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Aliases for RDH14 Gene

Aliases for RDH14 Gene

  • Retinol Dehydrogenase 14 2 3 3 5
  • Short Chain Dehydrogenase/Reductase Family 7C Member 4 3 4
  • Retinol Dehydrogenase 14 (All-Trans/9-Cis/11-Cis) 2 3
  • Retinol Dehydrogenase 14 (All-Trans And 9-Cis) 2 3
  • Alcohol Dehydrogenase PAN2 3 4
  • SDR7C4 3 4
  • PAN2 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 4 2
  • Pancreas Protein 2 3
  • EC 1.1.1.- 4

External Ids for RDH14 Gene

Previous GeneCards Identifiers for RDH14 Gene

  • GC02M018670
  • GC02M018703
  • GC02M018720
  • GC02M018658
  • GC02M018659
  • GC02M018600
  • GC02M018601
  • GC02M018735

Summaries for RDH14 Gene

GeneCards Summary for RDH14 Gene

RDH14 (Retinol Dehydrogenase 14) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Purine metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH13.

UniProtKB/Swiss-Prot for RDH14 Gene

  • Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.

Gene Wiki entry for RDH14 Gene

Additional gene information for RDH14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH14 Gene

Genomics for RDH14 Gene

GeneHancer (GH) Regulatory Elements for RDH14 Gene

Promoters and enhancers for RDH14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J018559 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 435 2.3 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 RDH14 ENSG00000260331 NT5C1B-RDH14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RDH14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RDH14 gene promoter:
  • Roaz
  • c-Myb
  • FOXD3
  • E47
  • IRF-7A
  • CP2
  • NF-1
  • HSF1short
  • HSF1 (long)
  • POU2F1

Genomic Locations for RDH14 Gene

Genomic Locations for RDH14 Gene
chr2:18,554,723-18,560,693
(GRCh38/hg38)
Size:
5,971 bases
Orientation:
Minus strand
chr2:18,735,989-18,741,959
(GRCh37/hg19)
Size:
5,971 bases
Orientation:
Minus strand

Genomic View for RDH14 Gene

Genes around RDH14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RDH14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RDH14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH14 Gene

Proteins for RDH14 Gene

  • Protein details for RDH14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH5-RDH14_HUMAN
    Recommended name:
    Retinol dehydrogenase 14
    Protein Accession:
    Q9HBH5

    Protein attributes for RDH14 Gene

    Size:
    336 amino acids
    Molecular mass:
    36865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RDH14 Gene

Post-translational modifications for RDH14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RDH14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RDH14 Gene

Domains & Families for RDH14 Gene

Gene Families for RDH14 Gene

Suggested Antigen Peptide Sequences for RDH14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBH5

UniProtKB/Swiss-Prot:

RDH14_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with RDH14: view

Function for RDH14 Gene

Molecular function for RDH14 Gene

UniProtKB/Swiss-Prot Function:
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.

Enzyme Numbers (IUBMB) for RDH14 Gene

Gene Ontology (GO) - Molecular Function for RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008106 alcohol dehydrogenase (NADP+) activity IEA --
GO:0016491 oxidoreductase activity IBA --
GO:0052650 NADP-retinol dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with RDH14: view
genes like me logo Genes that share phenotypes with RDH14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RDH14

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RDH14 Gene

Localization for RDH14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RDH14 gene
Compartment Confidence
nucleus 5
lysosome 5
endoplasmic reticulum 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with RDH14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RDH14 Gene

Pathways & Interactions for RDH14 Gene

genes like me logo Genes that share pathways with RDH14: view

Pathways by source for RDH14 Gene

1 GeneGo (Thomson Reuters) pathway for RDH14 Gene
1 Qiagen pathway for RDH14 Gene

Gene Ontology (GO) - Biological Process for RDH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0042572 retinol metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RDH14: view

No data available for SIGNOR curated interactions for RDH14 Gene

Drugs & Compounds for RDH14 Gene

(1) Drugs for RDH14 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target 529

(1) Additional Compounds for RDH14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with RDH14: view

Transcripts for RDH14 Gene

mRNA/cDNA for RDH14 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(136) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RDH14 Gene

Retinol dehydrogenase 14 (all-trans/9-cis/11-cis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RDH14 Gene

No ASD Table

Relevant External Links for RDH14 Gene

GeneLoc Exon Structure for
RDH14
ECgene alternative splicing isoforms for
RDH14

Expression for RDH14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RDH14 Gene

Protein differential expression in normal tissues from HIPED for RDH14 Gene

This gene is overexpressed in Nasal epithelium (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RDH14 Gene



Protein tissue co-expression partners for RDH14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RDH14 Gene:

RDH14

SOURCE GeneReport for Unigene cluster for RDH14 Gene:

Hs.120319

mRNA Expression by UniProt/SwissProt for RDH14 Gene:

Q9HBH5-RDH14_HUMAN
Tissue specificity: Expressed in brain, kidney, pancreas and placenta.

Evidence on tissue expression from TISSUES for RDH14 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with RDH14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RDH14 Gene

Orthologs for RDH14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RDH14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RDH14 33
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia RDH14 34 33
  • 91.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RDH14 34 33
  • 86.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rdh14 16 34 33
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Rdh14 33
  • 85.13 (n)
oppossum
(Monodelphis domestica)
Mammalia RDH14 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RDH14 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves RDH14 34 33
  • 72.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RDH14 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rdh14 33
  • 73.62 (n)
zebrafish
(Danio rerio)
Actinopterygii rdh14a 34
  • 72 (a)
OneToMany
rdh14b 34
  • 67 (a)
OneToMany
Dr.16840 33
fruit fly
(Drosophila melanogaster)
Insecta CG3842 33
  • 50.89 (n)
CG7675 34
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dhs-24 34
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 34
  • 25 (a)
OneToMany
PBR1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09278 33
  • 47.08 (n)
Species where no ortholog for RDH14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RDH14 Gene

ENSEMBL:
Gene Tree for RDH14 (if available)
TreeFam:
Gene Tree for RDH14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RDH14: view image

Paralogs for RDH14 Gene

Paralogs for RDH14 Gene

(7) SIMAP similar genes for RDH14 Gene using alignment to 2 proteins:

  • RDH14_HUMAN
  • Q53RX3_HUMAN
genes like me logo Genes that share paralogs with RDH14: view

Variants for RDH14 Gene

Sequence variations from dbSNP and Humsavar for RDH14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000108601 -- 18,562,599(-) G/A upstream_transcript_variant
rs1000390528 -- 18,556,620(-) G/C intron_variant
rs1001092360 -- 18,560,291(-) G/A coding_sequence_variant, synonymous_variant
rs1001519112 -- 18,556,537(-) A/G intron_variant
rs1001896834 -- 18,557,069(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RDH14 Gene

Variant ID Type Subtype PubMed ID
esv2751837 CNV gain 17911159
esv3589966 CNV loss 21293372
nsv2624 CNV insertion 18451855
nsv581114 CNV gain 21841781

Variation tolerance for RDH14 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RDH14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RDH14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDH14 Gene

Disorders for RDH14 Gene

Additional Disease Information for RDH14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RDH14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RDH14 Gene

Publications for RDH14 Gene

  1. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F … Palczewski K (The Journal of biological chemistry 2002) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for RDH14 Gene

Sources for RDH14 Gene

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