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The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion a... See more...
Aliases for RECK Gene
Aliases for RECK Gene
- Reversion Inducing Cysteine Rich Protein With Kazal Motifs 2 3 5
- Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs 3 4
- Suppressor Of Tumorigenicity 15 Protein 3 4
- HRECK 2 4
- ST15 3 4
- Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
- Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs) 3
- Membrane-Anchored Glycoprotein (Metastasis And Invasion) 3
- RECK 5
External Ids for RECK Gene
- HGNC: 11345
- NCBI Entrez Gene: 8434
- Ensembl: ENSG00000122707
- OMIM®: 605227
- UniProtKB/Swiss-Prot: O95980
Previous HGNC Symbols for RECK Gene
- ST15
Previous GeneCards Identifiers for RECK Gene
- GC09P036349
- GC09P036206
- GC09P036026
- GC09P035990
Summaries for RECK Gene
-
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for RECK Gene
RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs) is a Protein Coding gene. Diseases associated with RECK include Ovarian Cancer and Middle Ear Squamous Cell Carcinoma. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
UniProtKB/Swiss-Prot Summary for RECK Gene
-
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).
Additional gene information for RECK Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RECK Gene
Genomics for RECK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RECK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RECK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RECK
- Top Transcription factor binding sites by QIAGEN in the RECK gene promoter:
-
- ATF6
- c-Myc
- C/EBPalpha
- E47
- FOXO4
- ITF-2
- Max
- MyoD
- Tal-1beta
Genomic Locations for RECK Gene
Latest Assembly
- chr9:36,036,905-36,124,455
- (GRCh38/hg38)
- Size:
- 87,551 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:36,036,910-36,124,452
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 87,543 bases
- Orientation:
- Plus strand
Genomic View for RECK Gene
Genes around RECK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.3 by HGNC
- 9p13.3 by Entrez Gene
- 9p13.3 by Ensembl
RECK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RECK Gene
Proteins for RECK Gene
-
Protein details for RECK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95980-RECK_HUMAN
- Recommended name:
- Reversion-inducing cysteine-rich protein with Kazal motifs
- Protein Accession:
- O95980
- B2RNS1
- Q5W0K6
- Q8WX37
Protein attributes for RECK Gene
- Size:
- 971 amino acids
- Molecular mass:
- 106457 Da
- Quaternary structure:
-
- Interacts (via knot repeats) with WNT7A (via disordered linker region); the interaction is direct (PubMed:30026314). Interacts (via knot repeats) with WNT7B (via disordered linker region); the interaction is direct (PubMed:30026314). Interacts with ADGRA2; the interaction is direct (PubMed:30026314). Interacts with MMP9 (PubMed:9789069).
Protein Expression for RECK Gene
Post-translational modifications for RECK Gene
- N-glycosylated.
-
Glycosylation at Asn39, Asn86, Asn200, Asn297, and Asn352
- NX_O95980 (NX_O95980-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RECK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ RECK Antibody
-
Custom Antibody ServicesOriGene Antibodies for RECK
- Novus Biologicals Antibodies for RECK
-
Abcam antibodies for RECK
- Invitrogen Antibodies for RECK (AFLGC-RECK)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RECK
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RECK
- Origene Custom Protein Services for RECK
- antibodies-online: Show 4 available RECK Proteins ranked by validation data
- Compare Top RECK Proteins
-
Quality Products:
-
Abcam proteins for RECK
Assay products for research
- antibodies-online: Show 10 available RECK Elisa Kits ranked by validation data
- Compare Top RECK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RECK Gene
Domains & Families for RECK Gene
Gene Families for RECK Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
Protein Domains for RECK Gene
- InterPro:
- Blocks:
-
- Protease inhibitor, Kazal-type
Suggested Antigen Peptide Sequences for RECK Gene
- GenScript: Design optimal peptide antigens:
-
- RECK protein (Q6P9E2_HUMAN)
- Suppressor of tumorigenicity 15 protein (RECK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95980UniProtKB/Swiss-Prot:
RECK_HUMAN :- The Kazal-like domains mediate the serine protease inhibitor activity.
