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Aliases for RDH13 Gene

Aliases for RDH13 Gene

  • Retinol Dehydrogenase 13 2 3 3 5
  • Short Chain Dehydrogenase/Reductase Family 7C Member 3 3 4
  • Retinol Dehydrogenase 13 (All-Trans And 9-Cis) 2 3
  • Retinol Dehydrogenase 13 (All-Trans/9-Cis) 2 3
  • SDR7C3 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 3 2
  • EC 1.1.1.- 4

External Ids for RDH13 Gene

Previous GeneCards Identifiers for RDH13 Gene

  • GC19M055979
  • GC19M060231
  • GC19M060247
  • GC19M055556
  • GC19M051879

Summaries for RDH13 Gene

Entrez Gene Summary for RDH13 Gene

  • This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for RDH13 Gene

RDH13 (Retinol Dehydrogenase 13) is a Protein Coding gene. Among its related pathways are Signaling by Retinoic Acid and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH11.

UniProtKB/Swiss-Prot for RDH13 Gene

  • Does not exhibit retinol dehydrogenase (RDH) activity in vitro.

Additional gene information for RDH13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RDH13 Gene

Genomics for RDH13 Gene

GeneHancer (GH) Regulatory Elements for RDH13 Gene

Promoters and enhancers for RDH13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055062 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 675.5 +8.4 8412 1.7 HDGF PKNOX1 ATF1 ARNT SIN3A DMAP1 BRCA1 ZNF48 GTF3C2 GLIS2 RDH13 CNOT3 ENSG00000235681 LENG8 LENG8-AS1 U2AF2 ZNF581 ENSG00000267523 PRPF31 ENSG00000267265
GH19J055068 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 769 3.1 PKNOX1 CLOCK ATF1 SIN3A BRCA1 GLIS2 FOS ATF7 DEK REST EPS8L1 RDH13 ENSG00000267149
GH19J055111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.2 -44.1 -44092 8 HDGF ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 POLR2B PPP1R12C GC19M055111 EPS8L1 RDH13 U2AF2 LENG8-AS1 LENG8 ENSG00000235681 CNOT3 ENSG00000267523
GH19J055079 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 17.8 -9.6 -9577 2.6 HDGF PKNOX1 CLOCK ATF1 ARNT DMAP1 ZNF48 POLR2B GLIS2 KLF7 EPS8L1 RDH13 GC19M055111
GH19J055005 Promoter/Enhancer 1.5 Ensembl ENCODE 24.5 +64.8 64811 2.1 PKNOX1 SMAD1 ATF1 ARNT ETS1 POLR2B ZNF766 E2F8 ZNF416 ATF7 ENSG00000267265 PRPF31 RDH13 NLRP2 U2AF2 LENG8 CNOT3 ENSG00000243494 NLRP7 GP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RDH13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RDH13 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • NF-1
  • Olf-1
  • Zic1

Genomic Locations for RDH13 Gene

Genomic Locations for RDH13 Gene
32,184 bases
Minus strand
32,184 bases
Minus strand

Genomic View for RDH13 Gene

Genes around RDH13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RDH13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RDH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RDH13 Gene

Proteins for RDH13 Gene

  • Protein details for RDH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol dehydrogenase 13
    Protein Accession:
    Secondary Accessions:
    • Q6UX79
    • Q96G88

    Protein attributes for RDH13 Gene

    331 amino acids
    Molecular mass:
    35932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RDH13 Gene


neXtProt entry for RDH13 Gene

Post-translational modifications for RDH13 Gene

  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RDH13
  • Boster Bio Antibodies for RDH13
  • Santa Cruz Biotechnology (SCBT) Antibodies for RDH13

No data available for DME Specific Peptides for RDH13 Gene

Domains & Families for RDH13 Gene

Gene Families for RDH13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for RDH13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with RDH13: view

Function for RDH13 Gene

Molecular function for RDH13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit retinol dehydrogenase (RDH) activity in vitro.

Enzyme Numbers (IUBMB) for RDH13 Gene

Phenotypes From GWAS Catalog for RDH13 Gene

Gene Ontology (GO) - Molecular Function for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0052650 NADP-retinol dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with RDH13: view
genes like me logo Genes that share phenotypes with RDH13: view

Animal Models for RDH13 Gene

MGI Knock Outs for RDH13:

Animal Model Products

  • Taconic Biosciences Mouse Models for RDH13

miRNA for RDH13 Gene

miRTarBase miRNAs that target RDH13

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RDH13 Gene

Localization for RDH13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RDH13 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with RDH13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RDH13 Gene

Pathways & Interactions for RDH13 Gene

genes like me logo Genes that share pathways with RDH13: view

Pathways by source for RDH13 Gene

1 Qiagen pathway for RDH13 Gene

Gene Ontology (GO) - Biological Process for RDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009644 response to high light intensity IEA --
GO:0010842 retina layer formation IEA --
GO:0042462 eye photoreceptor cell development IEA --
GO:0042572 retinol metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RDH13: view

No data available for SIGNOR curated interactions for RDH13 Gene

Drugs & Compounds for RDH13 Gene

(3) Drugs for RDH13 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target 529
1-Butanol Experimental Pharma 0
Pyruvaldehyde Experimental Pharma 0

