Aliases for RDH13 Gene
External Ids for RDH13 Gene
Previous GeneCards Identifiers for RDH13 Gene
This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
GeneCards Summary for RDH13 Gene
RDH13 (Retinol Dehydrogenase 13) is a Protein Coding gene. Diseases associated with RDH13 include Fundus Albipunctatus and Optic Nerve Hypoplasia, Bilateral. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH14.
UniProtKB/Swiss-Prot Summary for RDH13 Gene
Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331).