- Belongs to the RECK family.
- Domain:
-
- The Kazal-like domains mediate the serine protease inhibitor activity.
- Family:
-
- Belongs to the RECK family.
Function for RECK Gene
Molecular function for RECK Gene
- UniProtKB/Swiss-Prot Function:
- Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).
Phenotypes From GWAS Catalog for RECK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004866 | endopeptidase inhibitor activity | IDA | 9789069 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21255571 |
| GO:0008191 | metalloendopeptidase inhibitor activity | TAS,IDA | 18194466 |
| GO:0017147 | Wnt-protein binding | IEA | -- |
Phenotypes for RECK Gene
- MGI mutant phenotypes for RECK:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for RECK:
-
- Increased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- no effect
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased hepcidin::fluc mRNA expression
- Increased viability
- Increased caspase activity
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased homologous recombination repair frequency
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RECK - Starting at $85 >
- * RECK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RECK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RECK
-
Santa Cruz Biotechnology (SCBT) CRISPR for RECK
miRNA for RECK Gene
- miRTarBase miRNAs that target RECK
-
- hsa-miR-373-3p (MIRT000606)
- hsa-miR-15b-5p (MIRT000607)
- hsa-miR-21-5p (MIRT000969)
- mmu-miR-21a-5p (MIRT002023)
- hsa-miR-222-3p (MIRT006728)
- hsa-miR-15a-5p (MIRT007090)
- hsa-miR-182-5p (MIRT007293)
- mmu-miR-340-5p (MIRT010497)
- mmu-miR-149-5p (MIRT014674)
- hsa-miR-335-5p (MIRT018129)
- hsa-miR-124-3p (MIRT022764)
- hsa-miR-103a-3p (MIRT027078)
- hsa-miR-16-5p (MIRT031373)
- hsa-miR-25-3p (MIRT053577)
- hsa-miR-374b-5p (MIRT054260)
- hsa-miR-221-3p (MIRT054649)
- hsa-miR-195-5p (MIRT107688)
- hsa-miR-424-5p (MIRT107689)
- hsa-miR-497-5p (MIRT107690)
- hsa-miR-562 (MIRT107692)
- hsa-miR-4524a-5p (MIRT107696)
- hsa-miR-4524b-5p (MIRT107698)
- hsa-miR-6838-5p (MIRT107699)
- hsa-miR-96-5p (MIRT438045)
- hsa-miR-92b-3p (MIRT438481)
- hsa-miR-7847-3p (MIRT454978)
- hsa-miR-1294 (MIRT454979)
- hsa-miR-6880-5p (MIRT454980)
- hsa-miR-6894-5p (MIRT454981)
- hsa-miR-7154-3p (MIRT454982)
- hsa-miR-765 (MIRT454983)
- hsa-miR-766-5p (MIRT454984)
- hsa-miR-5192 (MIRT454985)
- hsa-miR-4722-5p (MIRT454986)
- hsa-miR-6134 (MIRT454987)
- hsa-miR-7854-3p (MIRT454988)
- hsa-miR-4693-3p (MIRT454989)
- hsa-miR-4768-3p (MIRT454990)
- hsa-miR-3922-5p (MIRT454991)
- hsa-miR-940 (MIRT454992)
- hsa-miR-6893-5p (MIRT454993)
- hsa-miR-6808-5p (MIRT454994)
- hsa-miR-5586-3p (MIRT454995)
- hsa-miR-3714 (MIRT454996)
- hsa-miR-1271-5p (MIRT554826)
- hsa-miR-29b-2-5p (MIRT554827)
- hsa-miR-190a-3p (MIRT554828)
- hsa-miR-299-5p (MIRT554829)
- hsa-miR-410-3p (MIRT554830)
- hsa-miR-646 (MIRT554831)
- hsa-miR-618 (MIRT554832)
- hsa-miR-548x-3p (MIRT554833)
- hsa-miR-548j-3p (MIRT554834)
- hsa-miR-548aq-3p (MIRT554835)
- hsa-miR-548am-3p (MIRT554836)
- hsa-miR-548aj-3p (MIRT554837)
- hsa-miR-548ah-3p (MIRT554838)
- hsa-miR-548ae-3p (MIRT554839)
- hsa-miR-548z (MIRT554840)
- hsa-miR-548h-3p (MIRT554841)
- hsa-miR-548d-3p (MIRT554842)
- hsa-miR-548bb-3p (MIRT554843)
- hsa-miR-548ac (MIRT554844)
- hsa-miR-503-5p (MIRT554845)
- hsa-miR-135b-5p (MIRT731169)
- hsa-miR-15b-3p (MIRT731853)
- hsa-miR-409-3p (MIRT731975)
- hsa-miR-497-5p (MIRT733407)
- mmu-miR-497a-5p (MIRT733408)
- hsa-miR-590-5p (MIRT733551)