(6) Additional Compounds for RDH13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 13-keto-9Z,11E-Octadecadienoic acid
  • 13-KetoODE
  • 13-KODE
  • 13-oxo-ODE
  • 13-keto-9Z,11E-Octadecadienoate
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-Tetrahydroxy-5-beta-cholestanoyl-CoA
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-Tetrahydroxy-5-beta-cholestanoyl-coenzyme A
  • 3a,7a,12a,24-Tetrahydroxy-5b-cholestanoyl-coenzyme A
  • 3a,7a,12a,24Z-Tetrahydroxy-5b-cholestanoyl-CoA
  • 3a,7a,12a,24Z-Tetrahydroxy-5b-cholestanoyl-coenzyme A
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-Tetrahydroxy-5-beta-cholestan-26-oyl-CoA
  • (24R,25R)-3-alpha,7-alpha,12-alpha,24-Tetrahydroxy-5-beta-cholestan-26-oyl-coenzyme A
  • 24-oxo-25(R)-Trihydroxycoprostanoyl-CoA
  • 24-oxo-25(R)-Trihydroxycoprostanoyl-coenzyme A
  • 25(R)-24-oxo-3alpha,7alpha,12alpha-Trihydroxycoprostanoyl-CoA
  • 3,7,12-Trihydroxy-5beta-cholestanoyl-CoA
  • 3,7,12-Trihydroxycholestan-26-oyl-CoA
  • 3,7,12-Trihydroxycoprostanoyl-CoA
  • 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-coenzyme A
  • 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA
  • 1-Butanal
  • Aldehyde butyrique
  • Aldeide butirrica
  • Butal
  • Butaldehyde
genes like me logo Genes that share compounds with RDH13: view

Transcripts for RDH13 Gene

Unigene Clusters for RDH13 Gene

Retinol dehydrogenase 13 (all-trans/9-cis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RDH13 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: -
SP8: -

Relevant External Links for RDH13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RDH13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RDH13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RDH13 Gene

This gene is overexpressed in Nasal epithelium (10.4), Bone (7.7), and Placenta (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RDH13 Gene

Protein tissue co-expression partners for RDH13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RDH13 Gene:


SOURCE GeneReport for Unigene cluster for RDH13 Gene:


mRNA Expression by UniProt/SwissProt for RDH13 Gene:

Tissue specificity: Expressed mostly in eye, pancreas, placenta and lung. In the retina, detected in the inner segment of the photoreceptor cells. Weak signals were observed in a small population of inner nuclear neurons and the inner plexiform layer.

Evidence on tissue expression from TISSUES for RDH13 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with RDH13: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RDH13 Gene

Orthologs for RDH13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RDH13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RDH13 34 33
  • 99.4 (n)
(Canis familiaris)
Mammalia RDH13 34 33
  • 87.31 (n)
(Bos Taurus)
Mammalia RDH13 34 33
  • 87.01 (n)
(Rattus norvegicus)
Mammalia Rdh13 33
  • 84.27 (n)
(Mus musculus)
Mammalia Rdh13 16 34 33
  • 84.01 (n)
(Ornithorhynchus anatinus)
Mammalia RDH13 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rdh13 33
  • 66.35 (n)
(Danio rerio)
Actinopterygii si:dkey-23o4.6 33
  • 57.1 (n)
rdh12l 34
  • 52 (a)
sbcb464 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005980 33
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30491 34 33
  • 55.8 (n)
CG2064 34
  • 52 (a)
CG2070 34
  • 51 (a)
CG2065 34
  • 51 (a)
CG30495 34
  • 45 (a)
CG3842 34
  • 37 (a)
Species where no ortholog for RDH13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RDH13 Gene

Gene Tree for RDH13 (if available)
Gene Tree for RDH13 (if available)
Evolutionary constrained regions (ECRs) for RDH13: view image

Paralogs for RDH13 Gene

Paralogs for RDH13 Gene

(9) SIMAP similar genes for RDH13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RDH13: view

Variants for RDH13 Gene

Sequence variations from dbSNP and Humsavar for RDH13 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs571440646 uncertain-significance, not specified 55,045,175(-) C/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000059137 -- 55,044,071(-) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000087297 -- 55,069,603(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000118475 -- 55,069,854(-) G/A upstream_transcript_variant
rs1000211189 -- 55,053,181(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RDH13 Gene

Variant ID Type Subtype PubMed ID
dgv1819n106 OTHER inversion 24896259
esv2667609 CNV deletion 23128226
esv2671441 CNV deletion 23128226
esv2672890 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2718944 CNV deletion 23290073
esv2758772 CNV gain 17122850
esv2762052 CNV gain 21179565
esv2763211 CNV gain 21179565
esv34356 CNV gain 17911159
esv3644829 CNV gain 21293372
esv3644830 CNV loss 21293372
esv3644831 CNV gain 21293372
esv3644834 CNV loss 21293372
esv3644835 CNV loss 21293372
esv9070 CNV loss 19470904
nsv1063883 CNV gain 25217958
nsv1079034 OTHER inversion 25765185
nsv1109218 CNV deletion 24896259
nsv1123280 CNV deletion 24896259
nsv1134812 CNV deletion 24896259
nsv1150276 OTHER inversion 26484159
nsv580341 CNV loss 21841781
nsv580342 CNV loss 21841781
nsv817874 CNV loss 17921354
nsv833880 CNV loss 17160897
nsv9770 CNV loss 18304495

Variation tolerance for RDH13 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RDH13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RDH13 Gene

Disorders for RDH13 Gene

Additional Disease Information for RDH13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RDH13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RDH13 Gene

Publications for RDH13 Gene

  1. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. (PMID: 12226107) Haeseleer F … Palczewski K (The Journal of biological chemistry 2002) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
  4. Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. (PMID: 18039331) Belyaeva OV … Kedishvili NY (The FEBS journal 2008) 3 22 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for RDH13 Gene

Sources for RDH13 Gene

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