein Accession:
    P05451
    Secondary Accessions:
    • P11379
    • Q4ZG28

    Protein attributes for REG1A Gene

    Size:
    166 amino acids
    Molecular mass:
    18731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for REG1A Gene

neXtProt entry for REG1A Gene

Post-translational modifications for REG1A Gene

  • The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.
  • Glycosylation at isoforms=27

Other Protein References for REG1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for REG1A Gene

Domains & Families for REG1A Gene

Gene Families for REG1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with REG1A: view

No data available for UniProtKB/Swiss-Prot for REG1A Gene

Function for REG1A Gene

Molecular function for REG1A Gene

GENATLAS Biochemistry:
regenerating gene,rat islet-derived homolog 1 alpha,expressed in kidney,stomach,pancreas,involved in beta cells proliferation
UniProtKB/Swiss-Prot Function:
Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Gene Ontology (GO) - Molecular Function for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IDA 10526060
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with REG1A: view
genes like me logo Genes that share phenotypes with REG1A: view

Animal Models for REG1A Gene

MGI Knock Outs for REG1A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REG1A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for REG1A Gene

Localization for REG1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for REG1A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REG1A gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with REG1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for REG1A Gene

Pathways & Interactions for REG1A Gene

genes like me logo Genes that share pathways with REG1A: view

Pathways by source for REG1A Gene

2 BioSystems pathways for REG1A Gene

Gene Ontology (GO) - Biological Process for REG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation TAS 2332435
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with REG1A: view

No data available for SIGNOR curated interactions for REG1A Gene

Drugs & Compounds for REG1A Gene

(11) Drugs for REG1A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
phosphoserine Experimental Pharma Target 0
N-acetyl-alpha-neuraminic acid Experimental Pharma Target 0

(1) Additional Compounds for REG1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with REG1A: view

Transcripts for REG1A Gene

Unigene Clusters for REG1A Gene

Regenerating islet-derived 1 alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for REG1A

Alternative Splicing Database (ASD) splice patterns (SP) for REG1A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - - - -

Relevant External Links for REG1A Gene

GeneLoc Exon Structure for
REG1A
ECgene alternative splicing isoforms for
REG1A

Expression for REG1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REG1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for REG1A Gene

This gene is overexpressed in Pancreas (x49.8).

Protein differential expression in normal tissues from HIPED for REG1A Gene

This gene is overexpressed in Islet of Langerhans (44.0) and Pancreatic juice (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REG1A Gene



Protein tissue co-expression partners for REG1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of REG1A Gene:

REG1A

SOURCE GeneReport for Unigene cluster for REG1A Gene:

Hs.49407

mRNA Expression by UniProt/SwissProt for REG1A Gene:

P05451-REG1A_HUMAN
Tissue specificity: In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.

Evidence on tissue expression from TISSUES for REG1A Gene

  • Pancreas(5)
  • Intestine(4.3)
  • Stomach(4.2)
  • Nervous system(2.8)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for REG1A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • nervous
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
Thorax:
  • heart
Abdomen:
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
genes like me logo Genes that share expression patterns with REG1A: view

Primer Products

Orthologs for REG1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for REG1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REG1A 33 34
  • 99.6 (n)
mouse
(Mus musculus)
Mammalia Reg1 33 16 34
  • 79.3 (n)
Reg2 34
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Reg1a 33
  • 76.94 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
chicken
(Gallus gallus)
Aves REG4 34
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
Species where no ortholog for REG1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for REG1A Gene

ENSEMBL:
Gene Tree for REG1A (if available)
TreeFam:
Gene Tree for REG1A (if available)

Paralogs for REG1A Gene

Paralogs for REG1A Gene

genes like me logo Genes that share paralogs with REG1A: view

Variants for REG1A Gene

Sequence variations from dbSNP and Humsavar for REG1A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000656326 -- 79,122,522(+) T/C intron_variant
rs1001324470 -- 79,120,074(+) A/G upstream_transcript_variant
rs1001969984 -- 79,119,086(+) C/A upstream_transcript_variant
rs1002022139 -- 79,119,358(+) C/T upstream_transcript_variant
rs1002645541 -- 79,121,460(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for REG1A Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV gain 19592680
nsv2796 CNV deletion 18451855
esv3892770 CNV gain 25118596
esv3584761 CNV loss 24956385

Variation tolerance for REG1A Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REG1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
REG1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REG1A Gene

Disorders for REG1A Gene

MalaCards: The human disease database

(7) MalaCards diseases for REG1A Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search REG1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for REG1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with REG1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for REG1A Gene

Publications for REG1A Gene

  1. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. (PMID: 2332435) Watanabe T … Okamoto H (The Journal of biological chemistry 1990) 2 3 4 22 58
  2. Human regeneration protein/lithostathine genes map to chromosome 2p12. (PMID: 8333731) Gharib B … Berge-lefranc JL (Annals of human genetics 1993) 2 3 22 58
  3. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. (PMID: 2394826) de la Monte SM … Wands JR (The Journal of clinical investigation 1990) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. (PMID: 20065946) Sekikawa A … Fujimori T (Laboratory investigation; a journal of technical methods and pathology 2010) 3 22 58

Products for REG1A Gene

Sources for REG1A Gene

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