- hsa-miR-183-5p (MIRT734040)
- mmu-miR-21a-3p (MIRT735209)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RECK
- Browse OriGene Inhibitory RNA Products For RECK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RECK
Clone products for research
- Applied Biological Materials (abm): Clones for RECK - Starting at $45 >
- * RECK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RECK
- Addgene plasmids for RECK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RECK
Cell Lines for research
-
Horizon Cell Lines for RECK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RECK Gene
Localization for RECK Gene
Subcellular locations from UniProtKB/Swiss-Prot for RECK Gene
- Cell membrane. Lipid-anchor, GPI-anchor.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | TAS | 9789069 |
| GO:0031225 | anchored component of membrane | IEA | -- |
| GO:1990909 | Wnt signalosome | IEA | -- |
Pathways & Interactions for RECK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Angiogenesis (CST) | ||
| 3 | MicroRNAs in cancer | ||
| 4 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
| 5 | Post-translational modification- synthesis of GPI-anchored proteins | ||
Pathways by source for RECK Gene
3 Reactome pathways for RECK Gene
1 KEGG pathway for RECK Gene
1 Qiagen pathway for RECK Gene
- Inhibition of Matrix Metalloproteinases
1 Cell Signaling Technology pathway for RECK Gene
Interacting Proteins for RECK Gene
Selected Interacting proteins:
O95980-RECK_HUMAN
ENSP00000367202
for RECK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RECK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001955 | blood vessel maturation | IBA | 21873635 |
| GO:0002040 | sprouting angiogenesis | IBA | 21873635 |
| GO:0007566 | embryo implantation | IEA | -- |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for RECK Gene
Transcripts for RECK Gene
mRNA/cDNA for RECK Gene
- 5 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377966 4412 nts (view in UCSC)
- ENST00000475774 1128 nts (view in UCSC)
- ENST00000479053 1717 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RECK - Starting at $85 >
- * RECK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RECK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RECK
-
Santa Cruz Biotechnology (SCBT) CRISPR for RECK
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RECK
- Browse OriGene Inhibitory RNA Products For RECK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RECK
Clone products for research
- Applied Biological Materials (abm): Clones for RECK - Starting at $45 >
- * RECK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RECK
- Addgene plasmids for RECK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RECK
Relevant External Links for RECK Gene
- GeneLoc Exon Structure for
- RECK
Expression for RECK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Detroit 551
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
- Heart (Cardiovascular System)
- Fibroblasts
-
Ovary (Reproductive System)
This gene is overexpressed in Plasma (11.0), Skin (9.7), Cerebral cortex (8.6), and Serum (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RECK Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RECK
SOURCE GeneReport for Unigene cluster for RECK Gene:
Hs.388918mRNA Expression by UniProt/SwissProt for RECK Gene:
O95980-RECK_HUMAN
Tissue specificity:
Expressed in various tissues and untransformed cells (PubMed:9789069). It is undetectable in tumor-derived cell lines and oncogenically transformed cells (PubMed:9789069).
