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Aliases for REC114 Gene

Aliases for REC114 Gene

  • REC114 Meiotic Recombination Protein 2 3 5
  • C15orf60 3 4
  • Meiotic Recombination Protein REC114-Like 3
  • Meiotic Recombination Protein REC114 3
  • Chromosome 15 Open Reading Frame 60 2
  • CT147 3

External Ids for REC114 Gene

Previous HGNC Symbols for REC114 Gene

  • C15orf60

Summaries for REC114 Gene

Entrez Gene Summary for REC114 Gene

  • The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. [provided by RefSeq, Feb 2017]

GeneCards Summary for REC114 Gene

REC114 (REC114 Meiotic Recombination Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for REC114 Gene

  • Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Additional gene information for REC114 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for REC114 Gene

Genomics for REC114 Gene

GeneHancer (GH) Regulatory Elements for REC114 Gene

Promoters and enhancers for REC114 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I073374 Enhancer 0.9 VISTA 550.8 +0.2 182 4.3 PKNOX1 ZBTB6 ZNF133 ZNF76 ZIC2 GATA3 GLIS2 RCOR1 ZNF444 CHD2 REC114 ENSG00000261384 ADPGK NEO1 GC15P073451
GH15I073443 Promoter 0.7 EPDnew 550.2 +66.9 66936 0.1 PKNOX1 GABPB1 REC114 GC15P073451
GH15I073318 Enhancer 0.8 FANTOM5 ENCODE 16.8 -57.3 -57303 0.4 MXI1 RFX1 MAX SIN3A EBF1 BMI1 POLR2A MYNN GLIS1 REC114 NEO1 HCN4 PIR60762 PIR39750
GH15I073386 Enhancer 0.9 Ensembl ENCODE 0.4 +11.7 11669 1.8 PKNOX1 JUN MAX RFX5 ZEB1 CTBP1 GATA3 RCOR1 FOSL2 FOS REC114 GC15P073451
GH15I073389 Enhancer 0.5 ENCODE 0.4 +13.6 13588 1.1 ELF3 HNF4A ZNF644 MAFK GABPA NFE2L2 HCN4 REC114 GC15P073451
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around REC114 on UCSC Golden Path with GeneCards custom track

Genomic Locations for REC114 Gene

Genomic Locations for REC114 Gene
183,806 bases
Plus strand

Genomic View for REC114 Gene

Genes around REC114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
REC114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for REC114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for REC114 Gene

Proteins for REC114 Gene

  • Protein details for REC114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiotic recombination protein REC114
    Protein Accession:

    Protein attributes for REC114 Gene

    266 amino acids
    Molecular mass:
    29155 Da
    Quaternary structure:
    • Interacts with MEI4. Interacts with IHO1/CCDC36. Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4.
    • Sequence=AAH55412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for REC114 Gene

Post-translational modifications for REC114 Gene

No Post-translational modifications

Other Protein References for REC114 Gene

No data available for DME Specific Peptides for REC114 Gene

Domains & Families for REC114 Gene

Gene Families for REC114 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for REC114 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the REC114 family.
  • Belongs to the REC114 family.
genes like me logo Genes that share domains with REC114: view

No data available for Suggested Antigen Peptide Sequences for REC114 Gene

Function for REC114 Gene

Molecular function for REC114 Gene

UniProtKB/Swiss-Prot Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.

Phenotypes From GWAS Catalog for REC114 Gene

genes like me logo Genes that share phenotypes with REC114: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for REC114 Gene

Localization for REC114 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for REC114 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for REC114 Gene

Pathways & Interactions for REC114 Gene

SuperPathways for REC114 Gene

No Data Available

Interacting Proteins for REC114 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q7Z4M0-RE114_HUMAN ENSP00000328423 for REC114 Gene via IID STRING

Gene Ontology (GO) - Biological Process for REC114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with REC114: view

No data available for Pathways by source and SIGNOR curated interactions for REC114 Gene

Drugs & Compounds for REC114 Gene

No Compound Related Data Available

Transcripts for REC114 Gene

mRNA/cDNA for REC114 Gene

(3) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for REC114 Gene

No ASD Table

Relevant External Links for REC114 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for REC114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for REC114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for REC114 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for REC114 Gene

Protein tissue co-expression partners for REC114 Gene

NURSA nuclear receptor signaling pathways regulating expression of REC114 Gene:

genes like me logo Genes that share expression patterns with REC114: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for REC114 Gene

Orthologs for REC114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for REC114 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C15H15orf60 33
  • 99.62 (n)
C15orf60 34
  • 97 (a)
(Bos Taurus)
Mammalia C10H15orf60 33
  • 81.12 (n)
(Canis familiaris)
Mammalia C30H15orf60 33
  • 79.45 (n)
C15orf60 34
  • 73 (a)
(Rattus norvegicus)
Mammalia RGD1311874 33
  • 77.86 (n)
(Mus musculus)
Mammalia 2410076I21Rik 34 33
  • 76.45 (n)
Rec114 16
(Monodelphis domestica)
Mammalia C15orf60 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia C15orf60 34
  • 55 (a)
(Gallus gallus)
Aves C10H15ORF60 33
  • 65.17 (n)
C15orf60 34
  • 45 (a)
(Anolis carolinensis)
Reptilia C15orf60 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734605 33
  • 55.09 (n)
(Danio rerio)
Actinopterygii C18H15orf60 (2 of 2) 34
  • 41 (a)
C18H15orf60 (1 of 2) 34
  • 38 (a)
Species where no ortholog for REC114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for REC114 Gene

Gene Tree for REC114 (if available)
Gene Tree for REC114 (if available)

Paralogs for REC114 Gene

No data available for Paralogs for REC114 Gene

Variants for REC114 Gene

Sequence variations from dbSNP and Humsavar for REC114 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000068084 -- 73,443,584(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000084866 -- 73,516,678(+) A/G intron_variant
rs1000121537 -- 73,443,875(+) AGAGA/AGA genic_upstream_transcript_variant, intron_variant
rs1000143976 -- 73,502,169(+) A/G intron_variant
rs1000150700 -- 73,457,173(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for REC114 Gene

Variant ID Type Subtype PubMed ID
nsv525433 CNV loss 19592680
nsv1139632 CNV duplication 24896259
nsv1121512 CNV deletion 24896259
nsv1051734 CNV loss 25217958
esv3636889 CNV loss 21293372
esv3636888 CNV loss 21293372
esv2749872 CNV deletion 23290073
esv2673071 CNV deletion 23128226
esv2662664 CNV deletion 23128226

Variation tolerance for REC114 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for REC114 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for REC114 Gene

Disorders for REC114 Gene

Additional Disease Information for REC114

No disorders were found for REC114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for REC114 Gene

Publications for REC114 Gene

  1. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. (PMID: 20551173) Kumar R … de Massy B (Genes & development 2010) 2 3 58
  2. Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications. (PMID: 28100913) Ueta M … Tokunaga K (Journal of human genetics 2017) 3 58
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G … Rudan I (PLoS genetics 2013) 3 58
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for REC114 Gene

Sources for REC114 Gene

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