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The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs) is a Protein Coding gene. Diseases associated with RECK include Ovarian Cancer and Middle Ear Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Angiogenesis (CST). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004866 | endopeptidase inhibitor activity | IDA | 9789069 |
GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 21255571 |
GO:0008191 | metalloendopeptidase inhibitor activity | TAS,IDA | 18194466 |
GO:0017147 | Wnt-protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | TAS | 9789069 |
GO:0031225 | anchored component of membrane | IEA | -- |
GO:1990909 | Wnt signalosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Angiogenesis (CST) | ||
3 | MicroRNAs in cancer | ||
4 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
5 | Post-translational modification- synthesis of GPI-anchored proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001944 | vasculature development | IEA,IBA | 21873635 |
GO:0001955 | blood vessel maturation | IBA | 21873635 |
GO:0007566 | embryo implantation | IEA | -- |
GO:0010466 | negative regulation of peptidase activity | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RECK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RECK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RECK 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RECK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RECK 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Reck 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Reck 30 |
|
||
Chicken (Gallus gallus) |
Aves | RECK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RECK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | reck 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | RECK 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Reck 30 31 |
|
OneToOne | |
CG5392 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010646 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
707848 | Benign: not provided | 36,102,091(+) | A/C | INTRON_VARIANT | |
729613 | Likely Benign: not provided | 36,102,099(+) | A/G | MISSENSE_VARIANT | |
768292 | Benign: not provided | 36,122,958(+) | C/T | SYNONYMOUS_VARIANT | |
770385 | Benign: not provided | 36,058,819(+) | T/G | INTRON_VARIANT | |
rs16932912 | - | p.Val275Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|
|
middle ear squamous cell carcinoma |
|
|
middle ear carcinoma |
|
|
ocular albinism |
|
|
lactose intolerance |
|