Evidence on tissue expression from TISSUES for RECK Gene
- Lung(4.4)
- Pancreas(2.7)
- Intestine(2.7)
- Heart(2.4)
- Nervous system(2.3)
- Kidney(2.1)
- Skin(2)
- Lymph node(2)
- Blood(2)
- Muscle(2)
Primer products for research
-
OriGene qPCR primer pairs for RECK
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RECK Gene
Orthologs for RECK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RECK 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RECK 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RECK 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RECK 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RECK 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Reck 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Reck 29 |
|
||
| Chicken (Gallus gallus) |
Aves | RECK 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RECK 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | reck 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | RECK 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Reck 29 30 |
|
OneToOne | |
| CG5392 31 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010646 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for RECK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RECK Gene
- ENSEMBL:
- Gene Tree for RECK (if available)
- TreeFam:
- Gene Tree for RECK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RECK: view image
- Alliance of Genome Resources:
- Additional Orthologs for RECK
Paralogs for RECK Gene
No data available for Paralogs for RECK Gene
Variants for RECK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RECK Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140438492 | Benign: not provided | 36,102,091(+) |
A/C NM_021111.3(RECK):c.1299-3A>C |
INTRON | |
| rs556592531 | Likely Benign: not provided | 36,102,099(+) |
A/G NM_021111.3(RECK):c.1304A>G (p.Asp435Gly) |
MISSENSE | |
| rs56680169 | Benign: not provided | 36,122,958(+) |
C/T NM_021111.3(RECK):c.2829C>T (p.Ala943=) |
SYNONYMOUS | |
| rs71521299 | Benign: not provided | 36,058,819(+) |
T/G NM_021111.3(RECK):c.160-8T>G |
INTRON | |
| rs16932912 | -- |
p.Val275Ile |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.99;
80.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RECK Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RECK Gene
Disorders for RECK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cancer |
|
|
| middle ear squamous cell carcinoma |
|
|
| middle ear carcinoma |
|
|
| lactose intolerance |
|
|
| ocular albinism |
|
|
Search RECK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RECK
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RECK Gene
Publications for RECK Gene
- Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. (PMID: 9789069) Takahashi C … Noda M (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22
- Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. (PMID: 17033924) Lei H … Försti A (Breast cancer research and treatment 2007) 3 22 40
- RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage. (PMID: 20395433) Kimura T … Okada Y (The American journal of pathology 2010) 3 22
- [Clinicopathological significance of expressions of RECK and MMP-2 in esophageal squamous carcinoma]. (PMID: 20510080) Qi M … Li Y (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2010) 3 22
- Role of RECK methylation in gastric cancer and its clinical significance. (PMID: 20143471) Du YY … Yang Z (World journal of gastroenterology 2010) 3 22
ExternalLinks
Products for RECK Gene
- View all 8 R&D Systems RECK (RECK) Products
- View all 2 R&D Systems RECK (RECK) Proteins and Enzymes
- View all 3 R&D Systems RECK (RECK) Primary Antibodies
- View all 2 R&D Systems RECK (RECK) Proteome Profiler Antibody Arrays
- View all R&D Systems RECK (RECK) cDNA Clones
- Learn more about R&D Systems custom RECK antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for RECK
- Browse OriGene ELISA Kits
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RECK
- Origene Custom Protein Services for RECK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RECK
- Browse OriGene Inhibitory RNA Products For RECK
- OriGene qPCR primer pairs for RECK
- OriGene CRISPR knockouts for RECK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RECK
- Sino Biological Human cDNA Clone for RECK
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for RECK
- Novus Biologicals proteins and lysates for RECK
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- Invitrogen Antibodies for RECK (AFLGC-RECK)
- VectorBuilder Custom and pre-made DNA vectors for RECK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RECK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RECK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RECK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RECK
- Addgene plasmids for RECK
- antibodies-online: Show 18 available RECK Antibodies ranked by validation data
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- antibodies-online: Show 10 available RECK Elisa Kits ranked by validation data
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- antibodies-online: Show 4 available RECK Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for RECK
- Search Santa Cruz Biotechnology (SCBT) for RECK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RECK
- Horizon Cell Lines for RECK
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RECK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RECK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RECK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RECK
Sources for RECK Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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