RECQL5 Gene (Protein Coding)

RecQ Like Helicase 5

GC17M075626
GIFtS:
39
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] See more...

Aliases for RECQL5 Gene

Aliases for RECQL5 Gene

  • RecQ Like Helicase 5 2 3 5
  • DNA Helicase, RecQ-Like Type 5 3 4
  • ATP-Dependent DNA Helicase Q5 3 4
  • RecQ Protein-Like 5 3 4
  • RECQ5 3 4
  • RecQ5 2 4
  • RecQ Helicase-Like 5 3
  • RecQ Protein 5 2
  • EC 3.6.4.12 4
  • FLJ90603 2
  • EC 3.6.1 51
  • RECQL5 5

External Ids for RECQL5 Gene

Previous GeneCards Identifiers for RECQL5 Gene

  • GC17M073593
  • GC17M076648
  • GC17M074087
  • GC17M074220
  • GC17M071134
  • GC17M073622
  • GC17M069046

Summaries for RECQL5 Gene

Entrez Gene Summary for RECQL5 Gene

  • The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for RECQL5 Gene

RECQL5 (RecQ Like Helicase 5) is a Protein Coding gene. Diseases associated with RECQL5 include Rothmund-Thomson Syndrome, Type 2 and Bloom Syndrome. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is BLM.

UniProtKB/Swiss-Prot Summary for RECQL5 Gene

  • Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.

Gene Wiki entry for RECQL5 Gene

Additional gene information for RECQL5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RECQL5 Gene

Genomics for RECQL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RECQL5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RECQL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RECQL5

Top Transcription factor binding sites by QIAGEN in the RECQL5 gene promoter:
  • AML1a
  • CREB
  • HTF
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for RECQL5 Gene

Genomic Locations for RECQL5 Gene
chr17:75,626,845-75,667,202
(GRCh38/hg38)
Size:
40,358 bases
Orientation:
Minus strand
chr17:73,622,925-73,663,269
(GRCh37/hg19)
Size:
40,345 bases
Orientation:
Minus strand

Genomic View for RECQL5 Gene

Genes around RECQL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RECQL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RECQL5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RECQL5 Gene

Proteins for RECQL5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RECQL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94762-RECQ5_HUMAN
    Recommended name:
    ATP-dependent DNA helicase Q5
    Protein Accession:
    O94762
    Secondary Accessions:
    • Q6P4G0
    • Q9H0B1
    • Q9P1W7
    • Q9UNC8

    Protein attributes for RECQL5 Gene

    Size:
    991 amino acids
    Molecular mass:
    108858 Da
    Quaternary structure:
    • Monomer. Interacts with TOP2A, TOP3A and TOP3B. Isoform beta interacts with RNA polymerase II subunit POLR2A. Identified in a complex with the RNA polymerase II core bound to DNA. Isoform beta interacts with RAD51.

    Three dimensional structures from OCA and Proteopedia for RECQL5 Gene

    Alternative splice isoforms for RECQL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RECQL5 Gene

Protein Expression for RECQL5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for RECQL5 Gene

O94762:
  • GKSLCYQ
  • SQWGHDFR
  • LVVDEAH
  • YYQESGRAGRD

Post-translational modifications for RECQL5 Gene

  • Ubiquitination at Lys22
  • Modification sites at PhosphoSitePlus

Other Protein References for RECQL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RECQL5 Gene

Gene Families for RECQL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RECQL5 Gene

InterPro:
Blocks:
  • ATP-dependent helicase, DEAH-box
ProtoNet:

Suggested Antigen Peptide Sequences for RECQL5 Gene

GenScript: Design optimal peptide antigens:
  • RECQL5 protein (A5YM55_HUMAN)
  • cDNA FLJ61700, highly similar to ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (B7Z8Y7_HUMAN)
  • RecQ protein-like 5, isoform CRA_b (Q6FIC9_HUMAN)
  • RecQ protein-like 5, isoform CRA_c (Q6P4G0_HUMAN)
  • RECQL5 protein (Q9BW80_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94762

UniProtKB/Swiss-Prot:

RECQ5_HUMAN :
  • Belongs to the helicase family. RecQ subfamily.
Family:
  • Belongs to the helicase family. RecQ subfamily.
genes like me logo Genes that share domains with RECQL5: view

Function for RECQL5 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
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Molecular function for RECQL5 Gene

UniProtKB/Swiss-Prot Function:
Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:22013166};.
GENATLAS Biochemistry:
DNA helicase ATP dependent,homologous to E coli RecQ,ubiquitously expressed,upregulated at the G2-M stage of the cell cycle,RecQl family

Enzyme Numbers (IUBMB) for RECQL5 Gene

Phenotypes From GWAS Catalog for RECQL5 Gene

Gene Ontology (GO) - Molecular Function for RECQL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000993 RNA polymerase II complex binding IDA 23748380
GO:0003676 nucleic acid binding IEA --
GO:0003678 DNA helicase activity TAS,NAS 10710432
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with RECQL5: view
genes like me logo Genes that share phenotypes with RECQL5: view

Animal Models for RECQL5 Gene

MGI Knock Outs for RECQL5:

Animal Model Products

  • Taconic Biosciences Mouse Models for RECQL5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RECQL5

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RECQL5 Gene

Localization for RECQL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RECQL5 Gene

[Isoform Beta]: Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. {ECO:0000269 PubMed:20643585, ECO:0000269 PubMed:22013166, ECO:0000269 PubMed:22973052, ECO:0000269 PubMed:23715498}.
[Isoform Alpha]: Cytoplasm.
[Isoform Gamma]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RECQL5 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RECQL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 22013166
GO:0005654 nucleoplasm NAS 10710432
GO:0005694 chromosome IBA 21873635
GO:0005737 cytoplasm IBA,NAS 10710432
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RECQL5: view

Pathways & Interactions for RECQL5 Gene

PathCards logo

SuperPathways for RECQL5 Gene

SuperPathway Contained pathways
1 DNA Damage
DNA Damage
-
genes like me logo Genes that share pathways with RECQL5: view

Pathways by source for RECQL5 Gene

1 Cell Signaling Technology pathway for RECQL5 Gene

Gene Ontology (GO) - Biological Process for RECQL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 22013166
GO:0000724 double-strand break repair via homologous recombination IBA 21873635
GO:0006259 DNA metabolic process NAS 10710432
GO:0006260 DNA replication IMP 22013166
GO:0006268 DNA unwinding involved in DNA replication IBA 21873635
genes like me logo Genes that share ontologies with RECQL5: view

No data available for SIGNOR curated interactions for RECQL5 Gene

Drugs & Compounds for RECQL5 Gene

Products:

  1. Drug

(3) Drugs for RECQL5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for RECQL5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with RECQL5: view

Transcripts for RECQL5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RECQL5 Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RECQL5

Alternative Splicing Database (ASD) splice patterns (SP) for RECQL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - - - - - - - - - -
SP8:
SP9:
SP10: - -
SP11: -
SP12: - -
SP13:

ExUns: 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RECQL5 Gene

GeneLoc Exon Structure for
RECQL5

Expression for RECQL5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RECQL5 Gene

mRNA expression in normal human tissues for RECQL5 Gene
mRNA expression by GTEx for RECQL5 GenemRNA expression by BioGPS for RECQL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RECQL5 Gene

This gene is overexpressed in Lung (29.8), Saliva (11.4), and Bone marrow stromal cell (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RECQL5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RECQL5

SOURCE GeneReport for Unigene cluster for RECQL5 Gene:

Hs.632229

mRNA Expression by UniProt/SwissProt for RECQL5 Gene:

O94762-RECQ5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RECQL5 Gene

  • Intestine(4.4)
  • Liver(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with RECQL5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RECQL5 Gene

Orthologs for RECQL5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RECQL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RECQL5 30 31
  • 99.16 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RECQL5 30 31
  • 87.02 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RECQL5 30 31
  • 85.52 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Recql5 30 17 31
  • 82.2 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Recql5 30
  • 81.38 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia RECQL5 31
  • 77 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RECQL5 31
  • 67 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RECQL5 30 31
  • 64.56 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RECQL5 31
  • 54 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia recql5 30
  • 62.11 (n)
Zebrafish
(Danio rerio)
 Actinopterygii recql5 30
  • 56.92 (n)
recql5l 31
  • 49 (a)
 OneToOne
Dr.28571 30
Fruit Fly
(Drosophila melanogaster)
 Insecta RecQ5 31
  • 33 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea rcq-5 30 31
  • 46.59 (n)
 OneToOne
wrn-1 32
  • 36 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SGS1 31
  • 13 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 53 (a)
 OneToOne
Species where no ortholog for RECQL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RECQL5 Gene

ENSEMBL:
Gene Tree for RECQL5 (if available)
TreeFam:
Gene Tree for RECQL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RECQL5: view image

Paralogs for RECQL5 Gene

Paralogs for RECQL5 Gene

(2) SIMAP similar genes for RECQL5 Gene using alignment to 11 proteins:

  • RECQ5_HUMAN
  • A5YM55_HUMAN
  • J3KRM6_HUMAN
  • J3KS37_HUMAN
  • J3KSL7_HUMAN
  • J3KSV9_HUMAN
  • J3KTQ2_HUMAN
  • J3QLU0_HUMAN
  • Q6FIC9_HUMAN
  • Q6P4G0_HUMAN
  • Q9BW80_HUMAN
genes like me logo Genes that share paralogs with RECQL5: view

Variants for RECQL5 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RECQL5 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
708597 Benign: not provided 75,629,130(-) C/T MISSENSE_VARIANT
708598 Benign: not provided 75,629,151(-) G/A MISSENSE_VARIANT
708609 Benign: not provided 75,662,971(-) T/C SYNONYMOUS_VARIANT
709680 Likely Benign: not provided 75,630,657(-) C/T SYNONYMOUS_VARIANT
714863 Benign: not provided 75,628,979(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for RECQL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for RECQL5 Gene

Variant ID Type Subtype PubMed ID
nsv470603 CNV loss 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv576032 CNV gain 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for RECQL5 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.99; 89.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RECQL5 Gene

Human Gene Mutation Database (HGMD)
RECQL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RECQL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RECQL5 Gene

Disorders for RECQL5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RECQL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rothmund-thomson syndrome, type 2
  • rts2
bloom syndrome
  • bls
werner syndrome
  • wrn
rapadilino syndrome
  • absent thumbs, dislocated joints, long face with narrow palpebral fissures, long slender nose, arched palate
baller-gerold syndrome
  • bgs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RECQL5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RECQL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RECQL5 Gene

Publications for RECQL5 Gene

  1. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. (PMID: 9878247) Kitao S … Shimamoto A (Genomics 1998) 2 3 4 23
  2. RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. (PMID: 20231364) Islam MN … Wang W (Molecular and cellular biology 2010) 3 4 23
  3. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. (PMID: 10710432) Shimamoto A … Furuichi Y (Nucleic acids research 2000) 3 4 23
  4. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. (PMID: 10471747) Sekelsky JJ … Hawley RS (Nucleic acids research 1999) 3 4 23
  5. Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5. (PMID: 23748380) Kassube SA … Nogales E (Nature structural & molecular biology 2013) 3 4

ExternalLinks

View latest publications for RECQL5 gene in Mastermind

Products for RECQL5 Gene

Sources for RECQL5 Gene